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The map label for this gene is PcaR [H]

Identifier: 218548989

GI number: 218548989

Start: 1683462

End: 1684268

Strand: Direct

Name: PcaR [H]

Synonym: EFER_1637

Alternate gene names: 218548989

Gene position: 1683462-1684268 (Clockwise)

Preceding gene: 218548982

Following gene: 218548991

Centisome position: 36.69

GC content: 49.32

Gene sequence:

>807_bases
GTGGAAAAACATCCTGATGATCGGCTGAACAGTGATGCCGATCCTTTTAAAGGCGATCCAAATTTTATGGCCTCGCTGGC
GCGTGGACTGGACGTTATTCAGGCATTTACCCCGCAGCGACGGATGATGTCTATTTCACAAATTAGCCAGAAAACAGGCA
TCCCAAGAGCAGCTGTCAGGCGCTGCCTTTATACACTGGGGAAATTGGGATTTGTTTATGCGCAGGATGGTAAAAATTTC
GAACTACGTCCGCGAATTCTGGCACTCGGTCATGCTTATCTTGCTTCAACACCACTGGCAAGAGCAGCACAACCGGTCCT
TAAACACTTAAGCGAAATGCTTAATGAATCCTGCTCTATTGCCACACTGGATGGTGACGATATTTTGTATATTGCCAGAG
CGTCCAGTTCACGCATAATGACCATCGACCTTGATATTGGCAGTCGTTTACCCGCATGGGCGACCTCGATGGGCCGCGTA
TTACTAAGCCATTTGCCCGAAGAAAATCTCAATGACTTACTGGGCAGAGTGACGATGATTCGCTACACCTCACAGACGGT
GGATTCCGTTTCAGCGCTACGTGAAGAGCTGAAAAAAGTACAACAACAAGGTTACGCCCTGAACGATCAGGAACTGGAGA
TGGGCTTGCGATCTATTGCGGTGCCATTAAGCAATACCCGAGGGCAAGTGCTGGCAGCATTGAACGTTGGCGTACATGCC
GGACAAGTCTCTGCTGATGAATTATTAAGCCGGGTACTGCCGGAGCTACAAAAAGCGGCGCAGGAACTCTCGCTCCTGCT
GGATTAG

Upstream 100 bases:

>100_bases
AATGCAATCAAGGGCGATAATCGAAATATGGTGCGATTATCGAACATCAGATATATTTGTTAGCAGAATGTGATCTAAGG
CGAACAGTGAGGAAAAAACA

Downstream 100 bases:

>100_bases
TTACCGACTGCGTTTGGCGTGGCGCTCCCAGTTTTCCTGTTTTGCCTGGGCAGTTTTACGCAATGCAACATAACATGCCC
CGCTGCCACCGTGATGTGGC

Product: Pca regulon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MEKHPDDRLNSDADPFKGDPNFMASLARGLDVIQAFTPQRRMMSISQISQKTGIPRAAVRRCLYTLGKLGFVYAQDGKNF
ELRPRILALGHAYLASTPLARAAQPVLKHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHLPEENLNDLLGRVTMIRYTSQTVDSVSALREELKKVQQQGYALNDQELEMGLRSIAVPLSNTRGQVLAALNVGVHA
GQVSADELLSRVLPELQKAAQELSLLLD

Sequences:

>Translated_268_residues
MEKHPDDRLNSDADPFKGDPNFMASLARGLDVIQAFTPQRRMMSISQISQKTGIPRAAVRRCLYTLGKLGFVYAQDGKNF
ELRPRILALGHAYLASTPLARAAQPVLKHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHLPEENLNDLLGRVTMIRYTSQTVDSVSALREELKKVQQQGYALNDQELEMGLRSIAVPLSNTRGQVLAALNVGVHA
GQVSADELLSRVLPELQKAAQELSLLLD
>Mature_268_residues
MEKHPDDRLNSDADPFKGDPNFMASLARGLDVIQAFTPQRRMMSISQISQKTGIPRAAVRRCLYTLGKLGFVYAQDGKNF
ELRPRILALGHAYLASTPLARAAQPVLKHLSEMLNESCSIATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRV
LLSHLPEENLNDLLGRVTMIRYTSQTVDSVSALREELKKVQQQGYALNDQELEMGLRSIAVPLSNTRGQVLAALNVGVHA
GQVSADELLSRVLPELQKAAQELSLLLD

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=257, Percent_Identity=31.1284046692607, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786468, Length=245, Percent_Identity=30.6122448979592, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI87082359, Length=247, Percent_Identity=27.9352226720648, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=24.8908296943231, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789999, Length=256, Percent_Identity=22.65625, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788581, Length=213, Percent_Identity=24.8826291079812, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693096, Length=234, Percent_Identity=26.4957264957265, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29450; Mature: 29450

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKHPDDRLNSDADPFKGDPNFMASLARGLDVIQAFTPQRRMMSISQISQKTGIPRAAVR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
RCLYTLGKLGFVYAQDGKNFELRPRILALGHAYLASTPLARAAQPVLKHLSEMLNESCSI
HHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCE
ATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRVLLSHLPEENLNDLLGRVTMI
EEECCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RYTSQTVDSVSALREELKKVQQQGYALNDQELEMGLRSIAVPLSNTRGQVLAALNVGVHA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
GQVSADELLSRVLPELQKAAQELSLLLD
CCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKHPDDRLNSDADPFKGDPNFMASLARGLDVIQAFTPQRRMMSISQISQKTGIPRAAVR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
RCLYTLGKLGFVYAQDGKNFELRPRILALGHAYLASTPLARAAQPVLKHLSEMLNESCSI
HHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCE
ATLDGDDILYIARASSSRIMTIDLDIGSRLPAWATSMGRVLLSHLPEENLNDLLGRVTMI
EEECCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RYTSQTVDSVSALREELKKVQQQGYALNDQELEMGLRSIAVPLSNTRGQVLAALNVGVHA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
GQVSADELLSRVLPELQKAAQELSLLLD
CCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]