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The map label for this gene is yddV [H]

Identifier: 218548932

GI number: 218548932

Start: 1618450

End: 1619841

Strand: Direct

Name: yddV [H]

Synonym: EFER_1579

Alternate gene names: 218548932

Gene position: 1618450-1619841 (Clockwise)

Preceding gene: 218548931

Following gene: 218548933

Centisome position: 35.27

GC content: 43.32

Gene sequence:

>1392_bases
GTGGGCATTATGGAGATGTACTTTAAAAGAATGAAAGATGAGTGGGTCGCGTTGGTTGAAAGAACTGACCCGGAAATCCG
AATAAAAGCATCGGAAATTGCCACCGCTCACGCGCTGACCTTGAGTCATGAATTTTACCGTATCGTTCGGGCAGATCCCC
ACGCCGAAGAGTTTCTCAGTAATGAACAGGTTGAAAGACAACTGAAATCGGCGATGGAAAAATGGATCATTAACGTATTA
TCAGGCGGTGTAGAAGATATTGAACGTCTGATACAAATTCAGCATACCGTAGCCGAAGTCCATGCCCGAATTGGTATTCC
GGTGGAATTAGTCGAAATGGGATTTCGGGTACTGAAAAAATTGCTCTACCCGGTGATAAACGCCACCGACTACGGCTCAA
TGGAAAAGCTCCATATCTATCACTTTTCTATAAATAGTATTGATTTGGCCATGGAAGTAATGTCGCGCGCATTTTCGTTT
AGTGACAGCAGTGCCGCGAAAGAGGATGAAAACTATCGCATATTTTCACTACTGGAAAACGCAGAAGAAGAGAAAGAGCG
CCAAATTGGTGCACTGTTGGCCTGGGAGATCGATATCATTTATAAGGTACTACTGGATGCAGATCTGGGAAGCAGTTTGC
CCCTGAGTCAGGCTGACTTTGGTTTGTGGTTTAACCATAAAGGCCGCCATTATTTTAGTGGTATTGCCGAAGTCGGTCAT
ATTTCTCGCCTGATTCAGGATTTTGACGGTGTGTTTAATCACACACTAAATAACCCTAAAAATTTGAGTAACAGAAGCCT
GCGGGTGAAATTTTTATTACAAATCAGAAATACTGTTTCGCAAATTATTACTTTGCTACGCGAGCTATTTGAAGAGGTTT
CAAAACATGAAGTTGGCATGGATGTGCTAACAAAGTTACTTAATCGTCGCTTTTTGCCAACCATTTTTAAACGGGAAATA
GCCCACGCTAATCGTGTGTCTACCCCGCTTTCGACATTAATCATTGACGTCGATAAATTTAAAGAAATAAATGATACGTG
GGGCCATAACACGGGGGATGAGATTTTACGCAAAGTCTCTCAGGCCTTTTATGACAATGTCCGCAGTAGTGATTATGTGT
TTCGTTACGGTGGCGACGAGTTTGTTATTGTCCTTACCGAAGCCAGCGAAAATGACACCCTGCGTATTGCCGAGCGCATT
CGTAGCCGGGTAGAAAAAACGAAACTGAAAGCGGCCAATGGTGACGATATTCCCCTCTCATTATCAATAGGGGCCGCGAT
GTTTAATGGTCACCCGGATTATGAACGCTTAATCCAGATGGCGGATGAAGCGCTGTATATTGCAAAAAGGCGAGGTAGAA
ATCGTGTTGAACTATGGAAAGCAAGTCTTTAA

Upstream 100 bases:

>100_bases
ATAAAATTATCTACCATTAAACTACTCACACTCTTTTTATGTGTTGTGTTTCTTACGCAACCCGTCTTTTCAGTGAGCGC
AAAACGGTATAACCGTAAGG

Downstream 100 bases:

>100_bases
ATACCATCGGATGCAGAGGTAATCATGAAACTGACCGATGCAGAAAATAGTGATGACGGCATTTTCTTTCCCGCCCTTGA
ACAAAATATGATGGGCGCGG

Product: diguanylate cyclase YddV

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MGIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLSNEQVERQLKSAMEKWIINVL
SGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKKLLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSF
SDSSAAKEDENYRIFSLLENAEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGH
ISRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGMDVLTKLLNRRFLPTIFKREI
AHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERI
RSRVEKTKLKAANGDDIPLSLSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL

Sequences:

>Translated_463_residues
MGIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLSNEQVERQLKSAMEKWIINVL
SGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKKLLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSF
SDSSAAKEDENYRIFSLLENAEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGH
ISRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGMDVLTKLLNRRFLPTIFKREI
AHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERI
RSRVEKTKLKAANGDDIPLSLSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL
>Mature_462_residues
GIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLSNEQVERQLKSAMEKWIINVLS
GGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKKLLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFS
DSSAAKEDENYRIFSLLENAEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHI
SRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGMDVLTKLLNRRFLPTIFKREIA
HANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIR
SRVEKTKLKAANGDDIPLSLSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL

Specific function: Overexpression leads to an increased level of c-di-GMP, which leads to changes in the cell surface, to abnormal cell division, increased biofilm formation and decreased swimming (the latter 2 in strain W3110). In a strain able to produce cellulose (strain

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI145693134, Length=460, Percent_Identity=88.2608695652174, Blast_Score=846, Evalue=0.0,
Organism=Escherichia coli, GI87081881, Length=168, Percent_Identity=37.5, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786584, Length=163, Percent_Identity=35.5828220858896, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI87082007, Length=187, Percent_Identity=34.2245989304813, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1787262, Length=251, Percent_Identity=27.8884462151394, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787816, Length=159, Percent_Identity=32.7044025157233, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87081974, Length=169, Percent_Identity=33.1360946745562, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787056, Length=129, Percent_Identity=38.7596899224806, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787541, Length=157, Percent_Identity=32.484076433121, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788956, Length=154, Percent_Identity=34.4155844155844, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788085, Length=178, Percent_Identity=32.0224719101124, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787802, Length=131, Percent_Identity=33.587786259542, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788381, Length=184, Percent_Identity=31.5217391304348, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR012292
- InterPro:   IPR009050 [H]

Pfam domain/function: PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 53259; Mature: 53127

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLS
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
NEQVERQLKSAMEKWIINVLSGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFSDSSAAKEDENYRIFSLLEN
HHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
ISRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DVLTKLLNRRFLPTIFKREIAHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHEEHHHHHHHHHHCCCCCHHHHHHHHH
QAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIRSRVEKTKLKAANGDDIPLS
HHHHHCCCCCCEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL
EEECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
>Mature Secondary Structure 
GIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLS
CHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
NEQVERQLKSAMEKWIINVLSGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFSDSSAAKEDENYRIFSLLEN
HHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
ISRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DVLTKLLNRRFLPTIFKREIAHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHEEHHHHHHHHHHCCCCCHHHHHHHHH
QAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIRSRVEKTKLKAANGDDIPLS
HHHHHCCCCCCEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL
EEECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]