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The map label for this gene is dcp [H]

Identifier: 218548892

GI number: 218548892

Start: 1570398

End: 1572479

Strand: Direct

Name: dcp [H]

Synonym: EFER_1537

Alternate gene names: 218548892

Gene position: 1570398-1572479 (Clockwise)

Preceding gene: 218548888

Following gene: 218548894

Centisome position: 34.22

GC content: 48.41

Gene sequence:

>2082_bases
ATGCTTAACCTAAGGGGAAGAGCTGAACTGGAGCAAGATATGCCGAACACGAATCCATTTTTGAGCAAAAGCGTTTTACC
GTACCAGGCCCCGCATTTTGACCTGATTAAAGATAGCCATTACCGCCCTGCATTTGACGAAGGAATGCGACAGAAAAGGG
CAGAAATTGCGGCAATATTGCAAGTTAATGCCGCCCCCGATTTTACCAATACGATCCTCGCCCTGGAACAAAGCGGGGAA
TTATTAAACCGTGTTACCAGCGTATTCTTTGCCATGACGTCAGCACACACTAACGATGAGCTGCAACGGCTGGATGAAGA
GTTTTCTGCGGAACTGGCGCAGCTGGCGAATGAAATTTATCTCAATAGCGCATTGTTTGCGCGTGTTGATGAAGTCTGGC
AGGGACGGGCAGATCTGGAGCTGGATGCCGAGTCACTACGCTTGTTGGATGTGATCCACCAGCGTTTTGTGCTCGCAGGT
GCAAGACTCAATGAAAGCGACAAAGAACAACTGAAACGACTGAATACAGAAGCCGCTACACTTACCAGCCAGTTTAATCA
ACGCTTGTTGGCTGCCAGTAAGTCGGGCGGGCTAATCGTTGATGATATTGAGCAACTGGCGGGATTAAGCCCACAGGAAA
TCACCATTTGTGCAGATGCCGCCCATGAAAAAGGGTTGCATGATCGCTGGTTGATCCCGTTGATCAATACCACTCAACAA
CCGCTACTTGCTTCTTTACAGGATCGTCAGACCCGGAAAAATTTATTTGCCGCAGGATGGTCACGGGCAGAGAAAAACGA
TGCGAATGATACAAGAGCCCTTATTCAGCGTCTGGTTGAAATTCGTGCCCGTCAGGCGCAGTTGCTGGGATTTGAACATT
ACGCAGCATGGAAGATTTCCGACCAAATGGCTAAAACGCCTGAAGCAGCGCTAAATTTTATGCGTGAAATCGTTCCGGCT
GCACGTGAACGCGCACTGACGGAATGTGCGGATATTCAGCAGGTGATCGATGATGAGCAGGGGGGATTTACCGCTGAAGC
ATGGGACTGGGCGTTTTATGCCGAACAGGTTCGTAGGGAAAAATATGCTATTGATGAATCTCAGCTTAAACCTTACTTCG
TGCTTGATAACGTATTAGAAGAGGGCGTTTTCTGGACGGCAACTCAACTATTTGGTGTGCGTTTTGTCGAGCGCTATGAT
ATCCCGGTGTATCACCCTGATGTCCGGGTATGGGAAATATTCGACCATGATGGTGTCGGCATGGCATTGTTCTACGGTGA
TTTTTTTGCCCGAGACTCAAAAAGTGGTGGCGCATGGATGGGCAATTTTGTCGAACAATCTACACTTAATGAAACCCGGC
CAGTCATTTACAACGTCTGTAACTTCCAGAAACCTGCGGAAGGAGAAACCGCATTACTACTCTGGGATGATGTCATTACA
TTGTTCCATGAATTTGGGCACACATTGCATGGTTTGTTCGCCAGTCAGCGATACGCCACGCTTTCCGGCACAAATACACC
CCGTGACTTTGTAGAATTCCCGTCGCAGATAAATGAACACTGGGCTACCCATCCGCAGGTCTTTGCCCGCTATGCGCGTC
ATTATCTGTCAGGGGAAGCCATGCCTGAAACATTACGCGACAAGATGCTCAATGCCAGTTTGTTCAATAAGGGTTATGAG
ATGAGCGAGCTATTGAGTGCGGCTTTGCTGGATATGCGTTGGCACTGTCTTGAATCAGAAGAAGCCAGACAACACGTTGA
TATTTTTGAAAAACAAGCGCTTGTAGCGGAAGGTATGGATTTGCAGGCTGTGCCACCACGTTATCGCAGCAGTTACTTTG
CTCATATTTTTGGTGGCGGTTATGCAGCGGGATACTACGCCTATTTGTGGACGCAAATGCTGGCGGATGATGGCTATCAG
TGGTTTGTTGAACAAGGTGGCTTGAGCCGTGAAAATGGTCAGCGTTTCCGGGAAGATATTTTGTCTCGCGGAAACAGTTC
TGATCTGGAGCAACTGTATACCCGGTGGCGCGGTCATGCACCGCGTATTGAAGCGATGCTAAAAAATCGCGGACTGAGTT
AA

Upstream 100 bases:

>100_bases
TCATTTCACTGTTCCTCAGCACTTTTCGGAAGCTAATAACATAGCACGCGTTAACTGAGGGCGGGTAATAAGGATTACAA
CATTGCGCCTGTAACCGCCA

Downstream 100 bases:

>100_bases
GACAAGTACGGGCCTGACATTACGGCCCGTTTTTTTCATCCTGTCAGGGGAGTAAAAGCAGCAATTGTGCAAGGGCGAAG
CGAACAGATTGCGCCAGCAC

Product: dipeptidyl carboxypeptidase II

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MLNLRGRAELEQDMPNTNPFLSKSVLPYQAPHFDLIKDSHYRPAFDEGMRQKRAEIAAILQVNAAPDFTNTILALEQSGE
LLNRVTSVFFAMTSAHTNDELQRLDEEFSAELAQLANEIYLNSALFARVDEVWQGRADLELDAESLRLLDVIHQRFVLAG
ARLNESDKEQLKRLNTEAATLTSQFNQRLLAASKSGGLIVDDIEQLAGLSPQEITICADAAHEKGLHDRWLIPLINTTQQ
PLLASLQDRQTRKNLFAAGWSRAEKNDANDTRALIQRLVEIRARQAQLLGFEHYAAWKISDQMAKTPEAALNFMREIVPA
ARERALTECADIQQVIDDEQGGFTAEAWDWAFYAEQVRREKYAIDESQLKPYFVLDNVLEEGVFWTATQLFGVRFVERYD
IPVYHPDVRVWEIFDHDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNFQKPAEGETALLLWDDVIT
LFHEFGHTLHGLFASQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYLSGEAMPETLRDKMLNASLFNKGYE
MSELLSAALLDMRWHCLESEEARQHVDIFEKQALVAEGMDLQAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQ
WFVEQGGLSRENGQRFREDILSRGNSSDLEQLYTRWRGHAPRIEAMLKNRGLS

Sequences:

>Translated_693_residues
MLNLRGRAELEQDMPNTNPFLSKSVLPYQAPHFDLIKDSHYRPAFDEGMRQKRAEIAAILQVNAAPDFTNTILALEQSGE
LLNRVTSVFFAMTSAHTNDELQRLDEEFSAELAQLANEIYLNSALFARVDEVWQGRADLELDAESLRLLDVIHQRFVLAG
ARLNESDKEQLKRLNTEAATLTSQFNQRLLAASKSGGLIVDDIEQLAGLSPQEITICADAAHEKGLHDRWLIPLINTTQQ
PLLASLQDRQTRKNLFAAGWSRAEKNDANDTRALIQRLVEIRARQAQLLGFEHYAAWKISDQMAKTPEAALNFMREIVPA
ARERALTECADIQQVIDDEQGGFTAEAWDWAFYAEQVRREKYAIDESQLKPYFVLDNVLEEGVFWTATQLFGVRFVERYD
IPVYHPDVRVWEIFDHDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNFQKPAEGETALLLWDDVIT
LFHEFGHTLHGLFASQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYLSGEAMPETLRDKMLNASLFNKGYE
MSELLSAALLDMRWHCLESEEARQHVDIFEKQALVAEGMDLQAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQ
WFVEQGGLSRENGQRFREDILSRGNSSDLEQLYTRWRGHAPRIEAMLKNRGLS
>Mature_693_residues
MLNLRGRAELEQDMPNTNPFLSKSVLPYQAPHFDLIKDSHYRPAFDEGMRQKRAEIAAILQVNAAPDFTNTILALEQSGE
LLNRVTSVFFAMTSAHTNDELQRLDEEFSAELAQLANEIYLNSALFARVDEVWQGRADLELDAESLRLLDVIHQRFVLAG
ARLNESDKEQLKRLNTEAATLTSQFNQRLLAASKSGGLIVDDIEQLAGLSPQEITICADAAHEKGLHDRWLIPLINTTQQ
PLLASLQDRQTRKNLFAAGWSRAEKNDANDTRALIQRLVEIRARQAQLLGFEHYAAWKISDQMAKTPEAALNFMREIVPA
ARERALTECADIQQVIDDEQGGFTAEAWDWAFYAEQVRREKYAIDESQLKPYFVLDNVLEEGVFWTATQLFGVRFVERYD
IPVYHPDVRVWEIFDHDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNFQKPAEGETALLLWDDVIT
LFHEFGHTLHGLFASQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYLSGEAMPETLRDKMLNASLFNKGYE
MSELLSAALLDMRWHCLESEEARQHVDIFEKQALVAEGMDLQAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQ
WFVEQGGLSRENGQRFREDILSRGNSSDLEQLYTRWRGHAPRIEAMLKNRGLS

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=600, Percent_Identity=27.8333333333333, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI14149738, Length=621, Percent_Identity=26.8921095008052, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI156105687, Length=617, Percent_Identity=22.8525121555916, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=80.4411764705882, Blast_Score=1116, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=31.3411078717201, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319793, Length=668, Percent_Identity=25.5988023952096, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322715, Length=683, Percent_Identity=21.9619326500732, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356111, Length=564, Percent_Identity=25.531914893617, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI20129717, Length=402, Percent_Identity=26.3681592039801, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 79140; Mature: 79140

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLRGRAELEQDMPNTNPFLSKSVLPYQAPHFDLIKDSHYRPAFDEGMRQKRAEIAAIL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
QVNAAPDFTNTILALEQSGELLNRVTSVFFAMTSAHTNDELQRLDEEFSAELAQLANEIY
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LNSALFARVDEVWQGRADLELDAESLRLLDVIHQRFVLAGARLNESDKEQLKRLNTEAAT
HHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHH
LTSQFNQRLLAASKSGGLIVDDIEQLAGLSPQEITICADAAHEKGLHDRWLIPLINTTQQ
HHHHHHHHHHHHCCCCCEEHCCHHHHHCCCCCEEEEEECCHHHCCCCCCEEEECCCCCCH
PLLASLQDRQTRKNLFAAGWSRAEKNDANDTRALIQRLVEIRARQAQLLGFEHYAAWKIS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHEEEEC
DQMAKTPEAALNFMREIVPAARERALTECADIQQVIDDEQGGFTAEAWDWAFYAEQVRRE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
KYAIDESQLKPYFVLDNVLEEGVFWTATQLFGVRFVERYDIPVYHPDVRVWEIFDHDGVG
HHCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCE
MALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNFQKPAEGETALLLWDDVIT
EEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEEHHHHHH
LFHEFGHTLHGLFASQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYLSGEA
HHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
MPETLRDKMLNASLFNKGYEMSELLSAALLDMRWHCLESEEARQHVDIFEKQALVAEGMD
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LQAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLSRENGQRFREDI
CCCCCCHHHCCCEEHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHH
LSRGNSSDLEQLYTRWRGHAPRIEAMLKNRGLS
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLNLRGRAELEQDMPNTNPFLSKSVLPYQAPHFDLIKDSHYRPAFDEGMRQKRAEIAAIL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
QVNAAPDFTNTILALEQSGELLNRVTSVFFAMTSAHTNDELQRLDEEFSAELAQLANEIY
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LNSALFARVDEVWQGRADLELDAESLRLLDVIHQRFVLAGARLNESDKEQLKRLNTEAAT
HHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHH
LTSQFNQRLLAASKSGGLIVDDIEQLAGLSPQEITICADAAHEKGLHDRWLIPLINTTQQ
HHHHHHHHHHHHCCCCCEEHCCHHHHHCCCCCEEEEEECCHHHCCCCCCEEEECCCCCCH
PLLASLQDRQTRKNLFAAGWSRAEKNDANDTRALIQRLVEIRARQAQLLGFEHYAAWKIS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHEEEEC
DQMAKTPEAALNFMREIVPAARERALTECADIQQVIDDEQGGFTAEAWDWAFYAEQVRRE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
KYAIDESQLKPYFVLDNVLEEGVFWTATQLFGVRFVERYDIPVYHPDVRVWEIFDHDGVG
HHCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCE
MALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNFQKPAEGETALLLWDDVIT
EEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEEHHHHHH
LFHEFGHTLHGLFASQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYLSGEA
HHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
MPETLRDKMLNASLFNKGYEMSELLSAALLDMRWHCLESEEARQHVDIFEKQALVAEGMD
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LQAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLSRENGQRFREDI
CCCCCCHHHCCCEEHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHH
LSRGNSSDLEQLYTRWRGHAPRIEAMLKNRGLS
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]