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The map label for this gene is rspB [H]

Identifier: 218548881

GI number: 218548881

Start: 1559905

End: 1560948

Strand: Direct

Name: rspB [H]

Synonym: EFER_1526

Alternate gene names: 218548881

Gene position: 1559905-1560948 (Clockwise)

Preceding gene: 218548880

Following gene: 218548882

Centisome position: 33.99

GC content: 44.92

Gene sequence:

>1044_bases
GTGGAACTGGTAAGGAAGACGATGATGGTGAGTGTTGTAGTTGAAAAACCAGGCCAAATGTGTCTGGTAGAAAGTGTTAA
ATCTGAACCTAAAGCCGATGAGGTTTGCGTAAAGGTCGAATATGCAGGGATTTGTGGTTCAGATCTGCACATTTATCACG
GGGCTAATCCATTTGCAGTTTATCCACGCATTGTTGGTCACGAATTTGTGGGTACGATAATCCAGGTTGGCGAGAATATC
GATCCGCTGCGTATAGGCGAGCGAGTCGTGGTCGATCCGGTCATTAGCTGCGGTCATTGCTACCCGTGCTCAATTGGGCG
ACCAAATGTCTGTGAAAGCCTCAATGTATTGGGTGTTCATCGCGATGGCGGCTTTACTGAATATACATGTGTACCGGCAA
CAAATGCTTATCCGGTGCCTGAAGATATTCCGGCAAATATAGCTGTAACAATCGAACCTTATGCCGTCGCAGCCAACGTA
ACAAATCGTACTGGCGTTTATCCTACCGATATTGCACTGGTTTATGGAGCAGGCCCGGCGGGGATGACGATAATTGATGT
GTTACGTAATGTCTGGCAAATTCCAGTGATTGTGGTTGATCAGCGTGAAGATCGACTGGAAAGTGCACGTCGTTGTGGTG
CGACGTATACTTTCAATAACCGGAACGGTTCATTACGTGAATATCTGGCAAGTGAAAAAATTACGCCAACGTTAATTATC
GATGCGGTATGTCATCCATCCATCCTTGAAGAGGCCGTTACGCTAATTTCCTCTGCAGGACGAATCGGTCTTTTAGGTTT
TTCTGCGACGCCGTCCGCAATAGCGCAACAAGAATTAACACGTCGTGAGTTAACCCTCTATTCATCGCGATTAAATTGTC
GTATGTTCCCTACGGTTATCGAATGGATGCAACATAATCTAATTCACCCGGAGAATATTATAAGTCACGTTTTTGATATT
CACCATGTGGACGAAGCCTTTAAACTTATAGAGTCCCAACAAGAAGGTCTTTGCAAAGTATTATTAAAGTTTCCCGAATC
CTGA

Upstream 100 bases:

>100_bases
ACAAACCGGGCCTTGGCATTGAATTTGACGAAAAACTGGCAGCGAAATATCCATACGAACCTGCTTATTTGCCTGTTGCT
CGTCTGGAAGACGGTACTCT

Downstream 100 bases:

>100_bases
CCCTCATTTATAAAAACAACTGTACCTACAAGGAACATAGATCATGGAAAAGAAAAAACTGTCACTGGCTCTTTGTACGC
TGTTTGGCGGGTTATTAAGT

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MELVRKTMMVSVVVEKPGQMCLVESVKSEPKADEVCVKVEYAGICGSDLHIYHGANPFAVYPRIVGHEFVGTIIQVGENI
DPLRIGERVVVDPVISCGHCYPCSIGRPNVCESLNVLGVHRDGGFTEYTCVPATNAYPVPEDIPANIAVTIEPYAVAANV
TNRTGVYPTDIALVYGAGPAGMTIIDVLRNVWQIPVIVVDQREDRLESARRCGATYTFNNRNGSLREYLASEKITPTLII
DAVCHPSILEEAVTLISSAGRIGLLGFSATPSAIAQQELTRRELTLYSSRLNCRMFPTVIEWMQHNLIHPENIISHVFDI
HHVDEAFKLIESQQEGLCKVLLKFPES

Sequences:

>Translated_347_residues
MELVRKTMMVSVVVEKPGQMCLVESVKSEPKADEVCVKVEYAGICGSDLHIYHGANPFAVYPRIVGHEFVGTIIQVGENI
DPLRIGERVVVDPVISCGHCYPCSIGRPNVCESLNVLGVHRDGGFTEYTCVPATNAYPVPEDIPANIAVTIEPYAVAANV
TNRTGVYPTDIALVYGAGPAGMTIIDVLRNVWQIPVIVVDQREDRLESARRCGATYTFNNRNGSLREYLASEKITPTLII
DAVCHPSILEEAVTLISSAGRIGLLGFSATPSAIAQQELTRRELTLYSSRLNCRMFPTVIEWMQHNLIHPENIISHVFDI
HHVDEAFKLIESQQEGLCKVLLKFPES
>Mature_347_residues
MELVRKTMMVSVVVEKPGQMCLVESVKSEPKADEVCVKVEYAGICGSDLHIYHGANPFAVYPRIVGHEFVGTIIQVGENI
DPLRIGERVVVDPVISCGHCYPCSIGRPNVCESLNVLGVHRDGGFTEYTCVPATNAYPVPEDIPANIAVTIEPYAVAANV
TNRTGVYPTDIALVYGAGPAGMTIIDVLRNVWQIPVIVVDQREDRLESARRCGATYTFNNRNGSLREYLASEKITPTLII
DAVCHPSILEEAVTLISSAGRIGLLGFSATPSAIAQQELTRRELTLYSSRLNCRMFPTVIEWMQHNLIHPENIISHVFDI
HHVDEAFKLIESQQEGLCKVLLKFPES

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=26.1363636363636, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI71565154, Length=222, Percent_Identity=27.4774774774775, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=20.8672086720867, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=19.6675900277008, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI262073058, Length=345, Percent_Identity=24.3478260869565, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71743840, Length=345, Percent_Identity=24.3478260869565, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4501929, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4501933, Length=219, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI34577061, Length=219, Percent_Identity=26.9406392694064, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=55.4572271386431, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=28.8629737609329, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=26.8011527377522, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790045, Length=322, Percent_Identity=28.8819875776398, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788407, Length=298, Percent_Identity=30.8724832214765, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=25.3164556962025, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786825, Length=368, Percent_Identity=26.6304347826087, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=26.5582655826558, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788075, Length=316, Percent_Identity=24.0506329113924, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=263, Percent_Identity=25.4752851711027, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786518, Length=274, Percent_Identity=24.4525547445255, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=22.9281767955801, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082401, Length=132, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=327, Percent_Identity=30.2752293577982, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562878, Length=324, Percent_Identity=26.5432098765432, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=115, Percent_Identity=33.9130434782609, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=135, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=153, Percent_Identity=32.0261437908497, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=23.2091690544413, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=351, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=218, Percent_Identity=32.1100917431193, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=26.5536723163842, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=212, Percent_Identity=29.7169811320755, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=353, Percent_Identity=24.0793201133144, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=353, Percent_Identity=23.7960339943343, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=362, Percent_Identity=22.3756906077348, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=169, Percent_Identity=30.1775147928994, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=115, Percent_Identity=33.9130434782609, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=115, Percent_Identity=33.0434782608696, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=138, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737897, Length=319, Percent_Identity=25.705329153605, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17137530, Length=319, Percent_Identity=24.4514106583072, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550770, Length=343, Percent_Identity=22.4489795918367, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221457811, Length=343, Percent_Identity=22.4489795918367, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551930, Length=343, Percent_Identity=22.4489795918367, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737895, Length=351, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 38213; Mature: 38213

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVRKTMMVSVVVEKPGQMCLVESVKSEPKADEVCVKVEYAGICGSDLHIYHGANPFAV
CHHHHHHHHHEEEECCCCCEEEHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEE
YPRIVGHEFVGTIIQVGENIDPLRIGERVVVDPVISCGHCYPCSIGRPNVCESLNVLGVH
CHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECHHHHCCCCCCCCCCCCCHHCCCCEEEEE
RDGGFTEYTCVPATNAYPVPEDIPANIAVTIEPYAVAANVTNRTGVYPTDIALVYGAGPA
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCC
GMTIIDVLRNVWQIPVIVVDQREDRLESARRCGATYTFNNRNGSLREYLASEKITPTLII
CHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHEEE
DAVCHPSILEEAVTLISSAGRIGLLGFSATPSAIAQQELTRRELTLYSSRLNCRMFPTVI
ECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEECHHHH
EWMQHNLIHPENIISHVFDIHHVDEAFKLIESQQEGLCKVLLKFPES
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELVRKTMMVSVVVEKPGQMCLVESVKSEPKADEVCVKVEYAGICGSDLHIYHGANPFAV
CHHHHHHHHHEEEECCCCCEEEHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCEE
YPRIVGHEFVGTIIQVGENIDPLRIGERVVVDPVISCGHCYPCSIGRPNVCESLNVLGVH
CHHHHHHHHHHHHHHHCCCCCCHHCCCEEEECHHHHCCCCCCCCCCCCCHHCCCCEEEEE
RDGGFTEYTCVPATNAYPVPEDIPANIAVTIEPYAVAANVTNRTGVYPTDIALVYGAGPA
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECEEEEEECCCCCCCCCCCEEEEEECCCC
GMTIIDVLRNVWQIPVIVVDQREDRLESARRCGATYTFNNRNGSLREYLASEKITPTLII
CHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCHHEEE
DAVCHPSILEEAVTLISSAGRIGLLGFSATPSAIAQQELTRRELTLYSSRLNCRMFPTVI
ECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEECHHHH
EWMQHNLIHPENIISHVFDIHHVDEAFKLIESQQEGLCKVLLKFPES
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]