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The map label for this gene is sdaA [H]

Identifier: 218548628

GI number: 218548628

Start: 1300230

End: 1301594

Strand: Reverse

Name: sdaA [H]

Synonym: EFER_1262

Alternate gene names: 218548628

Gene position: 1301594-1300230 (Counterclockwise)

Preceding gene: 218548629

Following gene: 218548627

Centisome position: 28.37

GC content: 52.97

Gene sequence:

>1365_bases
GTGATTAGTCTATTCGACATGTTTAAGGTGGGGATTGGTCCCTCATCTTCCCATACTGTAGGGCCTATGAAGGCAGGTAA
ACAGTTCGTCGATGATCTGGTCGAAAAAGGCTTACTGGATAGCGTTACCCGCGTTGCCGTGGACGTTTATGGTTCACTGT
CGCTGACGGGTAAAGGCCACCATACCGATATCGCCATTATTATGGGGCTTGCAGGTAACGAACCTGCTACCGTGGATATC
GACAGTATTCCCGGTTTTATTCGCGACGTAGAAGAGCGCGAACGTTTGCTGCTGGCACAGGGTCGGCATGAAGTGGATTT
TCCGCGTGACAACGGGATGCGTTTTCATAACGGCAACCTGCCGCTGCATGAAAACGGGATGCAGATCCACGCGTATAATG
GCGATAAAGTTGTTTACAGCAAAACTTATTATTCCATCGGCGGCGGTTTTATCGTCGATGAAGAACATTTTGGTCATGAT
GCCGCCAACGAAGTCAGTGTGCCGTATCCGTTCAAATCCGCCACCGAACTGCTGGCTTACTGCAATGAGACCGGTTATTC
CCTTTCCGGCCTGGCTATGCAGAATGAGCTGGCATTGCACAGCAAGAAAGAGATCGACGAGTTTTTCGCTCATGTCTGGC
AAACCATGCAGGCTTGTATCGATCGCGGCATGAACACCGAAGGGGTATTGCCAGGCCCGCTGCGCGTTCCCCGCCGTGCG
TCGGCGCTGCGCCGGATGCTGGTTTCCAGCGATAAACTGTCTAACGATCCGATGAATGTCATCGACTGGGTAAACATGTT
TGCGCTGGCGGTGAACGAAGAGAACGCCGCAGGTGGCCGCGTGGTGACTGCACCAACCAACGGTGCTTGTGGTATTGTTC
CGGCGGTACTGGCTTACTATGACCACTTTATTGAATCTGTCAGCCCGGATATCTATACCCGCTACTTTATGGCTGCGGGC
GCGATTGGCGCACTCTATAAAATGAACGCCTCTATCTCGGGTGCGGAAGTCGGTTGCCAGGGCGAAGTGGGTGTTGCCTG
TTCAATGGCTGCTGCGGGTCTTGCAGAACTGCTGGGCGGTAGCCCGGAACAGGTTTGCGTAGCGGCAGAAATTGGCATGG
AACACAACCTTGGTTTAACCTGCGACCCGGTTGCTGGACAAGTTCAGGTGCCGTGCATTGAGCGTAATGCCATTGCCTCT
GTGAAAGCGATCAATGCCGCACGCATGGCCTTACGCCGCACCAGTGCACCGCGCGTCTCGCTGGATAAGGTCATCGAAAC
AATGTATGAAACCGGGAAAGATATGAACGCTAAATACCGTGAAACTTCTCGCGGTGGTCTGGCGATTAAAGTCCAGTGTG
ACTAA

Upstream 100 bases:

>100_bases
TTCATGTGAATAGTTAAACTGATCGCCGCGTTCCCTCTTACACTATGCGCTGTAATTAGCTCGTTACTGGAAGCCCAGTC
ACCTTGTCAGGAGTATTATC

Downstream 100 bases:

>100_bases
TACTTTTCCTTCGCCCATCTGCAACGGATGGGCGAATTTACCCCTGCTTTCTCGTCTGCTGTAATTTTCCCCACTACACT
TCCACTGTTGCGTCAGGCAT

Product: L-serine deaminase I

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNEPATVDI
DSIPGFIRDVEERERLLLAQGRHEVDFPRDNGMRFHNGNLPLHENGMQIHAYNGDKVVYSKTYYSIGGGFIVDEEHFGHD
AANEVSVPYPFKSATELLAYCNETGYSLSGLAMQNELALHSKKEIDEFFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRA
SALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYTRYFMAAG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Sequences:

>Translated_454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNEPATVDI
DSIPGFIRDVEERERLLLAQGRHEVDFPRDNGMRFHNGNLPLHENGMQIHAYNGDKVVYSKTYYSIGGGFIVDEEHFGHD
AANEVSVPYPFKSATELLAYCNETGYSLSGLAMQNELALHSKKEIDEFFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRA
SALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYTRYFMAAG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
>Mature_454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNEPATVDI
DSIPGFIRDVEERERLLLAQGRHEVDFPRDNGMRFHNGNLPLHENGMQIHAYNGDKVVYSKTYYSIGGGFIVDEEHFGHD
AANEVSVPYPFKSATELLAYCNETGYSLSGLAMQNELALHSKKEIDEFFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRA
SALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYTRYFMAAG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGGSPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMALRRTSAPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=99.3392070484581, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=455, Percent_Identity=77.3626373626374, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=73.7306843267108, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48899; Mature: 48899

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSVTRVAVDVYGSLSLTGKGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNEPATVDIDSIPGFIRDVEERERLLLAQGRHEVDFPRDNGMRFHNGNL
CCEEEEEEEECCCCCCEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
PLHENGMQIHAYNGDKVVYSKTYYSIGGGFIVDEEHFGHDAANEVSVPYPFKSATELLAY
CEECCCCEEEEECCCEEEEEEEEEECCCCEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHH
CNETGYSLSGLAMQNELALHSKKEIDEFFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRA
HCCCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIESVSPDIYTRYFMAAGAIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMALRRTSAPRVS
CCHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCC
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLDSVTRVAVDVYGSLSLTGKGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNEPATVDIDSIPGFIRDVEERERLLLAQGRHEVDFPRDNGMRFHNGNL
CCEEEEEEEECCCCCCEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
PLHENGMQIHAYNGDKVVYSKTYYSIGGGFIVDEEHFGHDAANEVSVPYPFKSATELLAY
CEECCCCEEEEECCCEEEEEEEEEECCCCEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHH
CNETGYSLSGLAMQNELALHSKKEIDEFFAHVWQTMQACIDRGMNTEGVLPGPLRVPRRA
HCCCCCCEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIESVSPDIYTRYFMAAGAIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGG
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMALRRTSAPRVS
CCHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCC
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]