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The map label for this gene is macA [H]

Identifier: 218548401

GI number: 218548401

Start: 1053252

End: 1054367

Strand: Direct

Name: macA [H]

Synonym: EFER_1026

Alternate gene names: 218548401

Gene position: 1053252-1054367 (Clockwise)

Preceding gene: 218548398

Following gene: 218548402

Centisome position: 22.95

GC content: 50.36

Gene sequence:

>1116_bases
ATGCGAATGAGGGAAAGGTTTAAAAAACGTTATCTGATAGCAGCCATTGTTATTTTGGGTGGGCTTATGGTGCTCTGGAA
AACGCTGAATGCGCCAGAGCCGAAATATCAGACATTAATTGTGCGCCCAGGAGAGCTACAGCAAAGTGTGCTGGCCACCG
GAAAGCTGGATGCATTACGTAAAGTCGATGTTGGTGCACAGGTGAGCGGTCAGTTGAAAACGCTGTCGGTAGCTATTGGT
GACAAAGTCAAAAAAGATCAGCTACTGGGGATTATCGATCCTGAACAGGCGCAAAACCAGATTAAAGAAGTGGAAGCGAC
GCTAATGGAGCTGCGGGCGCAACGTCAGCAGGCCGAGGCCGAACTGAAACTGGCACGGGTAACGTTATCCCGCCAACAGA
AACTGGCGCAAACCCAGGCAATCTCACAACAGGATCTGGATACCGCAGTGACAGAGTTGGCGGTGAAGCAGGCTCAGATT
GGCACCATCGATGCGCAAATTAAGCGTAACCAGGCATCACTGGATACCGCTAAAACTAATCTCGATTACACCCGAATTGT
GGCCCCGATGGCTGGCGAAGTGACGCAAATCACCACGCTTCAAGGCCAGACGGTCATTGCTGCTCAGCAGGCTCCAAACA
TTCTGACGCTGGCAGATATGAGCACTATGTTGGTAAAGGCTCAGGTTTCAGAAGCGGATGTTATTCATCTAAAACCGGGG
CAAAAGGCATGGTTCACTGTGTTGGGCGATCCACAAACACGTTACGAGGGGCGAATCAAAGATGTTCTGCCGACCCCAGA
AAAAGTTAACGATGCTATTTTTTATTACGCCCGTTTTGAGGTGCCAAATCCGCAAGGCGTGCTGCGTCTCGATATGACAG
CCCAGGTGCATATTCAGCTTGCCGAAGTAAAAAATGTACTGACTATTCCGCTGTCTGCACTGGGCGATCCCGTGGGAGAT
AACCGTTATAAAGTCACTTTGTTACGCAATGGCGAAACCCGGGAACGGGAAGTGGTTATTGGTGCCCGTAACGACACCGA
TGTGGAAATTGTTAAAGGACTGGAAGCGGGCGACGAAGTGGTGATCGGTGAAGGGAATCCCGGAGCAGCAAAATGA

Upstream 100 bases:

>100_bases
CAATAAAGCGATTACTCACCGTGACTTTGTGGTTTTGTTGATGTTTGGTTGAAGTTTTACTGTTCATACAGGTGAGAACG
ACGATGAATTCAGGAGCTGT

Downstream 100 bases:

>100_bases
CGCCACTGCTTGAACTCAGTAATATCCGCCGCAGCTTCCCATCAGGCGAAGACGTGGTTGAGGTGCTTAAAGGGATCAAC
CTGACAATCAATGCCGGGGA

Product: macrolide transporter subunit MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MRMRERFKKRYLIAAIVILGGLMVLWKTLNAPEPKYQTLIVRPGELQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIG
DKVKKDQLLGIIDPEQAQNQIKEVEATLMELRAQRQQAEAELKLARVTLSRQQKLAQTQAISQQDLDTAVTELAVKQAQI
GTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPG
QKAWFTVLGDPQTRYEGRIKDVLPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQLAEVKNVLTIPLSALGDPVGD
NRYKVTLLRNGETREREVVIGARNDTDVEIVKGLEAGDEVVIGEGNPGAAK

Sequences:

>Translated_371_residues
MRMRERFKKRYLIAAIVILGGLMVLWKTLNAPEPKYQTLIVRPGELQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIG
DKVKKDQLLGIIDPEQAQNQIKEVEATLMELRAQRQQAEAELKLARVTLSRQQKLAQTQAISQQDLDTAVTELAVKQAQI
GTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPG
QKAWFTVLGDPQTRYEGRIKDVLPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQLAEVKNVLTIPLSALGDPVGD
NRYKVTLLRNGETREREVVIGARNDTDVEIVKGLEAGDEVVIGEGNPGAAK
>Mature_371_residues
MRMRERFKKRYLIAAIVILGGLMVLWKTLNAPEPKYQTLIVRPGELQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIG
DKVKKDQLLGIIDPEQAQNQIKEVEATLMELRAQRQQAEAELKLARVTLSRQQKLAQTQAISQQDLDTAVTELAVKQAQI
GTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPG
QKAWFTVLGDPQTRYEGRIKDVLPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQLAEVKNVLTIPLSALGDPVGD
NRYKVTLLRNGETREREVVIGARNDTDVEIVKGLEAGDEVVIGEGNPGAAK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=371, Percent_Identity=89.4878706199461, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI87082036, Length=315, Percent_Identity=26.3492063492064, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789929, Length=372, Percent_Identity=21.7741935483871, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40738; Mature: 40738

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRERFKKRYLIAAIVILGGLMVLWKTLNAPEPKYQTLIVRPGELQQSVLATGKLDALR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCHHHHH
KVDVGAQVSGQLKTLSVAIGDKVKKDQLLGIIDPEQAQNQIKEVEATLMELRAQRQQAEA
HCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKLARVTLSRQQKLAQTQAISQQDLDTAVTELAVKQAQIGTIDAQIKRNQASLDTAKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHHHHCC
LDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPG
CCHHEEECCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHEEEECCCCCEEEECCC
QKAWFTVLGDPQTRYEGRIKDVLPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQL
CCEEEEEECCCCCCCCCCHHHCCCCCCCCCCEEEEEEEEECCCCCCEEEEECEEEEEEEE
AEVKNVLTIPLSALGDPVGDNRYKVTLLRNGETREREVVIGARNDTDVEIVKGLEAGDEV
EHHCCEEEEEHHHCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHEECCCCCCEE
VIGEGNPGAAK
EEECCCCCCCC
>Mature Secondary Structure
MRMRERFKKRYLIAAIVILGGLMVLWKTLNAPEPKYQTLIVRPGELQQSVLATGKLDALR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCHHHHH
KVDVGAQVSGQLKTLSVAIGDKVKKDQLLGIIDPEQAQNQIKEVEATLMELRAQRQQAEA
HCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKLARVTLSRQQKLAQTQAISQQDLDTAVTELAVKQAQIGTIDAQIKRNQASLDTAKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHHHHCC
LDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSTMLVKAQVSEADVIHLKPG
CCHHEEECCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHEEEECCCCCEEEECCC
QKAWFTVLGDPQTRYEGRIKDVLPTPEKVNDAIFYYARFEVPNPQGVLRLDMTAQVHIQL
CCEEEEEECCCCCCCCCCHHHCCCCCCCCCCEEEEEEEEECCCCCCEEEEECEEEEEEEE
AEVKNVLTIPLSALGDPVGDNRYKVTLLRNGETREREVVIGARNDTDVEIVKGLEAGDEV
EHHCCEEEEEHHHCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHEECCCCCCEE
VIGEGNPGAAK
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]