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The map label for this gene is nuoN [H]

Identifier: 218548275

GI number: 218548275

Start: 910268

End: 911545

Strand: Direct

Name: nuoN [H]

Synonym: EFER_0894

Alternate gene names: 218548275

Gene position: 910268-911545 (Clockwise)

Preceding gene: 218548274

Following gene: 218548276

Centisome position: 19.84

GC content: 57.12

Gene sequence:

>1278_bases
ATGGACGTTACGCCGCTGATGCGCGTTGATGGTTTCGCCATGCTTTACACTGGGCTTGTATTGTTGGCGAGCCTCGCCAC
CTGTACTTTCGCCTACCCGTGGCTTGAAGGCTATAACGACAACAAGGACGAGTTCTACCTGTTGGTGTTAATTGCCGCTC
TGGGCGGGATCCTGCTGGCGAATGCCAATCACCTGGCGTCTCTGTTCCTCGGTATTGAACTGATCTCTCTGCCGCTGTTT
GGCCTGGTCGGTTACGCTTTCCGCCAGAAACGTTCGCTGGAAGCCAGTATCAAATACACCATCCTTTCTGCTGCAGCGTC
TTCTTTCCTGCTGTTTGGTATGGCACTGGTGTACGCGCAGTCTGGCGACCTGTCGTTCGTTGCACTGGGTAAAAACCTTG
GCGACGGCATGCTCAACGAGCCGCTGTTGCTGGCAGGTTTTGGCCTGATGATTGTCGGCCTCGGCTTCAAGCTCTCTCTG
GTGCCGTTCCACCTGTGGACGCCAGACGTATACCAGGGCGCGCCTGCGCCGGTTTCTACCTTCCTGGCGACGGCGAGCAA
AATCGCTATCTTCGGCGTGGTGATGCGTCTGTTCCTCTACGCACCAGTGGGTGATAGCGAAGCGATTCGCGTGGTGCTGG
CGATTATCGCCTTTGCCTCTATCATCTTCGGTAACCTGATGGCACTGAGCCAGACCAATATCAAACGTCTGCTCGGTTAC
TCGTCTATCTCTCACCTCGGCTATCTGCTGGTGGCGCTGATTGCGCTGCAAACTGGCGAGATGTCGATGGAAGCGGTAGG
GGTTTACCTGGCCGGTTATCTGTTCAGCAGCCTCGGCGCATTTGGCGTAGTCAGCCTGATGTCCAGCCCGTACCGTGGCC
CGGATGCTGATTCCCTGTTCTCTTACCGCGGTCTGTTCTGGCATCGTCCGATCCTCGCGGCAGTGATGACGGTGATGATG
CTGTCTCTGGCGGGTATCCCAATGACGCTGGGCTTTATCGGTAAGTTCTATGTGCTGGCGGTCGGTGTCCAGGCACACTT
GTGGTGGCTGGTGGGCGCGGTGGTTGTCGGTTCGGCAATCGGCCTCTACTACTACCTGCGCGTAGCGGTGAGCTTATACC
TGCACGCCCCGGAGCAACCGGGTCGCGATGCACCGTCAAACTGGCAGTACAGCGCAGGTGGTATCGTGGTGCTGATCTCT
GCACTGTTGGTACTGGTGCTGGGTGTATGGCCGCAACCGCTGATTAGCATTGTGCGGTTAGCAATGCCGCTGATGTAA

Upstream 100 bases:

>100_bases
CATTGCGTGGCGACGCAATCATTTCCTCAACGCTACGCTCTCGGTTATTGGGCTTAACGCGGCGCTGGTTTCGCTCTGGT
TTGTCGGCCAGGCGGGCGCT

Downstream 100 bases:

>100_bases
GGTTGAGTGTTGATGTAAAAAAACCGCCGATTTCGGCGGTTTTTTTATGGTGTTAATTGTTGCTAATAAAAAGAACATAT
AAATCTATATCTGCGTCGAA

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLF
GLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSL
VPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGY
SSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMM
LSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLIS
ALLVLVLGVWPQPLISIVRLAMPLM

Sequences:

>Translated_425_residues
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLF
GLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSL
VPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGY
SSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMM
LSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLIS
ALLVLVLGVWPQPLISIVRLAMPLM
>Mature_425_residues
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLF
GLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSL
VPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGY
SSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMM
LSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLIS
ALLVLVLGVWPQPLISIVRLAMPLM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=374, Percent_Identity=20.5882352941176, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI251831108, Length=321, Percent_Identity=21.183800623053, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI145693160, Length=425, Percent_Identity=100, Blast_Score=832, Evalue=0.0,
Organism=Escherichia coli, GI1788831, Length=205, Percent_Identity=32.6829268292683, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788829, Length=331, Percent_Identity=25.0755287009063, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788613, Length=355, Percent_Identity=27.0422535211268, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788827, Length=323, Percent_Identity=27.8637770897833, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788614, Length=393, Percent_Identity=26.2086513994911, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45651; Mature: 45651

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLA
CCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
NANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHHH
FLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AMPLM
HHCCC
>Mature Secondary Structure
MDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLA
CCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
NANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVST
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHHH
FLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSISHLGYLLVALIALQTGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AMPLM
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA