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The map label for this gene is hisC1 [H]

Identifier: 218235825

GI number: 218235825

Start: 1502886

End: 1503998

Strand: Direct

Name: hisC1 [H]

Synonym: BCB4264_A1574

Alternate gene names: 218235825

Gene position: 1502886-1503998 (Clockwise)

Preceding gene: 218233700

Following gene: 218235224

Centisome position: 27.73

GC content: 36.12

Gene sequence:

>1113_bases
ATGAGAGTGAAAGAGCAATTGTTAACTTTGAGAGCGTATGTGCCTGGGAAAAACATTGAAGAAGTAAAAAGAGAATATGG
TTTATCAAAAATTGTGAAATTAGCATCCAACGAAAATCCATTCGGTTGCTCAGCACGTGTGACGGAAGCATTAACTTCTT
TAGCGAGCCAATATGCCCTTTATCCAGATGGATATGCCTTTGAACTTCGGACAAAAGTAGCGGAACATTTAGGTGTAAAA
GCAGAACAACTACTATTTGGTAGTGGATTAGATGAAGTCATTCAAATGATTAGCCGAGCGTTACTACATGAAGGAACAAA
CGTTGTAATGGCGAATCCTACGTTTTCACAATATCATCACCATGCTGTTATTGAAGGAGCAGAAGTTCGTGAAGTATCAC
TTAAAGATGGTATTCACGATTTAGATGCAATGCTAGAGCAAGTAGATGAGAAAACGAAAATTGTATGGATTTGTAATCCG
AATAATCCAACAGGTACATATGTTGAGAAACAAAAATTACTTTCATTTTTAGAATCAGTTCCTAAGTCGGCTCTCGTTAT
TATGGACGAAGCATATTATGAATACGCGGAAGCAGAAGACTATCCGCAAACATTACCACTTCTTGAAAAGTATGAAAATC
TTATGGTTTTACGCACGTTTTCAAAAGCATATGGTTTAGCTGCTTTTCGTATCGGATATGCGATTGGGGATGCGAAGTTA
ATCGGACAGCTAGAAGTAGCTAGGTTACCATTCAATACATCAACTGTAGCCCAATCTGTAGCACTCGCTGCATTAGAAGA
TCAAGCTTTTTTACAAGATTGTGTGCAAAAGAATGCTGAAGGTTTAAATCAGTATTATGCATTTTGTAAAGAATATAACG
TATTCTATTATCCATCTCAAACAAATTTCATTTTCTTAAAACTCGGTATACCAGGTAATGAAGCTTTCGAACGATTAATG
AAAAAAGGATATATCGTTCGTTCTGGTGCTGCATTTGGTATCGATGATGGTATTCGTATTACTGTCGGTTTGAAGGAAGA
AAATGATGAAATTATAGAGTTACTGAAAGAGCTTGTAAATGAGCAAGTACAGAAAGAAGAAACATATTCTTAA

Upstream 100 bases:

>100_bases
AGAGGTATTCTCGTAATAGTGACGGTTATGACAAAAGATTACAGTAAGGGGCTATAACCGTATTGTAATCAAATTGAATG
AAATGACTGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
GAGATTGTGAAGGCTCCTATTATAGGAGCCTTTTTTATCGCATTCAAAATAAAGGTTGAAGACTGCTAATTAAGTTATTC
TGTAAACCACGGTTTGTATG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGYAFELRTKVAEHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLEQVDEKTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAEAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAIGDAKL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQDCVQKNAEGLNQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Sequences:

>Translated_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGYAFELRTKVAEHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLEQVDEKTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAEAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAIGDAKL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQDCVQKNAEGLNQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS
>Mature_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGYAFELRTKVAEHLGVK
AEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLEQVDEKTKIVWICNP
NNPTGTYVEKQKLLSFLESVPKSALVIMDEAYYEYAEAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAIGDAKL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQDCVQKNAEGLNQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=30.5232558139535, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788722, Length=205, Percent_Identity=31.219512195122, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788627, Length=237, Percent_Identity=24.4725738396624, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=331, Percent_Identity=28.0966767371601, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41606; Mature: 41606

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGYAFELRTKVAEHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCEEEHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLEQVDEKTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCHHEEEHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAEAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAIGDAKL
CCCEEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQDCVQKNAEGLNQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC
>Mature Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGYAFELRTKVAEHLGVKAEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCEEEHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLEQVDEKTKIVWICNPNNPTGTYVEKQKLLSFLESV
HHHCCCCHHEEEHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAEAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAIGDAKL
CCCEEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQDCVQKNAEGLNQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]