BacMap

Definition	Bacillus cereus B4264, complete genome.
Accession	NC_011725
Length	5,419,036

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The map label for this gene is fabG [H]

Identifier: 218235728

GI number: 218235728

Start: 3800653

End: 3801366

Strand: Reverse

Name: fabG [H]

Synonym: BCB4264_A3884

Alternate gene names: 218235728

Gene position: 3801366-3800653 (Counterclockwise)

Preceding gene: 218235990

Following gene: 218235155

Centisome position: 70.15

GC content: 38.1

Gene sequence:

>714_bases
ATGAAAAAGTATGCGTTAGTAACTGGAGGGAGCGGAGGAATTGGCTCTGCTATTTCGAAACAATTAATTCAAGATGGATA
TACAGTTTATGTTCATTACAATAACAGTGAAGAAAAGGTATTGGAATTGCAGAAGGCATGGGGAGAAGTTATCCCTGTTC
AAGCGAATTTAGCTTCTAGTGATGGAGCAGGGCAATTGTGGGGACAAATTGAACATCCTATTGATGTTATTGTATACGCA
GCTGGGAAGAGTATTTTTGGACTAGTAACAGATGTAACAAACGATGAATTGGATTATATGGTAGAACTTCAAGTGAAGAA
CGTATATAAATTACTTTCTATGGCACTTCCGCCTATGATCGGGAGAAGAAGTGGTAATATTGTAATTGTTTCATCTATAT
GGGGACAAATAGGGGCTTCTTGTGAAGTGCTTTATTCAATGGTAAAAGGGGCACAAAATTCATATGTGAAAGCTTTAGCG
AAAGAAGTTTCTTTAAGTGGATTACGTGTGAATGCAGTAGCACCAGGAGCAATTGAAACGGAAATGTTAAGTGTTTTTTC
TGAAGAAGATAAAATGGGAATTGCTGAAGATATACCATTAGGTAGAATAGGATTACCAGAAGAAGTAGCGAAAACAGTTT
CATTCCTCGTATCACCAGGAGCGTCTTACATAACTGGACAAATTATCGGAGTGAATGGCGGTTGGCACTGCTAA

Upstream 100 bases:

>100_bases
AATTAAAAAGATACCCTCATCTTATCATTGAAAAATTGTAAGATGAGGGTATTATTTAGTTATGTGAAAATTGAACTTGT
AGAGATAAGAGAGGGACTTT

Downstream 100 bases:

>100_bases
AAAATTCTTACATAAAAAATGAATAGTTGCACAAATTAAGGATGATTTTATTACTCAATAGTGAGGTGCTTAATTATGTC
AGTATTAGATAATTTTGATC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKKYALVTGGSGGIGSAISKQLIQDGYTVYVHYNNSEEKVLELQKAWGEVIPVQANLASSDGAGQLWGQIEHPIDVIVYA
AGKSIFGLVTDVTNDELDYMVELQVKNVYKLLSMALPPMIGRRSGNIVIVSSIWGQIGASCEVLYSMVKGAQNSYVKALA
KEVSLSGLRVNAVAPGAIETEMLSVFSEEDKMGIAEDIPLGRIGLPEEVAKTVSFLVSPGASYITGQIIGVNGGWHC

Sequences:

>Translated_237_residues
MKKYALVTGGSGGIGSAISKQLIQDGYTVYVHYNNSEEKVLELQKAWGEVIPVQANLASSDGAGQLWGQIEHPIDVIVYA
AGKSIFGLVTDVTNDELDYMVELQVKNVYKLLSMALPPMIGRRSGNIVIVSSIWGQIGASCEVLYSMVKGAQNSYVKALA
KEVSLSGLRVNAVAPGAIETEMLSVFSEEDKMGIAEDIPLGRIGLPEEVAKTVSFLVSPGASYITGQIIGVNGGWHC
>Mature_237_residues
MKKYALVTGGSGGIGSAISKQLIQDGYTVYVHYNNSEEKVLELQKAWGEVIPVQANLASSDGAGQLWGQIEHPIDVIVYA
AGKSIFGLVTDVTNDELDYMVELQVKNVYKLLSMALPPMIGRRSGNIVIVSSIWGQIGASCEVLYSMVKGAQNSYVKALA
KEVSLSGLRVNAVAPGAIETEMLSVFSEEDKMGIAEDIPLGRIGLPEEVAKTVSFLVSPGASYITGQIIGVNGGWHC

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=32.6359832635983, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=33.6099585062241, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI5031737, Length=240, Percent_Identity=32.5, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=30.4878048780488, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI66933014, Length=207, Percent_Identity=28.5024154589372, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=29.0196078431373, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=28.0334728033473, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI59889578, Length=168, Percent_Identity=34.5238095238095, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=27.4193548387097, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=23.8866396761134, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=31.7991631799163, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=31.7073170731707, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=34.0163934426229, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=28.1632653061224, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367365, Length=234, Percent_Identity=27.3504273504274, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1790717, Length=240, Percent_Identity=24.1666666666667, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=28.4552845528455, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=28.8, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=26.4367816091954, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=34.5238095238095, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=245, Percent_Identity=28.9795918367347, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=31.0077519379845, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=31.496062992126, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=28.75, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=32.0610687022901, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=32.3420074349442, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.5343511450382, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=256, Percent_Identity=29.6875, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=259, Percent_Identity=30.1158301158301, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=30.1526717557252, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=245, Percent_Identity=26.530612244898, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=30.5343511450382, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=28.4615384615385, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=29.6992481203008, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=29.0697674418605, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=27.3764258555133, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=257, Percent_Identity=27.2373540856031, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=272, Percent_Identity=25, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=31.1787072243346, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=118, Percent_Identity=33.8983050847458, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=29.3233082706767, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=30.0380228136882, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=241, Percent_Identity=24.0663900414938, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=26.6129032258064, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=33.8842975206612, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=29.8755186721992, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=32.5396825396825, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=30.4526748971193, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.3492063492063, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=27.843137254902, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24643142, Length=237, Percent_Identity=29.957805907173, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=39.1666666666667, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 25266; Mature: 25266

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYALVTGGSGGIGSAISKQLIQDGYTVYVHYNNSEEKVLELQKAWGEVIPVQANLASS
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCC
DGAGQLWGQIEHPIDVIVYAAGKSIFGLVTDVTNDELDYMVELQVKNVYKLLSMALPPMI
CCCHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
GRRSGNIVIVSSIWGQIGASCEVLYSMVKGAQNSYVKALAKEVSLSGLRVNAVAPGAIET
CCCCCCEEEEECHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHHH
EMLSVFSEEDKMGIAEDIPLGRIGLPEEVAKTVSFLVSPGASYITGQIIGVNGGWHC
HHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MKKYALVTGGSGGIGSAISKQLIQDGYTVYVHYNNSEEKVLELQKAWGEVIPVQANLASS
CCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCC
DGAGQLWGQIEHPIDVIVYAAGKSIFGLVTDVTNDELDYMVELQVKNVYKLLSMALPPMI
CCCHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
GRRSGNIVIVSSIWGQIGASCEVLYSMVKGAQNSYVKALAKEVSLSGLRVNAVAPGAIET
CCCCCCEEEEECHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHHH
EMLSVFSEEDKMGIAEDIPLGRIGLPEEVAKTVSFLVSPGASYITGQIIGVNGGWHC
HHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]