Click here to switch to the map view.

The map label for this gene is pyn1 [H]

Identifier: 218235587

GI number: 218235587

Start: 1805596

End: 1806891

Strand: Direct

Name: pyn1 [H]

Synonym: BCB4264_A1897

Alternate gene names: 218235587

Gene position: 1805596-1806891 (Clockwise)

Preceding gene: 218234974

Following gene: 218231414

Centisome position: 33.32

GC content: 37.19

Gene sequence:

>1296_bases
ATGGTAGATATTATTGCAAAAAAACGTGACGGCAAAGAATTAACGACTGAAGAAATCAAATTCTTTATTAATGGATATAC
AGACGGAAGTATTCCTGATTATCAAGTGAGTGCGCTTGCAATGGCAATCTTCTTTAAAGATATGACAGATCGCGAACGTG
CAGATTTAACGATGGCGATGGTTGAGTCTGGAGAAACGATCGACTTATCAGCAATTGAAGGAATTAAAGTAGACAAACAT
TCAACTGGCGGTGTTGGTGATACAACAACATTAGTATTAGGACCATTAGTAGCTGCTTTAGATGTACCAGTAGCAAAAAT
GTCTGGTCGTGGTTTAGGACATACGGGCGGAACAATTGATAAATTAGAAGCGGTAGAAGGATTCCACGTTGAAATTACGA
AAGAGCAGTTCATTGATATTGTAAACCGTGACAAAGTAGCTGTTATTGGACAAACAGGAAACTTAACACCTGCAGATAAA
AAAATCTATGCATTACGCGATGTAACCGGAACGGTTAACTCAATTCCTTTAATCGCAAGTTCAATTATGAGTAAAAAAAT
TGCAGCTGGTGCTGACGCAATCGTACTTGATGTAAAAACAGGTGCTGGCGCATTTATGAAAACAGAAGAAGATGCAAAAG
AATTAGCACATGCAATGGTACGTATCGGAAATAATGTAGGACGTCAAACTATGGCTGTTATTTCAGATATGTCACAACCT
CTTGGATTTGCGATTGGTAATGCTCTAGAAGTGAAAGAAGCGATTGATACGTTAAAAGGTGAAGGTCCAGAAGATTTAAC
AGAATTAGTACTTGTATTAGGAAGTCAAATGGTTGTACTTGCGAAAAAAGCAAATACGTTAGAAGAAGCTCGTGAAATGC
TAATTGAAGTGATGAAAAACGGAAAAGCAATTGAGAAATTTAAAGAGTTCTTAAGTAATCAAGGCGGAGATAGCTCAATT
GTAGACAATCCAGAAAAAATGCCACAAGCTAAGTATGTAATTGATGTACCTGCAAAAACTTCAGGTGTTATTTCTAACAT
TGTTGCAGATGAGATTGGTATTGCAGCTATGTTACTTGGTGCAGGTCGTGCAACGAAGGAAGATGAAATCGATTTAGCGG
TAGGTTTAATGTTACGTAAAAAAGTTGGCGATGCAGTAAAAGAAGGCGAGCCATTCGTAACAATCTACGCAAATCGTGAA
AATGTAGAAGATGTAAAAGCAAAAATTTATGAAAACATCTCTATCGCTGAAACAGCAGTGGCTCCTAAATTAGTTCATAC
AGTTATTACTGACTAA

Upstream 100 bases:

>100_bases
ATTCGGTGCAACATTAGTAAGTTTCTTATCAGCAACAATCGTTGGCTTACTATTTTAATAGATTCATATAATATAAAAAG
GAATGGTGATTGTAATGAGA

Downstream 100 bases:

>100_bases
TCATCATTTCATTTACTTTGAGGGGGAAATAATATGGATAAGAAAAAATATATTGAAGAAGCAAACAAGATGTTATCGAA
AGCGTATATTCCGTATTCTA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVDKH
STGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADK
KIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMSQP
LGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKAIEKFKEFLSNQGGDSSI
VDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRE
NVEDVKAKIYENISIAETAVAPKLVHTVITD

Sequences:

>Translated_431_residues
MVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVDKH
STGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADK
KIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMSQP
LGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKAIEKFKEFLSNQGGDSSI
VDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRE
NVEDVKAKIYENISIAETAVAPKLVHTVITD
>Mature_431_residues
MVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVDKH
STGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADK
KIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMSQP
LGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKAIEKFKEFLSNQGGDSSI
VDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRE
NVEDVKAKIYENISIAETAVAPKLVHTVITD

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=422, Percent_Identity=35.5450236966825, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI4503445, Length=422, Percent_Identity=35.5450236966825, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI166158922, Length=422, Percent_Identity=35.5450236966825, Blast_Score=270, Evalue=3e-72,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=46.7821782178218, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46020; Mature: 46020

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAM
CCCCEECCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEHEE
VESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTID
CCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHH
KLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLIAS
HHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHH
SIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMSQP
HHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
LGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKN
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHC
GKAIEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLG
CHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAETAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHH
APKLVHTVITD
HHHHHHHHHCC
>Mature Secondary Structure
MVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAM
CCCCEECCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEHEE
VESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTID
CCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHH
KLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLIAS
HHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHH
SIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMSQP
HHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
LGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKN
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHC
GKAIEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLG
CHHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAETAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHH
APKLVHTVITD
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]