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The map label for this gene is nupC [H]

Identifier: 218234974

GI number: 218234974

Start: 1804372

End: 1805553

Strand: Direct

Name: nupC [H]

Synonym: BCB4264_A1896

Alternate gene names: 218234974

Gene position: 1804372-1805553 (Clockwise)

Preceding gene: 218232917

Following gene: 218235587

Centisome position: 33.3

GC content: 33.59

Gene sequence:

>1182_bases
ATGAAATACTTAATCGGTGTTTTTGGCCTCGTATTGATTTTAGGTATCGCTTGGCTTGCTAGTAATGATAGGAAGAAAGT
CAAATATCGCCCAATCATAACGATGGTTATATTACAATTCATTTTGGGGTTTCTATTATTAAATACAAGTGTAGGGAATA
TATTAATAAGCGGAATAGCAGATGGTTTTGGAGAGTTATTAAAATATGCCGCTGACGGTGTGAATTTCGTATTTGGTGGA
TTAGTAAATCAAAAAGAGTTTTCGTTCTTTTTAAGTGTATTAATGCCAATCGTATTTATATCAGCCTTAATAGGTATTTT
GCAACATATTAAAGTATTACCTATTATTGTGAAATCTATCGGTCTAGCATTAAGTAAAGTAAATGGAATGGGGAAACTAG
AATCATATAACGCTGTGGCATCAGCGATTTTAGGACAATCGGAAGTATTTATTTCAGTTAAGAAACAACTAGGGTTATTG
CCAGAGAAAAGAATGTATACATTATGTGCATCAGCAATGTCTACAGTTTCTATGTCTATCGTTGGATCATATATGGTGTT
ATTAAAACCACAATATGTTGTAACCGCTTTAGTGCTTAACTTATTCGGTGGCTTCATCATTGCTTCTATCATTAACCCGT
ATGAAGTTACTGAGGAAGAAGATATGTTAGAAGTACAAGAAGAAGAGAAAAAGACTTTCTTTGAAGTATTAGGGGAATAC
ATTATTGATGGATTTAAAGTTGCGATTACAGTAGCAGCTATGTTAGTCGGTTTCGTTGCTCTTATCGCATTCATTAATGC
AGTATTTAAAGGTGTAATCGGTATTTCATTCCAAGAAATTCTTGGTTATGCATTTGCACCATTTGCATTTATTATGGGTG
TACCTTGGCATGAAGCAGTTAATGCCGGAAATATTATGGCAACAAAATTAGTATCAAATGAATTTGTCGCTATGACAGAT
TTAGCACAAGGAAACTTTAATTTCTCAGATAGAACGACAGCGATTATCTCTGTATTCTTAGTTTCATTTGCAAACTTCTC
TTCAATTGGGATTATTGCAGGAGCAGTTAAGAGTTTAAATGAAAAGCAAGGGAATGTAGTCGCAAGATTTGGTTTGAAAT
TACTATTCGGTGCAACATTAGTAAGTTTCTTATCAGCAACAATCGTTGGCTTACTATTTTAA

Upstream 100 bases:

>100_bases
ATCGATAAAAGATTAAAGCAATAGATATACATTTAAAGTATATCTATTGCTTTAATAATTGAAAAAAATGTAAGCGGATA
CGAATGGGAGGAAACGGCTT

Downstream 100 bases:

>100_bases
TAGATTCATATAATATAAAAAGGAATGGTGATTGTAATGAGAATGGTAGATATTATTGCAAAAAAACGTGACGGCAAAGA
ATTAACGACTGAAGAAATCA

Product: nucleoside transporter NupC

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKYLIGVFGLVLILGIAWLASNDRKKVKYRPIITMVILQFILGFLLLNTSVGNILISGIADGFGELLKYAADGVNFVFGG
LVNQKEFSFFLSVLMPIVFISALIGILQHIKVLPIIVKSIGLALSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLL
PEKRMYTLCASAMSTVSMSIVGSYMVLLKPQYVVTALVLNLFGGFIIASIINPYEVTEEEDMLEVQEEEKKTFFEVLGEY
IIDGFKVAITVAAMLVGFVALIAFINAVFKGVIGISFQEILGYAFAPFAFIMGVPWHEAVNAGNIMATKLVSNEFVAMTD
LAQGNFNFSDRTTAIISVFLVSFANFSSIGIIAGAVKSLNEKQGNVVARFGLKLLFGATLVSFLSATIVGLLF

Sequences:

>Translated_393_residues
MKYLIGVFGLVLILGIAWLASNDRKKVKYRPIITMVILQFILGFLLLNTSVGNILISGIADGFGELLKYAADGVNFVFGG
LVNQKEFSFFLSVLMPIVFISALIGILQHIKVLPIIVKSIGLALSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLL
PEKRMYTLCASAMSTVSMSIVGSYMVLLKPQYVVTALVLNLFGGFIIASIINPYEVTEEEDMLEVQEEEKKTFFEVLGEY
IIDGFKVAITVAAMLVGFVALIAFINAVFKGVIGISFQEILGYAFAPFAFIMGVPWHEAVNAGNIMATKLVSNEFVAMTD
LAQGNFNFSDRTTAIISVFLVSFANFSSIGIIAGAVKSLNEKQGNVVARFGLKLLFGATLVSFLSATIVGLLF
>Mature_393_residues
MKYLIGVFGLVLILGIAWLASNDRKKVKYRPIITMVILQFILGFLLLNTSVGNILISGIADGFGELLKYAADGVNFVFGG
LVNQKEFSFFLSVLMPIVFISALIGILQHIKVLPIIVKSIGLALSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLL
PEKRMYTLCASAMSTVSMSIVGSYMVLLKPQYVVTALVLNLFGGFIIASIINPYEVTEEEDMLEVQEEEKKTFFEVLGEY
IIDGFKVAITVAAMLVGFVALIAFINAVFKGVIGISFQEILGYAFAPFAFIMGVPWHEAVNAGNIMATKLVSNEFVAMTD
LAQGNFNFSDRTTAIISVFLVSFANFSSIGIIAGAVKSLNEKQGNVVARFGLKLLFGATLVSFLSATIVGLLF

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=418, Percent_Identity=25.3588516746411, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI227116277, Length=418, Percent_Identity=24.4019138755981, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI11545853, Length=416, Percent_Identity=25, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1788737, Length=392, Percent_Identity=59.4387755102041, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1788485, Length=412, Percent_Identity=33.495145631068, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1788488, Length=420, Percent_Identity=31.9047619047619, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560276, Length=391, Percent_Identity=25.5754475703325, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71991794, Length=405, Percent_Identity=24.6913580246914, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45552519, Length=386, Percent_Identity=26.6839378238342, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45552517, Length=386, Percent_Identity=26.6839378238342, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI19921868, Length=386, Percent_Identity=26.6839378238342, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI281360430, Length=399, Percent_Identity=24.5614035087719, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42507; Mature: 42507

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLIGVFGLVLILGIAWLASNDRKKVKYRPIITMVILQFILGFLLLNTSVGNILISGIA
CHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DGFGELLKYAADGVNFVFGGLVNQKEFSFFLSVLMPIVFISALIGILQHIKVLPIIVKSI
HHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLLPEKRMYTLCASAMSTVSMSI
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGSYMVLLKPQYVVTALVLNLFGGFIIASIINPYEVTEEEDMLEVQEEEKKTFFEVLGEY
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
IIDGFKVAITVAAMLVGFVALIAFINAVFKGVIGISFQEILGYAFAPFAFIMGVPWHEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHC
NAGNIMATKLVSNEFVAMTDLAQGNFNFSDRTTAIISVFLVSFANFSSIGIIAGAVKSLN
CCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EKQGNVVARFGLKLLFGATLVSFLSATIVGLLF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYLIGVFGLVLILGIAWLASNDRKKVKYRPIITMVILQFILGFLLLNTSVGNILISGIA
CHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DGFGELLKYAADGVNFVFGGLVNQKEFSFFLSVLMPIVFISALIGILQHIKVLPIIVKSI
HHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLLPEKRMYTLCASAMSTVSMSI
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGSYMVLLKPQYVVTALVLNLFGGFIIASIINPYEVTEEEDMLEVQEEEKKTFFEVLGEY
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
IIDGFKVAITVAAMLVGFVALIAFINAVFKGVIGISFQEILGYAFAPFAFIMGVPWHEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHC
NAGNIMATKLVSNEFVAMTDLAQGNFNFSDRTTAIISVFLVSFANFSSIGIIAGAVKSLN
CCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EKQGNVVARFGLKLLFGATLVSFLSATIVGLLF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]