Click here to switch to the map view.

The map label for this gene is clpP1 [H]

Identifier: 218233818

GI number: 218233818

Start: 2694183

End: 2694764

Strand: Reverse

Name: clpP1 [H]

Synonym: BCB4264_A2798

Alternate gene names: 218233818

Gene position: 2694764-2694183 (Counterclockwise)

Preceding gene: 218234396

Following gene: 218234904

Centisome position: 49.73

GC content: 35.4

Gene sequence:

>582_bases
ATGAATACAATTCCATATGTAGTAGAACAAACAAAATTAGGAGAACGTTCCTATGATATATATTCAAGGTTATTAAAAGA
CCGCATTATTATTATCGGCTCAGAAATTAACGATCAAGTAGCGAGTAGTGTCGTAGCGCAATTATTATTTTTAGAAGCAG
AAGATGCAGAAAAAGATATATATTTATACATCAATAGCCCAGGAGGTTCAACGACAGCAGGTTTTGCAATATTAGATACG
ATGAATTTAATTAAACCAGATGTGCAAACGCTATGCATGGGCTTTGCGGCATCATTCGGTGCATTGTTATTATTATCAGG
AGCAAAAGGAAAACGGTTTGCGCTCCCTAACAGTGAAATTATGATTCATCAGCCGCTTGGTGGTGCACAAGGGCAAGCAA
CAGAAATTGAAATAACTGCGAAAAGAATATTAAAGTTAAAGCATGATATTAATAAAATGATTGCAGAAAAAACAGGCCAA
CCGATTGAAAGAGTAGCACATGATACAGAAAGAGATTATTTTATGACTGCAGAAGAAGCGAAGGCATATGGGATTGTAGA
TGACGTTGTTACGAAAAAATAA

Upstream 100 bases:

>100_bases
GTTACCATCTAAACAGCCAGTGTTATTATTTAATGTGAAAAACCCTTCTTCCTACAGTTGTATGCTTTGCGTAGCATAAC
AAGTATTGGAGGAATTTAAA

Downstream 100 bases:

>100_bases
GATGAAAAAGGCTAGAGGATATATTAATTCTCTAGCCTTTTTATTAATCCTTTACCCATTCATCAACTAATGCTTGATTT
TTTTTAATCCATTTTCGCGC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNTIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIYLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Sequences:

>Translated_193_residues
MNTIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIYLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK
>Mature_193_residues
MNTIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIYLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=54.0106951871658, Blast_Score=205, Evalue=2e-53,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=61.6580310880829, Blast_Score=257, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=48.9473684210526, Blast_Score=199, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=55.2631578947368, Blast_Score=219, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21239; Mature: 21239

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCEEEHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCEEECCCCCE
MIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC
>Mature Secondary Structure
MNTIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCEEEHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCEEECCCCCE
MIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]