Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 218233674

GI number: 218233674

Start: 20344

End: 21618

Strand: Direct

Name: serS [H]

Synonym: BCB4264_A0016

Alternate gene names: 218233674

Gene position: 20344-21618 (Clockwise)

Preceding gene: 218234434

Following gene: 218230771

Centisome position: 0.38

GC content: 37.25

Gene sequence:

>1275_bases
ATGCTTGATATTAAATTTTTACGTACAAACTTTGAAGAAGTAAAAGCGAAATTACAGCATAGAGGCGAAGATTTAACTGA
TTTCGGACGTTTTGAAGAATTGGATACGAGAAGAAGAGAACTACTTGTTCAGACAGAAGAATTAAAAAGTAAACGTAACG
AAGTATCTCAACAAATTTCTGTATTAAAGCGCGAAAAGAAAGATGCAGAAGCTCTAATTTTAGAAATGCGTGAAGTTGGA
GAAAAAGTAAAGGATCTTGATAACGAACTTCGTACAGTTGAAGAAGACTTAGAAAGATTAATGTTATCTATTCCAAATAT
CCCTCATGAATCTGCTCCAGTTGGTGAAACAGAGGATGATAATGTAGTAGCACGTACTTGGGGAGAAGTGAAAGAATTTA
CTTATGAGCCAAAACCACATTGGGATCTTGCTACTGATTTAGGAATTTTAGATTTTGAACGCGCTGGGAAAGTAACTGGA
AGCCGCTTCGTATTTTACAAAGGTGCTGGTGCAAGATTAGAGCGTGCTTTAATTAGCTTTATGCTTGATCTTCATACTGA
TGAGCATGGATATGAAGAAGTATTACCTCCATATATGGTAAACCGTGCAAGTATGACAGGAACAGGACAACTTCCAAAGT
TTGAAGAAGATGCATTCCGTATTGAAAGTGAAGATTACTTCTTAATTCCAACAGCTGAAGTACCTGTAACGAATATGCAT
CGTGATGAGATTTTAAATAAAGAGCAATTGCCTATAAGATATGCTGCATTTAGCTCTTGCTTCCGTTCTGAAGCAGGTTC
AGCTGGGCGTGACACACGTGGTTTAATTCGCCAGCATCAGTTCAATAAAGTAGAGCTTGTGAAGTTCGTAAAACCAGAAG
ATTCTTATGAAGAGTTAGAAAAGTTAACAAATGATGCAGAACGCGTGTTACAATTATTAGAGTTGCCATATCGCGTTATG
AGTATGTGCACAGGCGATTTAGGATTTACAGCAGCGAAGAAATACGATATTGAAGTATGGATTCCAAGCTATGGCACATA
TCGTGAAATTTCTTCTTGTAGTAATTTTGAAGCTTTCCAAGCGAGACGTGCAAATATCCGTTTCCGCCGTGAACCAAATG
GAAAACCAGAACATGTTCATACATTAAATGGATCTGGTCTTGCAATTGGACGTACGGTTGCAGCTATTTTAGAGAACTAC
CAACAAGAAGATGGTACAATTATAATTCCAGAAGTTCTTCGCCCTTATATGGGAGGAAAAACAGTTATTAAGTAA

Upstream 100 bases:

>100_bases
GTAATGCTTTCAACTAGGGTGGCAACGCGGGTTAACTCCCGTCCCTTTATATAGGGACGGGAGTTTTTTGTGTTTTATAA
AATAAAAGGAGGAGTATATA

Downstream 100 bases:

>100_bases
ATTTAAACATTCATCGGTATGAGTGATTGGTAATTATGAGCGTTGTCAGTACTGTAATGTAGGAAGGGGAAAGTAAAATT
TTCCTTTCCTCATAATTTAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFTYEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Sequences:

>Translated_424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFTYEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK
>Mature_424_residues
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQISVLKREKKDAEALILEMREVG
EKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDDNVVARTWGEVKEFTYEPKPHWDLATDLGILDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=330, Percent_Identity=39.6969696969697, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI8923421, Length=396, Percent_Identity=30.5555555555556, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=334, Percent_Identity=32.9341317365269, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=51.8779342723005, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=31.317494600432, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=354, Percent_Identity=30.225988700565, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=392, Percent_Identity=36.2244897959184, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6321799, Length=398, Percent_Identity=32.6633165829146, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24581334, Length=333, Percent_Identity=38.7387387387387, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17737985, Length=299, Percent_Identity=35.7859531772575, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48791; Mature: 48791

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAEALILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVARTWGEVKEFTYEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISF
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEEEECCCCCCCCCC
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC
>Mature Secondary Structure
MLDIKFLRTNFEEVKAKLQHRGEDLTDFGRFEELDTRRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKREKKDAEALILEMREVGEKVKDLDNELRTVEEDLERLMLSIPNIPHESAPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVARTWGEVKEFTYEPKPHWDLATDLGILDFERAGKVTGSRFVFYKGAGARLERALISF
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTDEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFRIESEDYFLIPTAEVPVTNMH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCHHEEECCCCEEEEECCCCCCCCCC
RDEILNKEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELE
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSYGTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCHHHHH
ARRANIRFRREPNGKPEHVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA