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The map label for this gene is hemY1 [H]

Identifier: 218233560

GI number: 218233560

Start: 1080363

End: 1081784

Strand: Direct

Name: hemY1 [H]

Synonym: BCB4264_A1105

Alternate gene names: 218233560

Gene position: 1080363-1081784 (Clockwise)

Preceding gene: 218234382

Following gene: 218235001

Centisome position: 19.94

GC content: 41.14

Gene sequence:

>1422_bases
TTGAGGAAAAAAGTTGTGATCGTCGGCGGAGGCATCACTGGATTAACAGCAATGTATAACTTACAAAAAAATATTCATGA
AAAAAACTTGCCGATTGATACATTACTTATAGAAGCATCGGGTAAACTTGGCGGAAAAATTCAAACCGTTCGAAAAGATG
GATTTACAATTGAGCGCGGACCAGATTCTTTCTTAGCACGAAAAGAAAGTGCAGCTAGATTAGTGAAAGAATTAGGTCTT
GGCGATGAACTTGTAAATAATCAAGCCGGTCAATCATTTATCCTTGTAAACAATCGGTTACATAAAATGCCGAATGGATC
AATGATGGGAATTCCAACGCAAATTACGCCGTTTCTATTTTCCGGGCTGTTCTCCCCAATTGGTAAACTAAGAGCTGGCT
TTGATCTATTAATGCCGAGGTCAAAGCCAGTATCTGACCAATCACTCGGACAATTTTTCAGACATCGTCTTGGAAACGAA
GTGGTTGAAAACTTAATAGAGCCGTTACTATCGGGTATTTATGCAGGGGATATTGATGAAATGAGCTTAATGTCAACATT
CCCGCAAATGTATCAAATTGAGCAGAAACATCGCAGTATTTCACTCGGTATGCGTACGCTCGCTCCGAAAGAAGAGAAAG
CTGAACCGAAAAAGGGAATGTTCCAAACAGTGAAAACAGGTTTAGAATCTATCGTAAAATCTCTCGAAGCAAAGATGCAT
GAAGGTACGATAATAAAGGGAACTCGCATTGAAAAAGTTGCGAAACAGGGTGATGGTTATACGATTACTCTTAGTAACGG
AAAAGAAATAGAAGCGGACGCCATCGTAGTGGCAACTTCGCATAAAGTATTGCCGTCCATGTTTGCTCAGTACAAGCAGT
TTCGTTTCTTCCGTAATATTCCATCCACATCCGTTGCGAATGTGGCACTTGCTTTCCAAAAGTCTGCAATCCAGCGCGAT
ATTAATGGTACAGGATTTGTCGTATCACGAAATAGCGATTACACCATTACAGCATGTACGTGGACGCATAAAAAATGGCC
ACATACAACGCCAGAAGGAAAAACACTCCTTCGCTGTTACGTTGGACGTGCTGGTGATGAAGCGGTTGTAGAACAAACTG
AAGAAGAACTCGTTCAGCTCGTACTAGAAGATTTAAGGAAGACGATGGATATTACAGAGGATCCAGAGTTTACAATCGTA
AGTCGCTGGAAAGAAGCGATGCCTCAATATACAGTGGGCCATAACGAGCGAATGAAAAAGCTCACAACATTTATGGAGAA
AGAGTTGCCAGGTATATACTTGGCAGGTAGCTCCTATGCTGGTGCTGGACTTCCAGACTGTATGAATCAAGGTGAGGAAG
CTGCAAAGCGTGTATTATCTCATTTGGAGAAAGTAATAGATGCTGAATTAATCGCACAATAA

Upstream 100 bases:

>100_bases
CCAGAAATGCCAAATGCATCGGAGGCATTTATTGATTGTTTAACAGATGTTGTATTAAAGAAAAAAGAATCTGTACTGTA
AGAAGAAAGGAGGAGCCTGC

Downstream 100 bases:

>100_bases
ATTATAAGAAACGCCTTCAATCATATTGAAGGCGTTTCGTTTATTATATAAAATACTTATTCGCCAATAAACATATATAA
GTTATTTGGCTTTATAACAG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRKKVVIVGGGITGLTAMYNLQKNIHEKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPNGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGQFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKEEKAEPKKGMFQTVKTGLESIVKSLEAKMH
EGTIIKGTRIEKVAKQGDGYTITLSNGKEIEADAIVVATSHKVLPSMFAQYKQFRFFRNIPSTSVANVALAFQKSAIQRD
INGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRAGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTIV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGAGLPDCMNQGEEAAKRVLSHLEKVIDAELIAQ

Sequences:

>Translated_473_residues
MRKKVVIVGGGITGLTAMYNLQKNIHEKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPNGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGQFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKEEKAEPKKGMFQTVKTGLESIVKSLEAKMH
EGTIIKGTRIEKVAKQGDGYTITLSNGKEIEADAIVVATSHKVLPSMFAQYKQFRFFRNIPSTSVANVALAFQKSAIQRD
INGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRAGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTIV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGAGLPDCMNQGEEAAKRVLSHLEKVIDAELIAQ
>Mature_473_residues
MRKKVVIVGGGITGLTAMYNLQKNIHEKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPNGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGQFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKEEKAEPKKGMFQTVKTGLESIVKSLEAKMH
EGTIIKGTRIEKVAKQGDGYTITLSNGKEIEADAIVVATSHKVLPSMFAQYKQFRFFRNIPSTSVANVALAFQKSAIQRD
INGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRAGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTIV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGAGLPDCMNQGEEAAKRVLSHLEKVIDAELIAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=493, Percent_Identity=29.2089249492901, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4506001, Length=493, Percent_Identity=29.2089249492901, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52525; Mature: 52525

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKVVIVGGGITGLTAMYNLQKNIHEKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAARLVKELGLGDELVNNQAGQSFILVNNRLHKMPNGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCEECCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGQFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKEEKAEPKKGMFQTVKTGLESIVKSLEAKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGTIIKGTRIEKVAKQGDGYTITLSNGKEIEADAIVVATSHKVLPSMFAQYKQFRFFRNI
CCCEECCCHHHHHHHCCCCEEEEECCCCEECCCEEEEEECHHHHHHHHHHHHHHHHHHCC
PSTSVANVALAFQKSAIQRDINGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCY
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCHHHHHHH
VGRAGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTIVSRWKEAMPQYTVGHNERMKK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGAGLPDCMNQGEEAAKRVLSHLEKVIDAELIAQ
HHHHHHHCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKVVIVGGGITGLTAMYNLQKNIHEKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAARLVKELGLGDELVNNQAGQSFILVNNRLHKMPNGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCEECCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGQFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKEEKAEPKKGMFQTVKTGLESIVKSLEAKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGTIIKGTRIEKVAKQGDGYTITLSNGKEIEADAIVVATSHKVLPSMFAQYKQFRFFRNI
CCCEECCCHHHHHHHCCCCEEEEECCCCEECCCEEEEEECHHHHHHHHHHHHHHHHHHCC
PSTSVANVALAFQKSAIQRDINGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCY
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCHHHHHHH
VGRAGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTIVSRWKEAMPQYTVGHNERMKK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGAGLPDCMNQGEEAAKRVLSHLEKVIDAELIAQ
HHHHHHHCCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]