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The map label for this gene is hemH [H]

Identifier: 218234382

GI number: 218234382

Start: 1079408

End: 1080343

Strand: Direct

Name: hemH [H]

Synonym: BCB4264_A1104

Alternate gene names: 218234382

Gene position: 1079408-1080343 (Clockwise)

Preceding gene: 218233350

Following gene: 218233560

Centisome position: 19.92

GC content: 38.35

Gene sequence:

>936_bases
ATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAACGTTACTATACACA
TATTCGCAGAGGAAGAAAGCCAAGTCCTGAAATGCTGGAAGATTTAACAGAGCGTTACCGTGCAATTGGTGGTATTTCTC
CTTTAGCTACTATTACATTAGAGCAAGCTAAGAAGTTAGAGAAGCGTTTAAATGAAGTACAAGATGAAGTAGAGTACCAT
ATGTATCTTGGCTTAAAACATATTGAACCGTTTATTGAAGATGCGGTGAAAGATATGCATAACGACGGAATACAAGATGC
AATCGCACTTGTTCTTGCACCTCACTATTCTACGTTTAGCGTGAAATCGTACGTTGGACGAGCACAAGAAGAAGCTGAGA
AACTTGGAAACTTAACAATTCACGGCATTGATAGCTGGTATAAAGAGCCGAAATTCATCCAGTACTGGGTTGATGCAGTG
AAAGGTATATATAACGGTATGTCAGATGCAGAGCGTGAAAAAGCAGTATTAATCGTATCTGCACATAGCTTACCAGAGAA
AATTATTGCAATGGGGGATCCATATCCAGATCAATTAAATGAAACAGCGGATTATATCGCGCGCGGAGCTGAAGTAGCAA
ACTATGCAGTAGGCTGGCAAAGTGCAGGAAACACACCAGATCCTTGGATTGGTCCAGATGTACAAGATTTAACGAGAGAA
CTAAATGAAAAGCACGGTTATACTTCATTCGTATATGCACCGGTTGGATTTGTTGCGGAACATTTAGAAGTTTTATATGA
CAACGACTTTGAGTGTAAAGTTGTAACGGATGAAATTGGTGCAAAATATTATCGTCCAGAAATGCCAAATGCATCGGAGG
CATTTATTGATTGTTTAACAGATGTTGTATTAAAGAAAAAAGAATCTGTACTGTAA

Upstream 100 bases:

>100_bases
GTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAGTTAGCG
AAGTAAAGGAGCATTGCTGT

Downstream 100 bases:

>100_bases
GAAGAAAGGAGGAGCCTGCTTGAGGAAAAAAGTTGTGATCGTCGGCGGAGGCATCACTGGATTAACAGCAATGTATAACT
TACAAAAAAATATTCATGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASEAFIDCLTDVVLKKKESVL

Sequences:

>Translated_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASEAFIDCLTDVVLKKKESVL
>Mature_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASEAFIDCLTDVVLKKKESVL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=30.4832713754647, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=30.4832713754647, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324750, Length=282, Percent_Identity=26.9503546099291, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=25.6024096385542, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45552018, Length=174, Percent_Identity=31.6091954022989, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=22.5296442687747, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35316; Mature: 35316

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASEAFIDCLT
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCHHHHHHHHHH
DVVLKKKESVL
HHHHHHHHCCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKDMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKHGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASEAFIDCLT
HHHHCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCHHHHHHHHHH
DVVLKKKESVL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]