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The map label for this gene is panF [H]

Identifier: 218233481

GI number: 218233481

Start: 3575434

End: 3576867

Strand: Reverse

Name: panF [H]

Synonym: BCB4264_A3660

Alternate gene names: 218233481

Gene position: 3576867-3575434 (Counterclockwise)

Preceding gene: 218235398

Following gene: 218232861

Centisome position: 66.01

GC content: 36.47

Gene sequence:

>1434_bases
ATGAATTGGTATGTAATCATTCCAATGATAATTTCGTTTATCGTTGTATTTTTAATTGGTGTATATGCTTCAAGACGTGT
GCAAGCAACTGCTCATAATAAATTTTTACAAGAATATTTTCTTGGTGGGCGTGAGCTAGGCGGTTTATTATTAGCGATGA
CAATGATTGCTACGTACGGTAGTGCAAGTAGCTTTATTGGTGGCCCTGGTATTGCTTACAATATGGGGCTTGGATGGGTA
CTGTTATCTGCGATTCAAGTTGTAACAGGCTATATCGTTTTAACGGTTATCGGTAAAAAGTTTGCAATTATCGCTAGGAA
GATGGAAGCAATTACTCTTATCGATTATTTAAAAGGGAGATACAATAATAAAGCAGTTGTTATACTTTCTGCGTTATGTA
TTATTATCTTTTTATTTTCAGCGACAGTAGCCCAGTGGGTCGGTGGTGGACGATTAATCGAGTCACTAACGGGTCTATCG
TATACAACAGCACTATTTTTATTTACTTTTTCTGTACTTGTGTACGTATTAATTGGTGGATTTCGTGCAGTTGCTCTATC
AGATACATTATTAGGAATCATTATGTTAGTTGGAACGACAATCATTTTAATTGCTACTGTCATTGCTGGTGGTGGAATTG
AAAAGATTATGCAGGAACTTGTTCAAATTAATCCAAAGTTAATTACACCATTCGGAGCAGATGGCAGTTTAACGAAATCA
TATGTTACATCATTTTGGATTTTAATTGGAATTGGCGTTGTCGGCTTACCGCAAATTAGCGTGCGTGCCATGTCTTATAA
AAATTCAAAAGCGATGCATCAAGCTTTAATAATTGGAACCGTTGTCGTTGGCACAATTATGATCGGTATGCATTTAACTG
GTGTATTTGCAAGAGTAGTACTTCCAGGTATAACGGTACCAGATAAAGTAATGCCGCTACTTGCGATGGAAGTGTTACCT
CCTTGGTTAGCTGGAGTTTTCTTAGCTGCACCGATGGCAGCGATTATGTCTACAGTAAACTCTTTATTATTACTTGTAAG
CTCGTCAATTATTAAAGATATATACGTAAATTACATAAATAAAGATGCAGCAGACAGTACGATAAAAAAAGGAAGTTTAT
GGATTACTGGTATTGTAGGACTACTCGTTTATGCAGCGGCGATTAAACCACCAGATTTTTTAATATGGCTAAATTTATTT
TCTTTCGGTGGATTAGAAGCAGCATTCATTTGGCCAATCGTATTAGGGTTATATTGGAGGAAAGGAAATGCTACAGGAGC
GCTTGCGTCTATTTTAGTTGGGGTAGGCTCATATATGTGTATTCATCTTTTCTATCCAAATCCATTCGGTATACATACAG
TTGTCTTCCCGATTTGTTTTGCGTTTATCGCTTATGTTATTGGAAGTATGAGTGCTGTAAAAAAAACAGTATAG

Upstream 100 bases:

>100_bases
CGTTGGATTTATCGTTATGGTTATTTTACTTAGTTTAGTTGTTCGTTTTGTATTTCAAGATATTTCACTCGATGAGGAAG
AAAAAAGTGAGGAATAATAG

Downstream 100 bases:

>100_bases
GTTAGCTGAAGAACGTAGTCCTTATAAGACTGCGTTTTTTCTTATGAATTTGTTCTTTTTTTATTCTGTATATCCACGGT
TATTCATAAATTAATAACAA

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPKLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIKKGSLWITGIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVGSYMCIHLFYPNPFGIHTVVFPICFAFIAYVIGSMSAVKKTV

Sequences:

>Translated_477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPKLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIKKGSLWITGIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVGSYMCIHLFYPNPFGIHTVVFPICFAFIAYVIGSMSAVKKTV
>Mature_477_residues
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGRYNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTALFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPKLITPFGADGSLTKS
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGITVPDKVMPLLAMEVLP
PWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYINKDAADSTIKKGSLWITGIVGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNATGALASILVGVGSYMCIHLFYPNPFGIHTVVFPICFAFIAYVIGSMSAVKKTV

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=447, Percent_Identity=28.4116331096197, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4507035, Length=346, Percent_Identity=24.2774566473988, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI157671931, Length=365, Percent_Identity=21.3698630136986, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI14140236, Length=403, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082237, Length=470, Percent_Identity=48.2978723404255, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1787251, Length=444, Percent_Identity=27.7027027027027, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1790503, Length=456, Percent_Identity=25.219298245614, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790113, Length=473, Percent_Identity=24.3128964059197, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573698, Length=395, Percent_Identity=23.2911392405063, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51264; Mature: 51264

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPKLITPFGADGSLTKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGITVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIKKGSLWITGIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVGSYMCIHLFYPNPFGIHTVVFPICFAFIAYVIGSMSAVKKTV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCC
>Mature Secondary Structure
MNWYVIIPMIISFIVVFLIGVYASRRVQATAHNKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQVVTGYIVLTVIGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YNNKAVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTALFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIEKIMQELVQINPKLITPFGADGSLTKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGITVPDKVMPLLAMEVLPPWLAGVFLAAPMAAIMSTVNSLLLLVSSSIIKDIYVNYIN
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KDAADSTIKKGSLWITGIVGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KGNATGALASILVGVGSYMCIHLFYPNPFGIHTVVFPICFAFIAYVIGSMSAVKKTV
CCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]