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The map label for this gene is uppS [H]

Identifier: 218232974

GI number: 218232974

Start: 3843592

End: 3844365

Strand: Reverse

Name: uppS [H]

Synonym: BCB4264_A3921

Alternate gene names: 218232974

Gene position: 3844365-3843592 (Counterclockwise)

Preceding gene: 218234587

Following gene: 218230822

Centisome position: 70.94

GC content: 37.6

Gene sequence:

>774_bases
ATGTTTAAAAACTTTCCTTTTTTTAAAGGTAAAAAGGACACATCGTTTGATCATCTCGTTGAAGAAGTGAAAAAAGGATA
TATCCCAGAACATATTGCCATCATTATGGATGGGAATGGAAGATGGGCAAAGAGGAGAGCAATGCCTCGTATTGCGGGAC
ATCATGAAGGTATGCAAGTTGTAAAGAAAATTACAAAATTTGCAAGTAAACTTAATGTGAAAGTGTTAACTCTCTATGCT
TTTTCAACTGAGAACTGGAAAAGACCGAAAAAGGAAGTTGATTATTTAATGAAGCTTCCAGAAGAATTTCTAGGTACATT
TTTACCAGAATTGATTGAAGAAAACGTACAAGTCCGAGTAATAGGGCAAAAAGATCGTCTTCCTACGCATACACGCAGAG
CGATGGAGAAAGCCATGGAAGATACGAAAGAGAATACGGGATTAATTCTTAATTTCGCGTTAAACTATGGAAGTCGAGAT
GAAATCGTTTCTGCTGTGCAACATATGATGAAAGATAATGAGGAAGGAAAAATTCGTTCTGAAGAGGTAAGTGAAGAAAT
GCTTTCCTCCTACTTAATGACGAGTTCTTTACCTGATCCAGAGTTGTTAATCCGAACAAGCGGAGAGCTACGTATTAGTA
ATTTCATGTTATGGCAAATTGCATATTCGGAGTTTTGGTTTACAGACGTGTATTGGCCAGACTTCAAAGAAGAACATTTG
CTAAATGCGATTACTGACTTTCAACATAGAGGGCGCAGATTCGGAGGCGTGTAG

Upstream 100 bases:

>100_bases
ATGGAAGTGTAATAGCGATAACTTCGCAAATATGACCCTCTTCTTAAGGGGGTCTTTTTACACTTTTAGGCATACGTCTG
CTTGCTGGAGGGTATGAATG

Downstream 100 bases:

>100_bases
AAAGAGAGGGTTTGGTAGTGAAACAGAGAATTATTACTGGAGTGGTTGCTGCCGCGCTATTCATTCCCATCGTAATATAC
GGTGGCGTGCCTTTTACGGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLYA
FSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRD
EIVSAVQHMMKDNEEGKIRSEEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHL
LNAITDFQHRGRRFGGV

Sequences:

>Translated_257_residues
MFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLYA
FSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRD
EIVSAVQHMMKDNEEGKIRSEEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHL
LNAITDFQHRGRRFGGV
>Mature_257_residues
MFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLYA
FSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRD
EIVSAVQHMMKDNEEGKIRSEEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHL
LNAITDFQHRGRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=38.4279475982533, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=38.4279475982533, Blast_Score=164, Evalue=6e-41,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=44.9339207048458, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=34.9137931034483, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323748, Length=226, Percent_Identity=32.3008849557522, Blast_Score=121, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=31.924882629108, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=37.6106194690265, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30086; Mature: 30086

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHHH
VKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRV
HHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEE
IGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRDEIVSAVQHMMKDNEEGKIRS
ECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCH
EEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHL
HHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHEEHHHHHHEECCCCCCCCHHHH
LNAITDFQHRGRRFGGV
HHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHHH
VKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRV
HHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEE
IGQKDRLPTHTRRAMEKAMEDTKENTGLILNFALNYGSRDEIVSAVQHMMKDNEEGKIRS
ECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCH
EEVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFKEEHL
HHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHEEHHHHHHEECCCCCCCCHHHH
LNAITDFQHRGRRFGGV
HHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]