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The map label for this gene is ald1 [H]

Identifier: 218232919

GI number: 218232919

Start: 614007

End: 615140

Strand: Direct

Name: ald1 [H]

Synonym: BCB4264_A0630

Alternate gene names: 218232919

Gene position: 614007-615140 (Clockwise)

Preceding gene: 218234013

Following gene: 218232123

Centisome position: 11.33

GC content: 39.33

Gene sequence:

>1134_bases
ATGCGTATTGGGGTACCAGCAGAAATTAAAAACAACGAAAACCGTGTGGCAATGACACCAGCAGGTGTTGTACATTTAAT
TCGTAACAATCACGAAGTATTCATTCAAAAGGGTGCAGGTTTAGGGTCTGGTTTCACAGATGCTCAGTATGTTGAAGCGG
GAGCAAAAATTGTTGATACAGCTGAAGAAGCTTGGAATATGGAAATGGTTATGAAAGTTAAGGAACCAATTGAAAGCGAA
TACAAACACTTCAGTGAAGGCTTAATCTTGTTCACATACTTACACTTAGCTCCAGAGCCAGAATTAACAAAAGCTTTAAT
CGAGAAAAAAGTTGTTTCTATCGCATATGAAACAGTACAATTAGAAAACCGTTCATTACCATTACTTGCGCCTATGAGTG
AAGTAGCTGGTCGTATGGCTGCACAAATTGGTGCACAATTCCTTGAGAAAAACAAAGGCGGTAAAGGTATCTTACTTGCA
GGTGTTCCAGGGGTTAAACGTGGTAAAGTAACAATCATCGGTGGTGGACAAGCTGGTACAAATGCTGCTAAAATTGCAGT
TGGACTAGGTGCGGATGTAACAATCATCGACTTAAGTGCAGAACGTCTTCGTCAATTAGATGACATTTTCGGAAACCAAG
TAAAAACTTTAATGTCTAATCCTTACAATATTGCAGAAGCTGTTAAAGAGTCTGATCTTGTAATCGGTGCAGTATTAATC
CCAGGTGCAAAAGCTCCAAAACTTGTAACAGAAGGAATGATTAAATCAATGGAACCAGGTTCTGTTGTTGTAGATATCGC
GATTGACCAAGGTGGTATTTTCGAAACAACTGACCGTATTACAACTCATGATAACCCAACTTACGAAAAACACGGCGTTG
TTCATTATGCAGTTGCAAACATGCCAGGTGCGGTTCCACGTACATCAACTCTTGCATTAACAAACGTAACAGTACCATAT
GCAGTACAAATTGCTAACAAAGGCTACAAAGAAGCTTGCCTAGGTAACACTGCATTACTAAAAGGTATTAACACATTAGA
TGGCTATGTAACATTCGAAGCAGTTGCAGAAGCTCACGGTGTAGAGTACAAAGGTGCTAAAGAATTATTAGAAGCAGAAA
CAGTATCTTGCTAA

Upstream 100 bases:

>100_bases
TAACTTTTAAGTTATGCTAGAATAAGGACATAAGTTATTAATTATTACAAAAAGAAAAAAGAATCTCTTTTTTCTGTTAA
TTATAAGGGGGCATTTCATT

Downstream 100 bases:

>100_bases
TAGAAGCATTATACAAAACAAAATCGAACAATATATAAAACAACATGATAAGAGCTAAGAGTGAAGATCTCTTAGCTCTT
CTTGGCAAAAGGGGGCATAC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRIGVPAEIKNNENRVAMTPAGVVHLIRNNHEVFIQKGAGLGSGFTDAQYVEAGAKIVDTAEEAWNMEMVMKVKEPIESE
YKHFSEGLILFTYLHLAPEPELTKALIEKKVVSIAYETVQLENRSLPLLAPMSEVAGRMAAQIGAQFLEKNKGGKGILLA
GVPGVKRGKVTIIGGGQAGTNAAKIAVGLGADVTIIDLSAERLRQLDDIFGNQVKTLMSNPYNIAEAVKESDLVIGAVLI
PGAKAPKLVTEGMIKSMEPGSVVVDIAIDQGGIFETTDRITTHDNPTYEKHGVVHYAVANMPGAVPRTSTLALTNVTVPY
AVQIANKGYKEACLGNTALLKGINTLDGYVTFEAVAEAHGVEYKGAKELLEAETVSC

Sequences:

>Translated_377_residues
MRIGVPAEIKNNENRVAMTPAGVVHLIRNNHEVFIQKGAGLGSGFTDAQYVEAGAKIVDTAEEAWNMEMVMKVKEPIESE
YKHFSEGLILFTYLHLAPEPELTKALIEKKVVSIAYETVQLENRSLPLLAPMSEVAGRMAAQIGAQFLEKNKGGKGILLA
GVPGVKRGKVTIIGGGQAGTNAAKIAVGLGADVTIIDLSAERLRQLDDIFGNQVKTLMSNPYNIAEAVKESDLVIGAVLI
PGAKAPKLVTEGMIKSMEPGSVVVDIAIDQGGIFETTDRITTHDNPTYEKHGVVHYAVANMPGAVPRTSTLALTNVTVPY
AVQIANKGYKEACLGNTALLKGINTLDGYVTFEAVAEAHGVEYKGAKELLEAETVSC
>Mature_377_residues
MRIGVPAEIKNNENRVAMTPAGVVHLIRNNHEVFIQKGAGLGSGFTDAQYVEAGAKIVDTAEEAWNMEMVMKVKEPIESE
YKHFSEGLILFTYLHLAPEPELTKALIEKKVVSIAYETVQLENRSLPLLAPMSEVAGRMAAQIGAQFLEKNKGGKGILLA
GVPGVKRGKVTIIGGGQAGTNAAKIAVGLGADVTIIDLSAERLRQLDDIFGNQVKTLMSNPYNIAEAVKESDLVIGAVLI
PGAKAPKLVTEGMIKSMEPGSVVVDIAIDQGGIFETTDRITTHDNPTYEKHGVVHYAVANMPGAVPRTSTLALTNVTVPY
AVQIANKGYKEACLGNTALLKGINTLDGYVTFEAVAEAHGVEYKGAKELLEAETVSC

Specific function: This enzyme is a key factor in the assimilation of L- alanine as an energy source through the tricarboxylic acid cycle during sporulation [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=348, Percent_Identity=33.0459770114943, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI122939153, Length=348, Percent_Identity=33.0459770114943, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1787887, Length=334, Percent_Identity=33.8323353293413, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17550456, Length=338, Percent_Identity=31.6568047337278, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 40177; Mature: 40177

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVPAEIKNNENRVAMTPAGVVHLIRNNHEVFIQKGAGLGSGFTDAQYVEAGAKIVDT
CCCCCCCCCCCCCCEEEECCHHHEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCHHHHH
AEEAWNMEMVMKVKEPIESEYKHFSEGLILFTYLHLAPEPELTKALIEKKVVSIAYETVQ
HHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEE
LENRSLPLLAPMSEVAGRMAAQIGAQFLEKNKGGKGILLAGVPGVKRGKVTIIGGGQAGT
ECCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCC
NAAKIAVGLGADVTIIDLSAERLRQLDDIFGNQVKTLMSNPYNIAEAVKESDLVIGAVLI
CCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEE
PGAKAPKLVTEGMIKSMEPGSVVVDIAIDQGGIFETTDRITTHDNPTYEKHGVVHYAVAN
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCEECCCCCCCHHCCEEEEEECC
MPGAVPRTSTLALTNVTVPYAVQIANKGYKEACLGNTALLKGINTLDGYVTFEAVAEAHG
CCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHCCHHHCCHHHHHHHHHHCC
VEYKGAKELLEAETVSC
CCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRIGVPAEIKNNENRVAMTPAGVVHLIRNNHEVFIQKGAGLGSGFTDAQYVEAGAKIVDT
CCCCCCCCCCCCCCEEEECCHHHEEEEECCCEEEEEECCCCCCCCCCHHHHHHCCHHHHH
AEEAWNMEMVMKVKEPIESEYKHFSEGLILFTYLHLAPEPELTKALIEKKVVSIAYETVQ
HHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEE
LENRSLPLLAPMSEVAGRMAAQIGAQFLEKNKGGKGILLAGVPGVKRGKVTIIGGGQAGT
ECCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCC
NAAKIAVGLGADVTIIDLSAERLRQLDDIFGNQVKTLMSNPYNIAEAVKESDLVIGAVLI
CCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEE
PGAKAPKLVTEGMIKSMEPGSVVVDIAIDQGGIFETTDRITTHDNPTYEKHGVVHYAVAN
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCEECCCCCCCHHCCEEEEEECC
MPGAVPRTSTLALTNVTVPYAVQIANKGYKEACLGNTALLKGINTLDGYVTFEAVAEAHG
CCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHCCHHHCCHHHHHHHHHHCC
VEYKGAKELLEAETVSC
CCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2340274 [H]