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The map label for this gene is ndk [H]

Identifier: 218232884

GI number: 218232884

Start: 1499785

End: 1500231

Strand: Direct

Name: ndk [H]

Synonym: BCB4264_A1571

Alternate gene names: 218232884

Gene position: 1499785-1500231 (Clockwise)

Preceding gene: 218233341

Following gene: 218234211

Centisome position: 27.68

GC content: 38.48

Gene sequence:

>447_bases
ATGGAAAAAACATTTCTAATGGTAAAACCAGACGGTGTACAACGTGCCTTCATTGGGGAAATTGTAGCTCGTTTTGAGAA
AAAAGGCTTTCAATTAGTTGGTGCAAAATTAATGCAAGTCACTCCAGAAATTGCTGGACAACACTACGCTGAGCATAAGG
AAAAACCTTTCTTTGGTGAGTTAGTAGACTTTATTACATCTGGACCTGTATTCGCAATGGTATGGCAAGGTGAAGGTGTA
GTAGATACAGCTCGTAACATGATGGGGAAAACAAGACCACATGAAGCAGCTCCTGGAACAATTCGTGGAGATTTCGGTGT
AACTGTTGCGAAAAACATTATCCATGGTTCTGATTCTTTAGAAAGCGCAGAGCGCGAGATTGCTATTTTCTTTAAAGAAG
AAGAATTAGTTGACTACTCAAAATTAATGAATGAATGGATTTACTAA

Upstream 100 bases:

>100_bases
TCTCTCTATTTCAAAACTATTGCACAATTGTGATAAGGGTGATAATATGTGTGTGGGGATATACAATTACATACATAATT
CAGAAGTGGAGAGATTTTTT

Downstream 100 bases:

>100_bases
TTATTTTGAAATAATTTGTAAACGCTTTAATCACTGTGATAATAGTAAAAAGTGCAAGGAGAATAGGGGTATTCTTCTTG
CACTTTTTTTATTTTCAGTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHKEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIAIFFKEEELVDYSKLMNEWIY

Sequences:

>Translated_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHKEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIAIFFKEEELVDYSKLMNEWIY
>Mature_148_residues
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHKEKPFFGELVDFITSGPVFAMVWQGEGV
VDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIAIFFKEEELVDYSKLMNEWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=57.8231292517007, Blast_Score=189, Evalue=9e-49,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=56.0810810810811, Blast_Score=188, Evalue=1e-48,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=56.0810810810811, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=54.7297297297297, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=54.7297297297297, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=54.7297297297297, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=54.7297297297297, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=54.7297297297297, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=49.6402877697842, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=36.4963503649635, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=46.8085106382979, Blast_Score=137, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=51.3513513513513, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17507605, Length=85, Percent_Identity=42.3529411764706, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=53.7414965986395, Blast_Score=180, Evalue=7e-47,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=53.7414965986395, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=33.8235294117647, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16642; Mature: 16642

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHKEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHH
LVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCCCHH
ESAEREIAIFFKEEELVDYSKLMNEWIY
HHHCCEEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHKEKPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHH
LVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSL
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCCCHH
ESAEREIAIFFKEEELVDYSKLMNEWIY
HHHCCEEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]