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The map label for this gene is hblA [H]

Identifier: 218232691

GI number: 218232691

Start: 2996720

End: 2998120

Strand: Reverse

Name: hblA [H]

Synonym: BCB4264_A3123

Alternate gene names: 218232691

Gene position: 2998120-2996720 (Counterclockwise)

Preceding gene: 218231853

Following gene: 218233257

Centisome position: 55.33

GC content: 32.91

Gene sequence:

>1401_bases
ATGATGAAAAAAATCCCTCATAAACTACTCGCTGTATCAGCGTTTTTAACTATAACAACTACTTATGCAGTCATACCACT
AGAAACTTTTGCAATTGAAATTGAACAAACGAACACTGAAAATATGTCTCTTTCAGCAAATGAAGAACAGATGAAAAAAG
CTTTGCAAGATGCTGGTTTATTTGCAAAAGCTATGAATGAATATTCTTATTTGCTAATTAATAATCCAGATGTGAGTTTT
GAAGGAATAACTATTAATGGAAATGCAGATTTACCTAGTAAAATTGTACAAGATCAAAAGAATGCAAGAGCACATGCTGT
TACATGGAATACACAAGTAAAAAAACAGCTTTTTGATACATTGACAGGCATTATAGAATACGATACAAAATTTGAAAATT
ATTATGAAACATTAGTAGAGGCGATCAATACTGGAAATGGAGATACTTTAAAAAAAGGGATTACAGATTTACAGGGAGGA
ATTCAACAAAATCAAAAGTCTGCAAAAGCATTAAAAGAAGAATTAATTCAATTAAAAAATGCTATTGGAGAAGATGTTAG
AACATTTGGAAGTCATAAAGAGACATTGCAATCGATTTTAAAAAACCAAGGTGCTGATGTGGAGGCTGACCAAAAGCGTC
TAGAGGACCTTTTAGGACAAGTAAAATATCAGAAAGACATAGAATCTAAGGGCTTAGACATGGTGAAAATCCCATTTATT
CCAACCTTGATTGCTGGTGGCATAATGATAGGTGATGCAAGAGGTAAGTTAGGTTGGCTAGAACCTGAATTAGCAAAATT
GCGTCAGACTGTAGATTATAAAATAACATTGAATCGTGTAGTTGGAGTTGCATTTCATAATATTAGTGATATGCATAGTA
TGCTTGATAGTGCTATCACTGCTCTTACTTATATGTCTACGCAATGGGAGGATTTAGATTCTCAATATTCGGGTGTACTG
GGACATATTGATAAAGCTGATCAAAAAGCTGATCAAAATAAATATAAATTCTTAACCCCTAGCTTGAATGCAGCGAAAAA
CAGTTGGAAAACATTAAAAACAGATGTTGTCACTTTGCAAGAAGGGATAAAAATTGCAGAGAAAAAAGAACAGGATTTTT
TGAATCAGCTTCGTCCATCAAACGTTTTCTACTTTTATAAAAAAATTCATAACGCATACACTTTTGAAATAAAGACTGGA
ACAAATGCGCCAAATGCGTCTTATAAAGTTATGAATTTAACGAAAAACACTGTTCATAATATGTGGAGTGGAGGGGCTAA
TACTAACATGTGGGCTGATTGGCTTTCATTCAATCCAAATGATGAATTTGCGGTAGTAGCAGTAGTGGATGGTAAAGAAT
ATGTTGTGTATAAAGACAAAGTACAAAATATAATGAACTGA

Upstream 100 bases:

>100_bases
TCAAACGATACTGATAAAAGATGTAGAACTCATTTTGAAAGACATCGCTTTTTAATAAGATTAGAACTTGAAACCATACC
TTATATAGGAGGAATACGAA

Downstream 100 bases:

>100_bases
ATCTGAAAGTAACGAAGTAATTGGAGCTGGAGAATAAACTAGACACCAAGTTAATCGAAAAATCTCCTTATATCCTAGAA
TATTTTGCTCAAGAAAAAGT

Product: hemolysin BL binding component

Products: NA

Alternate protein names: Enterotoxin 40 kDa subunit [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MMKKIPHKLLAVSAFLTITTTYAVIPLETFAIEIEQTNTENMSLSANEEQMKKALQDAGLFAKAMNEYSYLLINNPDVSF
EGITINGNADLPSKIVQDQKNARAHAVTWNTQVKKQLFDTLTGIIEYDTKFENYYETLVEAINTGNGDTLKKGITDLQGG
IQQNQKSAKALKEELIQLKNAIGEDVRTFGSHKETLQSILKNQGADVEADQKRLEDLLGQVKYQKDIESKGLDMVKIPFI
PTLIAGGIMIGDARGKLGWLEPELAKLRQTVDYKITLNRVVGVAFHNISDMHSMLDSAITALTYMSTQWEDLDSQYSGVL
GHIDKADQKADQNKYKFLTPSLNAAKNSWKTLKTDVVTLQEGIKIAEKKEQDFLNQLRPSNVFYFYKKIHNAYTFEIKTG
TNAPNASYKVMNLTKNTVHNMWSGGANTNMWADWLSFNPNDEFAVVAVVDGKEYVVYKDKVQNIMN

Sequences:

>Translated_466_residues
MMKKIPHKLLAVSAFLTITTTYAVIPLETFAIEIEQTNTENMSLSANEEQMKKALQDAGLFAKAMNEYSYLLINNPDVSF
EGITINGNADLPSKIVQDQKNARAHAVTWNTQVKKQLFDTLTGIIEYDTKFENYYETLVEAINTGNGDTLKKGITDLQGG
IQQNQKSAKALKEELIQLKNAIGEDVRTFGSHKETLQSILKNQGADVEADQKRLEDLLGQVKYQKDIESKGLDMVKIPFI
PTLIAGGIMIGDARGKLGWLEPELAKLRQTVDYKITLNRVVGVAFHNISDMHSMLDSAITALTYMSTQWEDLDSQYSGVL
GHIDKADQKADQNKYKFLTPSLNAAKNSWKTLKTDVVTLQEGIKIAEKKEQDFLNQLRPSNVFYFYKKIHNAYTFEIKTG
TNAPNASYKVMNLTKNTVHNMWSGGANTNMWADWLSFNPNDEFAVVAVVDGKEYVVYKDKVQNIMN
>Mature_466_residues
MMKKIPHKLLAVSAFLTITTTYAVIPLETFAIEIEQTNTENMSLSANEEQMKKALQDAGLFAKAMNEYSYLLINNPDVSF
EGITINGNADLPSKIVQDQKNARAHAVTWNTQVKKQLFDTLTGIIEYDTKFENYYETLVEAINTGNGDTLKKGITDLQGG
IQQNQKSAKALKEELIQLKNAIGEDVRTFGSHKETLQSILKNQGADVEADQKRLEDLLGQVKYQKDIESKGLDMVKIPFI
PTLIAGGIMIGDARGKLGWLEPELAKLRQTVDYKITLNRVVGVAFHNISDMHSMLDSAITALTYMSTQWEDLDSQYSGVL
GHIDKADQKADQNKYKFLTPSLNAAKNSWKTLKTDVVTLQEGIKIAEKKEQDFLNQLRPSNVFYFYKKIHNAYTFEIKTG
TNAPNASYKVMNLTKNTVHNMWSGGANTNMWADWLSFNPNDEFAVVAVVDGKEYVVYKDKVQNIMN

Specific function: Cytotoxic protein, part of the enterotoxin complex. Responsible for binding to erythrocytes. This enterotoxin is thought to be the cause of the diarrheal form of gastroenteritis caused by food-borne strains of B.cereus [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008414
- InterPro:   IPR010356 [H]

Pfam domain/function: PF05791 Bacillus_HBL [H]

EC number: NA

Molecular weight: Translated: 52366; Mature: 52366

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKIPHKLLAVSAFLTITTTYAVIPLETFAIEIEQTNTENMSLSANEEQMKKALQDAGL
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCCCEECCCHHHHHHHHHHHHH
FAKAMNEYSYLLINNPDVSFEGITINGNADLPSKIVQDQKNARAHAVTWNTQVKKQLFDT
HHHHHCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHH
LTGIIEYDTKFENYYETLVEAINTGNGDTLKKGITDLQGGIQQNQKSAKALKEELIQLKN
HHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGEDVRTFGSHKETLQSILKNQGADVEADQKRLEDLLGQVKYQKDIESKGLDMVKIPFI
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH
PTLIAGGIMIGDARGKLGWLEPELAKLRQTVDYKITLNRVVGVAFHNISDMHSMLDSAIT
HHHHHCCEEEECCCCCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
ALTYMSTQWEDLDSQYSGVLGHIDKADQKADQNKYKFLTPSLNAAKNSWKTLKTDVVTLQ
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
EGIKIAEKKEQDFLNQLRPSNVFYFYKKIHNAYTFEIKTGTNAPNASYKVMNLTKNTVHN
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCEEEEEEECCCCCCCCCEEEEECHHHHHHH
MWSGGANTNMWADWLSFNPNDEFAVVAVVDGKEYVVYKDKVQNIMN
HHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEEEHHHHHHHCC
>Mature Secondary Structure
MMKKIPHKLLAVSAFLTITTTYAVIPLETFAIEIEQTNTENMSLSANEEQMKKALQDAGL
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCCCEECCCHHHHHHHHHHHHH
FAKAMNEYSYLLINNPDVSFEGITINGNADLPSKIVQDQKNARAHAVTWNTQVKKQLFDT
HHHHHCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHH
LTGIIEYDTKFENYYETLVEAINTGNGDTLKKGITDLQGGIQQNQKSAKALKEELIQLKN
HHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGEDVRTFGSHKETLQSILKNQGADVEADQKRLEDLLGQVKYQKDIESKGLDMVKIPFI
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH
PTLIAGGIMIGDARGKLGWLEPELAKLRQTVDYKITLNRVVGVAFHNISDMHSMLDSAIT
HHHHHCCEEEECCCCCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
ALTYMSTQWEDLDSQYSGVLGHIDKADQKADQNKYKFLTPSLNAAKNSWKTLKTDVVTLQ
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
EGIKIAEKKEQDFLNQLRPSNVFYFYKKIHNAYTFEIKTGTNAPNASYKVMNLTKNTVHN
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCEEEEEEECCCCCCCCCEEEEECHHHHHHH
MWSGGANTNMWADWLSFNPNDEFAVVAVVDGKEYVVYKDKVQNIMN
HHCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7693651; 8319899 [H]