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The map label for this gene is 218232374

Identifier: 218232374

GI number: 218232374

Start: 2248864

End: 2250057

Strand: Reverse

Name: 218232374

Synonym: BCB4264_A2345

Alternate gene names: NA

Gene position: 2250057-2248864 (Counterclockwise)

Preceding gene: 218235654

Following gene: 218232049

Centisome position: 41.52

GC content: 37.19

Gene sequence:

>1194_bases
TTGAAAAACAAAATCATCGTTTTCCTATCTGTTTTGTCATTTATTATTGGTGGTTTCTTCTTTAACACGAATACTTCAAG
CGCTGAAACATCATCTACTGATTACGTTCCTAACCAATTAATCGTTAAGTTCAAACAAAATGCATCTTTAAGTAATGTGC
AATCTTTTCATAAATCTGTCGGAGCTAATGTCTTATCTAAAGATGATAAGTTAGGTTTTGAAGTCGTACAATTTTCAAAA
GGTACTGTAAAAGAAAAAATAAAGAGCTATAAAAATAATCCAGATGTGGAATATGCAGAACCGAATTATTACGTTCACGC
CTTTTGGACTCCAAACGACCCATATTTTAATAATCAATACGGGTTACAAAAGATTCAAGCTCCACAAGCTTGGGATAGCC
AACGAAGTGATCCTGGTGTAAAAGTAGCTATTATTGATACAGGAGTTCAAGGCTCACACCCTGATCTGGCTTCGAAAGTA
ATTTACGGGCATGATTATGTTGATAACGACAATACATCTGATGATGGTAATGGTCATGGTACACATTGCGCTGGAATTAC
TGGAGCACTTACGAATAACAGCGTCGGAATTGCTGGTGTTGCCCCACAAACTTCAATTTATGCTGTCCGCGTATTAGATA
ATCAAGGAAGTGGTACTCTTGATGCTGTAGCGCAAGGTATTCGAGAAGCTGCTGATTCGGGTGCAAAAGTAATTAGTTTA
AGTTTAGGAGCTCCAAATGGTGGTACTGCATTACAACAAGCCGTTCAATATGCATGGAATAAAGGCTCTGTTATAGTTGC
AGCTGCTGGAAATGCTGGAAATACAAAAGCTAATTACCCTGCTTATTACAGCGAAGTAATTGCAGTTGCTTCTACAGATC
AATCAGATAGAAAATCTTCATTCTCTACTTATGGTAGCTGGGTAGATGTTGCAGCACCAGGTTCAAATATATATTCAACA
TATAAAGGAAGTACGTATCAATCATTAAGTGGTACATCTATGGCAACACCTCATGTTGCAGGAGTCGCAGCTCTTTTAGC
AAATCAAGGATATAGCAATACACAAATCCGCCAAATTATTGAGTCTACTACTGATAAAATTAGTGGTACAGGTACGTACT
GGAAAAACGGTAGAGTCAATGCATATAAGGCTGTACAATACGCTAAGCAATTACAAGAAAATAAAGCTTCTTAA

Upstream 100 bases:

>100_bases
TAAATGTCATAAATCGTATGGTCTAACTATATAGTTGAAAAGGAATGTGACATTAAAGTGTCACTGAAAAACTCATCCAA
GAAAAGGGAGGAAAAATCTT

Downstream 100 bases:

>100_bases
TAAATAAAGTAAAATTTTAATCAGTCGATCTACCATTAATGCCGGATAAAATAGAAGGAGAGACTTCTACAATTAAAGCC
TCTCCTTTTTACAAACTATA

Product: alkaline serine protease, subtilase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGANVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHAFWTPNDPYFNNQYGLQKIQAPQAWDSQRSDPGVKVAIIDTGVQGSHPDLASKV
IYGHDYVDNDNTSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQENKAS

Sequences:

>Translated_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGANVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHAFWTPNDPYFNNQYGLQKIQAPQAWDSQRSDPGVKVAIIDTGVQGSHPDLASKV
IYGHDYVDNDNTSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQENKAS
>Mature_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGANVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHAFWTPNDPYFNNQYGLQKIQAPQAWDSQRSDPGVKVAIIDTGVQGSHPDLASKV
IYGHDYVDNDNTSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQENKAS

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=265, Percent_Identity=30.188679245283, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI31317307, Length=269, Percent_Identity=30.8550185873606, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI27894285, Length=361, Percent_Identity=24.9307479224377, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336188, Length=360, Percent_Identity=24.7222222222222, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336190, Length=360, Percent_Identity=24.7222222222222, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI20336180, Length=313, Percent_Identity=25.5591054313099, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4505577, Length=313, Percent_Identity=25.5591054313099, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20336186, Length=360, Percent_Identity=24.7222222222222, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI20336182, Length=313, Percent_Identity=25.5591054313099, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI20336184, Length=312, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4505579, Length=300, Percent_Identity=25.6666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI76443679, Length=316, Percent_Identity=26.5822784810127, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=395, Percent_Identity=23.2911392405063, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25141268, Length=395, Percent_Identity=23.2911392405063, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71988308, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=272, Percent_Identity=28.3088235294118, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=380, Percent_Identity=31.3157894736842, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324576, Length=219, Percent_Identity=40.6392694063927, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319893, Length=236, Percent_Identity=36.864406779661, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324091, Length=333, Percent_Identity=26.7267267267267, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550681, Length=289, Percent_Identity=25.9515570934256, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642494, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642490, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45555723, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642492, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281360987, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642488, Length=281, Percent_Identity=28.4697508896797, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642484, Length=281, Percent_Identity=28.4697508896797, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642486, Length=281, Percent_Identity=28.4697508896797, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.66 [H]

Molecular weight: Translated: 42334; Mature: 42334

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GANVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHAFWTPNDPYFNNQY
CCHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPQAWDSQRSDPGVKVAIIDTGVQGSHPDLASKVIYGHDYVDNDNTSDDGNGHG
CHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQENKAS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GANVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHAFWTPNDPYFNNQY
CCHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPQAWDSQRSDPGVKVAIIDTGVQGSHPDLASKVIYGHDYVDNDNTSDDGNGHG
CHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQENKAS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2647518; 2689655; 2196375; 1993669 [H]