Click here to switch to the map view.

The map label for this gene is yhxA [H]

Identifier: 218232230

GI number: 218232230

Start: 1597149

End: 1598501

Strand: Direct

Name: yhxA [H]

Synonym: BCB4264_A1673

Alternate gene names: 218232230

Gene position: 1597149-1598501 (Clockwise)

Preceding gene: 218234094

Following gene: 218234469

Centisome position: 29.47

GC content: 38.51

Gene sequence:

>1353_bases
ATGATGAAAACGAAGCAAACTGATGAATTATTAGCAAAAGATGAGCAATATGTTTGGCACGGAATGCGTCCCTTTAGTCC
AAATAGTACAATGGTAGGGGCAAAAGCTGAAGGGTGCTGGGTTGAAGATATACAAGGAAAAAGATATTTAGATGGTATGA
GTGGCCTTTGGTGTGTGAATAGTGGATATGGAAGAAAAGAGCTCGCAGAAGCGGCTTATAAGCAATTACAAACATTATCA
TACTTTCCAATGTCACAATCCCATGAGCCAGCTATAAAGCTTGCTGAAAAGTTAAATGAGTGGCTTGGGGGAGAGTATGT
TATTTTCTTCTCAAATAGTGGTTCAGAAGCGAACGAAACAGCTTTTAAAATAGCAAGACAATACTATGCTCAAAAAGGTG
AACCACATCGTTATAAATTTATGTCACGTTATCGTGGGTATCATGGGAATACAATGGCGACAATGGCAGCGACGGGACAA
GCGCAGCGTAGATATCAATATGAACCGTTTGCTTCAGGTTTTTTACACGTAACACCACCGGATTGTTACCGTATGCCTGG
GATTGAAGGGCAGCATATTTATGATGTAGAATGTGTGAAAGAAGTCGATCGTGTTATGACGTGGGAATTAAGTGAAACAA
TTGCCGCTTTTATTATGGAACCAATTATTACAGGCGGGGGCATATTAATGCCACCACAAGACTATATGAAAGCTGTTCAT
GAGACGTGTCAAAAACACGGTGCCTTGCTTATTAGTGATGAAGTAATTTGCGGTTTCGGTCGTACAGGAAAAGCATTTGG
GTTTATGAATTATGATGTGAAGCCAGATATTATTACAATGGCAAAGGGCATTACGAGCGCATATTTACCATTATCTGCAA
CAGCTGTGAAAAAAGAAATATATGAGGCTTTTAAAGGTAAAGGAGAATATGAATTCTTCCGCCATATTAATACATTTGGT
GGAAATCCAGCAGCTTGTGCATTAGCACTTAAAAACTTAGAGATTATGGAAAATGAAAATTTAATCGAGCGATCTGCGCA
AATGGGTTCCCTTTTATTAGAGCAACTAAAAGATGAAATTGGGGAACATCCGCTTGTTGGGAATATTAGAGGAAAAGGCC
TATTAGTTGGAATTGAATTAGTAAATGATAAAGAGACGAAAGAGCCAATTGATAACGACAAAATTGCAAGTGTTGTAAAT
GCTTGTAAAGAAAAGGGCTTAATTATAGGACGCAATGGTATGACAACAGTAGGGTATAATAACGTCTTAACATTAGCACC
GCCGCTTATTATTTCAAGTGAAGAAATTGCCTTTGTTGTTGGAACGTTGAAGACGGCGATGGAACGTATTTAA

Upstream 100 bases:

>100_bases
GTCTTAATTTTGTGGAATGAAAATAGCAGGGAGAAATTTAAGTCATCATGGCACCAGCGCAGCTTTTGTGAAAAATAAGT
TGTTATGGAAGGTGGAAGTA

Downstream 100 bases:

>100_bases
TAAATAGAGAGAGGAGCGAGCTTTAATATAAGGCTCGCTTTTGTTTAGTAGGAGGGGACTTTTAATGGATAAATATGATC
CGAACAAACATTATCACATC

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIEGQHIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKDEIGEHPLVGNIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTVGYNNVLTLAPPLIISSEEIAFVVGTLKTAMERI

Sequences:

>Translated_450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIEGQHIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKDEIGEHPLVGNIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTVGYNNVLTLAPPLIISSEEIAFVVGTLKTAMERI
>Mature_450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIEGQHIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKDEIGEHPLVGNIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTVGYNNVLTLAPPLIISSEEIAFVVGTLKTAMERI

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=431, Percent_Identity=32.7146171693735, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=30.9417040358744, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=33.2541567695962, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=33.4123222748815, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=33.756345177665, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4557809, Length=434, Percent_Identity=26.9585253456221, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=30.0911854103343, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI188536080, Length=431, Percent_Identity=23.8979118329466, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI38679950, Length=431, Percent_Identity=23.8979118329466, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI38679946, Length=431, Percent_Identity=23.8979118329466, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.2663438256659, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=30.4849884526559, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=30.4668304668305, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=31.6666666666667, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1786991, Length=449, Percent_Identity=31.4031180400891, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=27.972027972028, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=460, Percent_Identity=31.5217391304348, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=472, Percent_Identity=30.2966101694915, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=436, Percent_Identity=27.7522935779816, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=30, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=23.4986945169713, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=459, Percent_Identity=30.2832244008715, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324432, Length=400, Percent_Identity=27, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324386, Length=474, Percent_Identity=27.0042194092827, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321456, Length=411, Percent_Identity=25.0608272506083, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=31.554524361949, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.3953488372093, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21356575, Length=454, Percent_Identity=30.3964757709251, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=27.816091954023, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281366494, Length=451, Percent_Identity=21.5077605321508, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667139, Length=451, Percent_Identity=21.5077605321508, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667143, Length=451, Percent_Identity=21.5077605321508, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50198; Mature: 50198

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVN
CCCCCCCHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEEC
SGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCC
DCYRMPGIEGQHIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
HHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEI
HHHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
YEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKDEI
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEHPLVGNIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTVGYN
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCC
NVLTLAPPLIISSEEIAFVVGTLKTAMERI
CEEEECCCEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVN
CCCCCCCHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEEC
SGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCC
DCYRMPGIEGQHIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
HHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEI
HHHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
YEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKDEI
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEHPLVGNIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTVGYN
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCC
NVLTLAPPLIISSEEIAFVVGTLKTAMERI
CEEEECCCEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]