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The map label for this gene is sirC [H]

Identifier: 218231491

GI number: 218231491

Start: 2051465

End: 2051950

Strand: Reverse

Name: sirC [H]

Synonym: BCB4264_A2148

Alternate gene names: 218231491

Gene position: 2051950-2051465 (Counterclockwise)

Preceding gene: 218232333

Following gene: 218235747

Centisome position: 37.87

GC content: 35.6

Gene sequence:

>486_bases
ATGTATAACATGTACCCTCTTATGTTTAATCTACAAAATAAAGTTGTCATTATCATTGGTGGAGGTAAAATTGCATATCG
AAAAGCGTCTGGATTAAAAGATACAGGCGCTTTCGTCACTGTTGTCAGCCCAGAAATTTGCGAGGAAATGAAGGAACTTT
CTTATATTACTTGGAAACAAAAAACTTTTAGTAATGATGATATTAAAGATGCTCATCTAATTTATGCAGCTACAAATCAA
CATGCTGTAAATATGATGGTCAAACAGGCCGCTCATGATTTCCAGTGGGTTAACGTTGTAAGTGATGGTACAGCATCATC
GTTTCACACACCTGGTGTCATTCGAAATGATGAATATGTTGTCACTATTTCGACTTCAGGTAAGGACCCATCGTTTACGA
AGCGTATGAAACAGGAATTAACTTCTGTCCTTCCTAAACTTATAAAAAGAATTTCTCGTACTCATAAAATGGAATCTATC
ACTTAG

Upstream 100 bases:

>100_bases
TTGCATACAAAAAAATATAATCACGTCACGACTTGTAACTGTCTTCAGTTTGATACATATATGAAACTAACATTATTAGA
ACGAATGGAGGAATGCATAT

Downstream 100 bases:

>100_bases
CTAAAATAGGAATTAACTGTGAACAAACGTTTTTTAGAGACGTTTGTTCTTTTTGCTTTAGTTTCGTTTTTTAGGATCAG
ACAAACAATTGGACAAGAAT

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MYNMYPLMFNLQNKVVIIIGGGKIAYRKASGLKDTGAFVTVVSPEICEEMKELSYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHDFQWVNVVSDGTASSFHTPGVIRNDEYVVTISTSGKDPSFTKRMKQELTSVLPKLIKRISRTHKMESI
T

Sequences:

>Translated_161_residues
MYNMYPLMFNLQNKVVIIIGGGKIAYRKASGLKDTGAFVTVVSPEICEEMKELSYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHDFQWVNVVSDGTASSFHTPGVIRNDEYVVTISTSGKDPSFTKRMKQELTSVLPKLIKRISRTHKMESI
T
>Mature_161_residues
MYNMYPLMFNLQNKVVIIIGGGKIAYRKASGLKDTGAFVTVVSPEICEEMKELSYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHDFQWVNVVSDGTASSFHTPGVIRNDEYVVTISTSGKDPSFTKRMKQELTSVLPKLIKRISRTHKMESI
T

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis (Probable) [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=152, Percent_Identity=28.2894736842105, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 18164; Mature: 18164

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNMYPLMFNLQNKVVIIIGGGKIAYRKASGLKDTGAFVTVVSPEICEEMKELSYITWKQ
CCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHEEEECC
KTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHDFQWVNVVSDGTASSFHTPGVIRNDEYV
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
VTISTSGKDPSFTKRMKQELTSVLPKLIKRISRTHKMESIT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYNMYPLMFNLQNKVVIIIGGGKIAYRKASGLKDTGAFVTVVSPEICEEMKELSYITWKQ
CCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHEEEECC
KTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHDFQWVNVVSDGTASSFHTPGVIRNDEYV
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
VTISTSGKDPSFTKRMKQELTSVLPKLIKRISRTHKMESIT
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10217486 [H]