Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 218231250

GI number: 218231250

Start: 3046387

End: 3047817

Strand: Reverse

Name: phr [H]

Synonym: BCB4264_A3165

Alternate gene names: 218231250

Gene position: 3047817-3046387 (Counterclockwise)

Preceding gene: 218236125

Following gene: 218231918

Centisome position: 56.24

GC content: 34.52

Gene sequence:

>1431_bases
ATGCAAAACAAAATTATCGTTATGTTTCAAAAAGATTTTCGTTTATATGATAACCCAGCTCTATTTGAGGCTGTTCAGTC
CGGGGAGGTTCTTCCGGTATATGTACAAGATGAAACTTTTTCAATAGGAAGTGCGGCAAAGTGGTGGTTACACCATGCTA
TAATAGATGTCCAAAAGCAACTTAAGGCATTGGGCTCTACTTTAATAATCCGCAAAGGAAATACACAGGAAGAAATACTT
TCTCTCATAAAACAATTAGATATAACGGCTGTATATTGGAATAGTTGTTATGATCCAGACAGGTTAAAATCTAATCAAAA
AATGAAAATGATATTAGAAGATAAAGGTATTATTTGTAAGGAATTTAATTCGCATTTATTATTAGAACCGTGGATTATAA
AAAAGAAGGATAACACTGAATATAAGGTGTTTACGCCTTTTTACAATGCATTTCAAAAGCAGGTAATACCTAAACCTATT
AGCAGAGTACAGAGTATAAAGTGGGGAAGCTCTTTACCAGCAAGCTTATCTGTCTCAGAATTACACTTGTTGCCGACTAT
ACCGTGGACATCTCATATGGAAGCAATATGGGAGCCTACAGAGGAAGGGGCATACAAAACATTTAAGAAATTTTTCTCTA
GTAAATTAGCCTCTTATAGTGAAGGAAGAGATTTTCCAAATCAAAATGCTCATTCAATGTTGGCGCCATATCTTTCATTT
GGCCAAATATCAGTGAAGTTAATGTATCACTACTTAATAAATAAAAGTACCGAAAGACAATGTAGTTTTTTTGAAAAACA
AGTGATTAGTTTTATACGTCAATTAATTTGGAGAGAGTTTTCTTATTATTTGCTATATCACTATCCGTTTACAGCATATA
AACCTCTTAATAAAAACTTTGAACATTTTCCGTGGAATAAGGAAGAGGAGTTATTAAGAGTATGGCAGAAGGGTGAAACT
GGTTATCCGTTTATTGATGCGGGAATGCGAGAACTATGGCAAACCGGTTTTATGCATAATCGGGCAAGAATGGCTGTAGC
CTCTTTTCTTGTAAAGCATTTGTTAATTCCGTGGCAAGAAGGTGCAAAATGGTTTATGGATACACTACTAGATGCTGATA
TTGCAAATAATACAATGGGATGGCAATGGGTTGCTGGAAGTGGAGCAGATGCATCACCGTACTTTCGTATTTTTAATCCT
ATCACACAAGGAGAAAAGTTTGATAAAAATGGAGAGTATATAAGAAGATGGATACCAGAATTAAGAGATATCCCAAACAA
ATATATACATAAACCTTGGGAAGCACCTGAGCATATTTTACAAAAATCCAATATAAAACTTGGGAATACATATCCTTATC
CGATTGTTGATCATAAGGCAGCACGAGAGAGAGCCCTTTGTGCATATAAAAATATGAAAGAATTTGTATGA

Upstream 100 bases:

>100_bases
TACGATTACAAAGAATTATTAATATAATAATGCAAAAGTAAAAAAAGAGGATTATTCACATAAAGAATCTATTATGTTTT
AAGAGTAAGAGGGGATAGCC

Downstream 100 bases:

>100_bases
AATAGGTTAAACAATATGTATTTAGAATATTATCCATTATAAGGACATACTAATCATATAAAGTTTCTATAATCTTCTAG
TAAAAAGGAGAATGTTTATG

Product: deoxyribodipyrimidine photolyase family protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MQNKIIVMFQKDFRLYDNPALFEAVQSGEVLPVYVQDETFSIGSAAKWWLHHAIIDVQKQLKALGSTLIIRKGNTQEEIL
SLIKQLDITAVYWNSCYDPDRLKSNQKMKMILEDKGIICKEFNSHLLLEPWIIKKKDNTEYKVFTPFYNAFQKQVIPKPI
SRVQSIKWGSSLPASLSVSELHLLPTIPWTSHMEAIWEPTEEGAYKTFKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLMYHYLINKSTERQCSFFEKQVISFIRQLIWREFSYYLLYHYPFTAYKPLNKNFEHFPWNKEEELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRARMAVASFLVKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRRWIPELRDIPNKYIHKPWEAPEHILQKSNIKLGNTYPYPIVDHKAARERALCAYKNMKEFV

Sequences:

>Translated_476_residues
MQNKIIVMFQKDFRLYDNPALFEAVQSGEVLPVYVQDETFSIGSAAKWWLHHAIIDVQKQLKALGSTLIIRKGNTQEEIL
SLIKQLDITAVYWNSCYDPDRLKSNQKMKMILEDKGIICKEFNSHLLLEPWIIKKKDNTEYKVFTPFYNAFQKQVIPKPI
SRVQSIKWGSSLPASLSVSELHLLPTIPWTSHMEAIWEPTEEGAYKTFKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLMYHYLINKSTERQCSFFEKQVISFIRQLIWREFSYYLLYHYPFTAYKPLNKNFEHFPWNKEEELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRARMAVASFLVKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRRWIPELRDIPNKYIHKPWEAPEHILQKSNIKLGNTYPYPIVDHKAARERALCAYKNMKEFV
>Mature_476_residues
MQNKIIVMFQKDFRLYDNPALFEAVQSGEVLPVYVQDETFSIGSAAKWWLHHAIIDVQKQLKALGSTLIIRKGNTQEEIL
SLIKQLDITAVYWNSCYDPDRLKSNQKMKMILEDKGIICKEFNSHLLLEPWIIKKKDNTEYKVFTPFYNAFQKQVIPKPI
SRVQSIKWGSSLPASLSVSELHLLPTIPWTSHMEAIWEPTEEGAYKTFKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
GQISVKLMYHYLINKSTERQCSFFEKQVISFIRQLIWREFSYYLLYHYPFTAYKPLNKNFEHFPWNKEEELLRVWQKGET
GYPFIDAGMRELWQTGFMHNRARMAVASFLVKHLLIPWQEGAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNP
ITQGEKFDKNGEYIRRWIPELRDIPNKYIHKPWEAPEHILQKSNIKLGNTYPYPIVDHKAARERALCAYKNMKEFV

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=475, Percent_Identity=30.9473684210526, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4758072, Length=476, Percent_Identity=31.0924369747899, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI188536103, Length=435, Percent_Identity=29.8850574712644, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1786926, Length=483, Percent_Identity=34.7826086956522, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6324962, Length=512, Percent_Identity=28.3203125, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137248, Length=507, Percent_Identity=27.810650887574, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24585455, Length=507, Percent_Identity=27.810650887574, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24648152, Length=511, Percent_Identity=24.853228962818, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55965; Mature: 55965

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKIIVMFQKDFRLYDNPALFEAVQSGEVLPVYVQDETFSIGSAAKWWLHHAIIDVQKQ
CCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LKALGSTLIIRKGNTQEEILSLIKQLDITAVYWNSCYDPDRLKSNQKMKMILEDKGIICK
HHHCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEECCCCCEEE
EFNSHLLLEPWIIKKKDNTEYKVFTPFYNAFQKQVIPKPISRVQSIKWGSSLPASLSVSE
CCCCCEEECCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHH
LHLLPTIPWTSHMEAIWEPTEEGAYKTFKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
EEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
GQISVKLMYHYLINKSTERQCSFFEKQVISFIRQLIWREFSYYLLYHYPFTAYKPLNKNF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCC
EHFPWNKEEELLRVWQKGETGYPFIDAGMRELWQTGFMHNRARMAVASFLVKHLLIPWQE
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNPITQGEKFDKNGEYIRRWIPE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHHHH
LRDIPNKYIHKPWEAPEHILQKSNIKLGNTYPYPIVDHKAARERALCAYKNMKEFV
HHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKIIVMFQKDFRLYDNPALFEAVQSGEVLPVYVQDETFSIGSAAKWWLHHAIIDVQKQ
CCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LKALGSTLIIRKGNTQEEILSLIKQLDITAVYWNSCYDPDRLKSNQKMKMILEDKGIICK
HHHCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEECCCCCEEE
EFNSHLLLEPWIIKKKDNTEYKVFTPFYNAFQKQVIPKPISRVQSIKWGSSLPASLSVSE
CCCCCEEECCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHH
LHLLPTIPWTSHMEAIWEPTEEGAYKTFKKFFSSKLASYSEGRDFPNQNAHSMLAPYLSF
EEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
GQISVKLMYHYLINKSTERQCSFFEKQVISFIRQLIWREFSYYLLYHYPFTAYKPLNKNF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCC
EHFPWNKEEELLRVWQKGETGYPFIDAGMRELWQTGFMHNRARMAVASFLVKHLLIPWQE
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GAKWFMDTLLDADIANNTMGWQWVAGSGADASPYFRIFNPITQGEKFDKNGEYIRRWIPE
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHHHH
LRDIPNKYIHKPWEAPEHILQKSNIKLGNTYPYPIVDHKAARERALCAYKNMKEFV
HHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]