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The map label for this gene is guaA [H]

Identifier: 218231195

GI number: 218231195

Start: 259457

End: 260995

Strand: Direct

Name: guaA [H]

Synonym: BCB4264_A0300

Alternate gene names: 218231195

Gene position: 259457-260995 (Clockwise)

Preceding gene: 218235093

Following gene: 218233002

Centisome position: 4.79

GC content: 39.83

Gene sequence:

>1539_bases
TTGAAGAAACAACACGATACAATTATCGTTTTAGATTTTGGAAGTCAATACAATCAGTTAATAGCACGTCGAATTCGTGA
GTTCGGTGTATACAGTGAACTTCATCCACATACAATTACTGCAGAAGAAATTAAAGCAATGAATCCAAAAGGGATTATTT
TCTCTGGTGGACCAAATAGTGTATACGGTGAAGGTGCATTACATTGTGATGAAAAAATCTTTGAACTAGGTTTACCAATC
TTCGGTATTTGTTACGGTATGCAGCTTATGACGCAACACTTCGGTGGTAAAGTAGAGCGTGCAAATCACCGTGAGTACGG
AAAAGCTGTTCTTAAAGTAGAGAACGAATCAAAATTATATGCGAACCTTCCAGAAGAGCAAGTTGTATGGATGAGTCATG
GTGACTTAGTAACTGGTTTACCTGAAGGATTCGTAGTAGACGCAACAAGTGAGTCTTGCCCAATTGCTGGTATGAGCAAT
GAAGCGAAAAACTTATACGGTGTACAATTCCACCCAGAAGTACGTCACTCTGAGCACGGTAACGATTTAATTAAAAACTT
CGTATTCGGCGTATGTGGTTGTTCTGAAGGATGGAACATGGAGAACTTTATCGAAGTAGAATTAGAAAAGATCCGTGAAA
CTGTTGGAGACAAAAAAGTACTATGCGCACTTAGCGGTGGTGTAGACTCTTCTGTTGTAGCAGTATTAATCCATAAAGCA
ATCGGCGACCAATTAACATGTATTTTCGTTGATCACGGTTTACTTCGTAAAGGCGAAGCGGAAGGCGTTATGAAAACATT
TAGTGAAGGCTTCCATATGAACGTTATTAAAGTGGATGCAAAAGACCGCTTCATGGACAAGTTAAAAGGTGTAGAAGATC
CAGAACAAAAACGTAAAATTATCGGTAACGAATTCATTTACGTATTCGATGATGAAGCATCTAAATTACAAGGTATGGAC
TTCCTAGCACAAGGTACACTTTACACAGATATCGTTGAAAGTGGTACAGCAACTGCACAAACAATTAAATCTCACCATAA
CGTTGGTGGACTTCCAGAAGACATGCAGTTCAAATTAATTGAGCCTTTAAATACGTTATTTAAAGATGAAGTACGTGTAT
TAGGATCTGAACTAGGAATTCCTGATGAAATCGTATGGCGTCAACCATTCCCAGGACCGGGTCTTGGTATTCGTGTATTA
GGTGAAATCACAGAAGAGAAATTAGAAATCGTTCGTGAATCTGATGCGATTTTACGTGAAGAAATTATTAAAGCGGGCTT
AGATCGTGAAATTTGGCAATACTTCACTGCGCTTCCTGGTATGCGTAGCGTAGGTGTTATGGGTGACGAGCGTACTTACG
ATTACACAGTAGGTATCCGCGCGGTAACATCTATCGACGGTATGACAGCTGACTGGGCACGTATCCCTTGGGACGTATTA
GAGAAAATCTCTGTACGTATCGTAAACGAAGTAAAACACGTTAACCGTATCGTGTATGATGTAACGAGTAAGCCACCAGC
AACTATTGAGTGGGAATAG

Upstream 100 bases:

>100_bases
ACTAGAGGCGGAGGACTGGCTTTTTTTATTATATTGGTAATGCTTTTCGCCAAATTGGTGAAAATATTTATATACGAGAA
CTAACGTTGGGGTGATTATT

Downstream 100 bases:

>100_bases
TATTTATAAAAAGGTCCATCTATTGCTTATGCATAGGTGGATCTTTTTTGTTTTGGTGTTAATACGAACAAAAATATAAA
ATTTTATAAAAATGTTCGTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGEGALHCDEKIFELGLPI
FGICYGMQLMTQHFGGKVERANHREYGKAVLKVENESKLYANLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EAKNLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKVDAKDRFMDKLKGVEDPEQKRKIIGNEFIYVFDDEASKLQGMD
FLAQGTLYTDIVESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIIKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRIVYDVTSKPPATIEWE

Sequences:

>Translated_512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGEGALHCDEKIFELGLPI
FGICYGMQLMTQHFGGKVERANHREYGKAVLKVENESKLYANLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EAKNLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKVDAKDRFMDKLKGVEDPEQKRKIIGNEFIYVFDDEASKLQGMD
FLAQGTLYTDIVESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIIKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRIVYDVTSKPPATIEWE
>Mature_512_residues
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNSVYGEGALHCDEKIFELGLPI
FGICYGMQLMTQHFGGKVERANHREYGKAVLKVENESKLYANLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSN
EAKNLYGVQFHPEVRHSEHGNDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKVDAKDRFMDKLKGVEDPEQKRKIIGNEFIYVFDDEASKLQGMD
FLAQGTLYTDIVESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVL
GEITEEKLEIVRESDAILREEIIKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
EKISVRIVNEVKHVNRIVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=546, Percent_Identity=36.996336996337, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=52.3255813953488, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1789760, Length=154, Percent_Identity=37.012987012987, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=36.2190812720848, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=36.2190812720848, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=36.0424028268551, Blast_Score=309, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=53.9805825242718, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322638, Length=154, Percent_Identity=32.4675324675325, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=35.0909090909091, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57276; Mature: 57276

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNS
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCC
VYGEGALHCDEKIFELGLPIFGICYGMQLMTQHFGGKVERANHREYGKAVLKVENESKLY
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEECCCCCEE
ANLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSNEAKNLYGVQFHPEVRHSEHG
ECCCCCEEEEEECCCEEECCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
NDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKVDAKDRFMDKLKGVEDPEQKRKI
HCCCEEEEEECCCHHCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCHHHHHHH
IGNEFIYVFDDEASKLQGMDFLAQGTLYTDIVESGTATAQTIKSHHNVGGLPEDMQFKLI
CCCCEEEEECCCHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHH
EPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILRE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIIKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCHHHH
EKISVRIVNEVKHVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECC
>Mature Secondary Structure
MKKQHDTIIVLDFGSQYNQLIARRIREFGVYSELHPHTITAEEIKAMNPKGIIFSGGPNS
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCC
VYGEGALHCDEKIFELGLPIFGICYGMQLMTQHFGGKVERANHREYGKAVLKVENESKLY
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEECCCCCEE
ANLPEEQVVWMSHGDLVTGLPEGFVVDATSESCPIAGMSNEAKNLYGVQFHPEVRHSEHG
ECCCCCEEEEEECCCEEECCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
NDLIKNFVFGVCGCSEGWNMENFIEVELEKIRETVGDKKVLCALSGGVDSSVVAVLIHKA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFHMNVIKVDAKDRFMDKLKGVEDPEQKRKI
HCCCEEEEEECCCHHCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCHHHHHHH
IGNEFIYVFDDEASKLQGMDFLAQGTLYTDIVESGTATAQTIKSHHNVGGLPEDMQFKLI
CCCCEEEEECCCHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHH
EPLNTLFKDEVRVLGSELGIPDEIVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILRE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIIKAGLDREIWQYFTALPGMRSVGVMGDERTYDYTVGIRAVTSIDGMTADWARIPWDVL
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCHHHH
EKISVRIVNEVKHVNRIVYDVTSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA