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The map label for this gene is ubiE [H]

Identifier: 218231176

GI number: 218231176

Start: 1497953

End: 1498666

Strand: Direct

Name: ubiE [H]

Synonym: BCB4264_A1569

Alternate gene names: 218231176

Gene position: 1497953-1498666 (Clockwise)

Preceding gene: 218231767

Following gene: 218233341

Centisome position: 27.64

GC content: 37.54

Gene sequence:

>714_bases
ATGCAACAATCAAAAGAAGAAAGAGTACATGACGTATTTGAAAAGATTTCTGATAAATACGATGTGATGAATTCTGTAAT
TAGTTTTCAAAGACATAAAGCGTGGCGGAAAGAAACGATGCGAATTATGGATGTACAACCAGGCAGTCAAGCGCTTGATG
TATGCTGTGGAACCGCAGATTGGACAATTGCGCTAGCTGGAGCCGTAGGTGAGCAAGGAAAGGTTGTTGGCTTAGACTTC
AGTGAAAATATGTTATCTGTCGGTAAGCAAAAGGTAGAGGCGTTACAATTAAAACAAGTAGAACTTCTACATGGGAATGC
AATGGAACTTCCGTTTGAAGATAATACGTTTGATTATGTGACGATTGGGTTTGGTTTACGTAACGTACCGGATTATATGC
ACGTATTAAAAGAAATGACGCGTGTAGTAAAACCAGGTGGAAAAGTAATCTGTTTAGAAACATCTCAACCAACAATGATT
GGTTTTCGACAAGGGTATATTTTATACTTTAAATATATCATGCCATTATTTGGAAAGATGTTTGCGAAAAGTTATAAAGA
ATATTCATGGCTTCAAGAATCTGCTAGTACGTTCCCAGGGATGAAAGAATTGGCTCAAATGTTTGAGCAAGCTGGACTTG
AACGTGTGCAAGTGAAACCATTTACTTTTGGGGTAGCAGCAATGCATTTAGGTATTAAACCAGAATCAAAATAG

Upstream 100 bases:

>100_bases
AACAATTTTTAGAAAATCACACAGACATAAATGAAATAAATTCTGTGTTAAGGAATAAATAGAAGACATAAGCAATTTTA
CATTGGAAGAAGGTACGAGC

Downstream 100 bases:

>100_bases
AAAAAAGAAGTTTTAGGTTAAGGTGAACAATATGAAGTTACAACTTATGTACTCTTTTTTACGATCGGATATTAATGTGA
TAGAAAAAGAATTAAAAAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVQPGSQALDVCCGTADWTIALAGAVGEQGKVVGLDF
SENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMI
GFRQGYILYFKYIMPLFGKMFAKSYKEYSWLQESASTFPGMKELAQMFEQAGLERVQVKPFTFGVAAMHLGIKPESK

Sequences:

>Translated_237_residues
MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVQPGSQALDVCCGTADWTIALAGAVGEQGKVVGLDF
SENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMI
GFRQGYILYFKYIMPLFGKMFAKSYKEYSWLQESASTFPGMKELAQMFEQAGLERVQVKPFTFGVAAMHLGIKPESK
>Mature_237_residues
MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVQPGSQALDVCCGTADWTIALAGAVGEQGKVVGLDF
SENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMI
GFRQGYILYFKYIMPLFGKMFAKSYKEYSWLQESASTFPGMKELAQMFEQAGLERVQVKPFTFGVAAMHLGIKPESK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=266, Percent_Identity=34.2105263157895, Blast_Score=151, Evalue=5e-37,
Organism=Escherichia coli, GI48994983, Length=233, Percent_Identity=39.4849785407725, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1786404, Length=91, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557039, Length=236, Percent_Identity=33.0508474576271, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323526, Length=253, Percent_Identity=29.2490118577075, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24641702, Length=243, Percent_Identity=33.7448559670782, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26902; Mature: 26902

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVQPGSQALDVCCGTAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCC
WTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYV
CEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
TIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKM
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHH
FAKSYKEYSWLQESASTFPGMKELAQMFEQAGLERVQVKPFTFGVAAMHLGIKPESK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCEEHHHHHHEECCCCCCC
>Mature Secondary Structure
MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVQPGSQALDVCCGTAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCC
WTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYV
CEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
TIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKM
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHH
FAKSYKEYSWLQESASTFPGMKELAQMFEQAGLERVQVKPFTFGVAAMHLGIKPESK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCEEHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA