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The map label for this gene is hipA [C]

Identifier: 213692936

GI number: 213692936

Start: 2296387

End: 2297742

Strand: Direct

Name: hipA [C]

Synonym: Blon_2080

Alternate gene names: 213692936

Gene position: 2296387-2297742 (Clockwise)

Preceding gene: 213692935

Following gene: 213692939

Centisome position: 81.07

GC content: 48.53

Gene sequence:

>1356_bases
ATGACAAAAATCAAGATGCTTAACGTTTTTTTGGAAGGCATCCACTTAGGAGTCCTCCAAGAGGATCTTTTCGGCAATCA
TACTTTCACCTATGACTTATCAAGCCCCAGCAATGCGCAGTTATCATTATCGATGCCGCGCCGCGCAGCACCATGGAAGG
GCATTGCAGTCGAAGCGTATATTGATGGGATCCTTCCTGATGACCCAGCAGTCAGGCAACGCATAGCACGTTTACATGGC
GTTAATGCGCGCAATCCTTTTTCGCTACTCACCGCCGTTGGCCTTGACTGTGGTGGAGGGGTGCAATTCATTCCCGAAAA
ATCAGACTCTCTAATCACAGAAACGATTACGCCAATCAGCAAAGAACAAATCGGACAACGACTCGAAAAAATAACAGGGG
AACAGCCGCCTTCCTGGCAAAGCCCCGATGAACATTGGTCTTTAAACGGCGCACATGACAAACTCGCCGTCAGATTCACC
AATGGACAATGGTATGAGGCCGAAGGCAAAGCCGCCACTACTCACATCATCAAACCCGGAGTAAGTAGTCTGCACGAACA
GGCATTCAATGAATACATATGTCTTAATACCGCAAAGAAACTCGGAATTCCCGTTGCACAATCCGACTATTGTCTTTTCG
GCGGCATTCCGGCAATAGTCAGCGAACGATGGGATCGCATTGTCGACAACAGCGTCGCACCCGCAATCGTGAAGCGCATT
CATCAGGAGGATTTATGCCAAGCGATGAGTGTTATGACCGACCAAAAGTATGAATCAGAGGGAGGCCCAGGAGCCACTGA
CATCGTGCATTTCATGCGCGACAATGGTTTGCCAGAGGACAGCGTACATCTTTTCTTCAAAGCGTTGGTTTTCAACTACA
TCATTGCCGGCGGAGATGCACATGCCAAGAATTATGCTATTTTGGAACCAATCGGCGGGACACCCCATCTTGCACCGCTA
TACGATATCGCATCGTATTTTGCCTACGATACACAGCGCAAAGAACGTAAACTTGCGATGCGCATTGGAGGAGAATATTC
ATGGGAACGTATCGATTTACGTCACTGGCATCGATTTGCCGAAGCATGTACAGGACAATCCGATTGGGAGACGCTCGGTA
ATATACTTCTCGAATATGCATTGAGCACATTGCCAGCATTCCTACAAGTTTCTGAGGAAGCTCTTGCACTGGCACAACAG
CTGGAGCAATCCGCCACCGGCGAACAAACCGCAAATAAATTCGAACTGATTATGCGAATCCGTGACGGCATAGCGGCACA
AAGCACGCGTATATTGAGCTGGTTCGCAACAGCAAATGGTGGAAATGCGCGCTACTGTTATTCGCGGTTCCTTTGA

Upstream 100 bases:

>100_bases
CCAGTGCGACAATATCTCGACACATTGCATGACCTATCCTCAGCATCCGACGCATATGACCTTACAGGGGCAGACGAACC
GAACGACAGCGAGGAATACG

Downstream 100 bases:

>100_bases
CAATTAGGCTAGAGCACAATCACTTACGGCTTCGGCTCAACTTCCGGTTCCTTCTCCTGATCATCTTTCGGTTTCTTCTC
CTGATCAGGCGCCGGGGCGC

Product: HipA domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTKIKMLNVFLEGIHLGVLQEDLFGNHTFTYDLSSPSNAQLSLSMPRRAAPWKGIAVEAYIDGILPDDPAVRQRIARLHG
VNARNPFSLLTAVGLDCGGGVQFIPEKSDSLITETITPISKEQIGQRLEKITGEQPPSWQSPDEHWSLNGAHDKLAVRFT
NGQWYEAEGKAATTHIIKPGVSSLHEQAFNEYICLNTAKKLGIPVAQSDYCLFGGIPAIVSERWDRIVDNSVAPAIVKRI
HQEDLCQAMSVMTDQKYESEGGPGATDIVHFMRDNGLPEDSVHLFFKALVFNYIIAGGDAHAKNYAILEPIGGTPHLAPL
YDIASYFAYDTQRKERKLAMRIGGEYSWERIDLRHWHRFAEACTGQSDWETLGNILLEYALSTLPAFLQVSEEALALAQQ
LEQSATGEQTANKFELIMRIRDGIAAQSTRILSWFATANGGNARYCYSRFL

Sequences:

>Translated_451_residues
MTKIKMLNVFLEGIHLGVLQEDLFGNHTFTYDLSSPSNAQLSLSMPRRAAPWKGIAVEAYIDGILPDDPAVRQRIARLHG
VNARNPFSLLTAVGLDCGGGVQFIPEKSDSLITETITPISKEQIGQRLEKITGEQPPSWQSPDEHWSLNGAHDKLAVRFT
NGQWYEAEGKAATTHIIKPGVSSLHEQAFNEYICLNTAKKLGIPVAQSDYCLFGGIPAIVSERWDRIVDNSVAPAIVKRI
HQEDLCQAMSVMTDQKYESEGGPGATDIVHFMRDNGLPEDSVHLFFKALVFNYIIAGGDAHAKNYAILEPIGGTPHLAPL
YDIASYFAYDTQRKERKLAMRIGGEYSWERIDLRHWHRFAEACTGQSDWETLGNILLEYALSTLPAFLQVSEEALALAQQ
LEQSATGEQTANKFELIMRIRDGIAAQSTRILSWFATANGGNARYCYSRFL
>Mature_450_residues
TKIKMLNVFLEGIHLGVLQEDLFGNHTFTYDLSSPSNAQLSLSMPRRAAPWKGIAVEAYIDGILPDDPAVRQRIARLHGV
NARNPFSLLTAVGLDCGGGVQFIPEKSDSLITETITPISKEQIGQRLEKITGEQPPSWQSPDEHWSLNGAHDKLAVRFTN
GQWYEAEGKAATTHIIKPGVSSLHEQAFNEYICLNTAKKLGIPVAQSDYCLFGGIPAIVSERWDRIVDNSVAPAIVKRIH
QEDLCQAMSVMTDQKYESEGGPGATDIVHFMRDNGLPEDSVHLFFKALVFNYIIAGGDAHAKNYAILEPIGGTPHLAPLY
DIASYFAYDTQRKERKLAMRIGGEYSWERIDLRHWHRFAEACTGQSDWETLGNILLEYALSTLPAFLQVSEEALALAQQL
EQSATGEQTANKFELIMRIRDGIAAQSTRILSWFATANGGNARYCYSRFL

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=375, Percent_Identity=31.4666666666667, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 50127; Mature: 49996

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKMLNVFLEGIHLGVLQEDLFGNHTFTYDLSSPSNAQLSLSMPRRAAPWKGIAVEAY
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEE
IDGILPDDPAVRQRIARLHGVNARNPFSLLTAVGLDCGGGVQFIPEKSDSLITETITPIS
ECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHCCCC
KEQIGQRLEKITGEQPPSWQSPDEHWSLNGAHDKLAVRFTNGQWYEAEGKAATTHIIKPG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCCEEEHEEECCC
VSSLHEQAFNEYICLNTAKKLGIPVAQSDYCLFGGIPAIVSERWDRIVDNSVAPAIVKRI
HHHHHHHHHCCEEEEECHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
HQEDLCQAMSVMTDQKYESEGGPGATDIVHFMRDNGLPEDSVHLFFKALVFNYIIAGGDA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
HAKNYAILEPIGGTPHLAPLYDIASYFAYDTQRKERKLAMRIGGEYSWERIDLRHWHRFA
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EACTGQSDWETLGNILLEYALSTLPAFLQVSEEALALAQQLEQSATGEQTANKFELIMRI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RDGIAAQSTRILSWFATANGGNARYCYSRFL
HHCHHHHHHHEEEEEEECCCCCCHHHHHHCC
>Mature Secondary Structure 
TKIKMLNVFLEGIHLGVLQEDLFGNHTFTYDLSSPSNAQLSLSMPRRAAPWKGIAVEAY
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEE
IDGILPDDPAVRQRIARLHGVNARNPFSLLTAVGLDCGGGVQFIPEKSDSLITETITPIS
ECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHCCCC
KEQIGQRLEKITGEQPPSWQSPDEHWSLNGAHDKLAVRFTNGQWYEAEGKAATTHIIKPG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEECCCCEEEHEEECCC
VSSLHEQAFNEYICLNTAKKLGIPVAQSDYCLFGGIPAIVSERWDRIVDNSVAPAIVKRI
HHHHHHHHHCCEEEEECHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
HQEDLCQAMSVMTDQKYESEGGPGATDIVHFMRDNGLPEDSVHLFFKALVFNYIIAGGDA
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
HAKNYAILEPIGGTPHLAPLYDIASYFAYDTQRKERKLAMRIGGEYSWERIDLRHWHRFA
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EACTGQSDWETLGNILLEYALSTLPAFLQVSEEALALAQQLEQSATGEQTANKFELIMRI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RDGIAAQSTRILSWFATANGGNARYCYSRFL
HHCHHHHHHHEEEEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]