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The map label for this gene is pyrD [H]

Identifier: 213692921

GI number: 213692921

Start: 2277929

End: 2279080

Strand: Direct

Name: pyrD [H]

Synonym: Blon_2065

Alternate gene names: 213692921

Gene position: 2277929-2279080 (Clockwise)

Preceding gene: 213692908

Following gene: 213692933

Centisome position: 80.41

GC content: 61.55

Gene sequence:

>1152_bases
ATGACTTACGTTTCTGAAAGCTTCTGGCACGACGCCGTCAACAAAGCCACCACCGATCTGTTCACCTTCGGCTACAAGCA
CATCATCAAACCGAACTTCGTGTTCAACCACCGCCCCGATGAGGCACACGATCAGATGATCGAGTTCTGCCATGTCGTCA
AGAACGTCCCGCCGCTGCTGCTCGCCGAGCAGCTTATGCTCGACTACACCGACCCCATTCTGGAAACGAATGTGATGGGC
GTCGATTTCACCAACCCGTTCGGCCTGTCCGCCGGCCTCGACAAGAACTGCGACATGCCCGTGGTGCTGGACCACGCCGG
CTTCGGCTTCGAAACCGTAGGCTCCACCACCTCGCGTCCCTGCTCGGGCAACGCCAAGCCGTGGTTCCACCGTCTGCCTG
AATACGATTCGATGATGGTGCACGTCGGCCTCGCCAACATCGGTTCGGACAAGGTCATCGAGCGCGCCGAGAAGGCTTGG
ACTCAGGCCCGCCAGATGCAGCTGTCCGTGTCGATCGCCCGCACCAACGACGACCAGTGCGGCGATTTGGACGAAGGCAT
TGAGGATTACTGCATTTCGATGCGCCGCGCCGTCGGCCGCACCGCGATGGTGGAGGTCAACGTCTCCTGCCCGAACACGC
ACGTCGGCGAACCGTTCACCACGACTCCGGAAGCGCTCGACCGTCTGTTTACGGCGCTCGACAAGATCGACCGCCCGCAG
CCCACGCTGGTCAAGATGCCGTTGAACAAGCCGTGGGGCGAGTACAAGGAGCTGCTCGATGTGCTGGCCGAGCACAATGT
GCAGGGGCTGTCCATCGCCAATCTGCAGAAGGACCGCACCGGCCTCGAGATTCCGCGCGATTGGGAGGGCGGCCTGTCCG
GCGGCCCGTGCACCAACGCCAGCACCGAGCTGATTCGCAAGGTGTATAAAGAGTATGGCGACCGGTTCGCTATCGCCGGC
ATCGGTGGCGTCTTTACCCCCGAGCAAGCCTATGCGAAGATTCGTTCCGGCTCCAGCTTGGTCATGTTCATCAGCTCGCT
GATGTACCGAGGCCCGCAGCAGATTACCGTGTTGAAGCGCGGTCTGGCCCAGCTGCTGCGCCGTGACGGATTCGAGCACG
TCTCCGATGCCGTCGGCGTAGACGTGGAGTGA

Upstream 100 bases:

>100_bases
CTACGTCTGCGTGTGCCTCGACACGCGGTAGCCCCTTCCCCAATTCGCCTAGGTAGGGATCGCCTAGCCGCACCGGCCCA
AGCGTGAGACAATAGGCGGT

Downstream 100 bases:

>100_bases
ACTCACATATTGCCCTATTACCCATGGGGCGGTAAAACCCTCATGGGGCGGTGATTGTCCCATGGGGCGGTTAGCCAAAT
TTCACATTCCGCAGAATACC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTYVSESFWHDAVNKATTDLFTFGYKHIIKPNFVFNHRPDEAHDQMIEFCHVVKNVPPLLLAEQLMLDYTDPILETNVMG
VDFTNPFGLSAGLDKNCDMPVVLDHAGFGFETVGSTTSRPCSGNAKPWFHRLPEYDSMMVHVGLANIGSDKVIERAEKAW
TQARQMQLSVSIARTNDDQCGDLDEGIEDYCISMRRAVGRTAMVEVNVSCPNTHVGEPFTTTPEALDRLFTALDKIDRPQ
PTLVKMPLNKPWGEYKELLDVLAEHNVQGLSIANLQKDRTGLEIPRDWEGGLSGGPCTNASTELIRKVYKEYGDRFAIAG
IGGVFTPEQAYAKIRSGSSLVMFISSLMYRGPQQITVLKRGLAQLLRRDGFEHVSDAVGVDVE

Sequences:

>Translated_383_residues
MTYVSESFWHDAVNKATTDLFTFGYKHIIKPNFVFNHRPDEAHDQMIEFCHVVKNVPPLLLAEQLMLDYTDPILETNVMG
VDFTNPFGLSAGLDKNCDMPVVLDHAGFGFETVGSTTSRPCSGNAKPWFHRLPEYDSMMVHVGLANIGSDKVIERAEKAW
TQARQMQLSVSIARTNDDQCGDLDEGIEDYCISMRRAVGRTAMVEVNVSCPNTHVGEPFTTTPEALDRLFTALDKIDRPQ
PTLVKMPLNKPWGEYKELLDVLAEHNVQGLSIANLQKDRTGLEIPRDWEGGLSGGPCTNASTELIRKVYKEYGDRFAIAG
IGGVFTPEQAYAKIRSGSSLVMFISSLMYRGPQQITVLKRGLAQLLRRDGFEHVSDAVGVDVE
>Mature_382_residues
TYVSESFWHDAVNKATTDLFTFGYKHIIKPNFVFNHRPDEAHDQMIEFCHVVKNVPPLLLAEQLMLDYTDPILETNVMGV
DFTNPFGLSAGLDKNCDMPVVLDHAGFGFETVGSTTSRPCSGNAKPWFHRLPEYDSMMVHVGLANIGSDKVIERAEKAWT
QARQMQLSVSIARTNDDQCGDLDEGIEDYCISMRRAVGRTAMVEVNVSCPNTHVGEPFTTTPEALDRLFTALDKIDRPQP
TLVKMPLNKPWGEYKELLDVLAEHNVQGLSIANLQKDRTGLEIPRDWEGGLSGGPCTNASTELIRKVYKEYGDRFAIAGI
GGVFTPEQAYAKIRSGSSLVMFISSLMYRGPQQITVLKRGLAQLLRRDGFEHVSDAVGVDVE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=361, Percent_Identity=32.6869806094183, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=31.9277108433735, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17509475, Length=324, Percent_Identity=31.7901234567901, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281361352, Length=323, Percent_Identity=29.7213622291022, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137316, Length=323, Percent_Identity=29.7213622291022, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 42647; Mature: 42516

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYVSESFWHDAVNKATTDLFTFGYKHIIKPNFVFNHRPDEAHDQMIEFCHVVKNVPPLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCHHH
LAEQLMLDYTDPILETNVMGVDFTNPFGLSAGLDKNCDMPVVLDHAGFGFETVGSTTSRP
HHHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHCCCCCCCC
CSGNAKPWFHRLPEYDSMMVHVGLANIGSDKVIERAEKAWTQARQMQLSVSIARTNDDQC
CCCCCCHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCC
GDLDEGIEDYCISMRRAVGRTAMVEVNVSCPNTHVGEPFTTTPEALDRLFTALDKIDRPQ
CCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PTLVKMPLNKPWGEYKELLDVLAEHNVQGLSIANLQKDRTGLEIPRDWEGGLSGGPCTNA
CCEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCHHCCCCCCCCCCCCCCCCCCCCCCC
STELIRKVYKEYGDRFAIAGIGGVFTPEQAYAKIRSGSSLVMFISSLMYRGPQQITVLKR
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
GLAQLLRRDGFEHVSDAVGVDVE
HHHHHHHHCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TYVSESFWHDAVNKATTDLFTFGYKHIIKPNFVFNHRPDEAHDQMIEFCHVVKNVPPLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCHHH
LAEQLMLDYTDPILETNVMGVDFTNPFGLSAGLDKNCDMPVVLDHAGFGFETVGSTTSRP
HHHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHCCCCCCCC
CSGNAKPWFHRLPEYDSMMVHVGLANIGSDKVIERAEKAWTQARQMQLSVSIARTNDDQC
CCCCCCHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCC
GDLDEGIEDYCISMRRAVGRTAMVEVNVSCPNTHVGEPFTTTPEALDRLFTALDKIDRPQ
CCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PTLVKMPLNKPWGEYKELLDVLAEHNVQGLSIANLQKDRTGLEIPRDWEGGLSGGPCTNA
CCEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCHHCCCCCCCCCCCCCCCCCCCCCCC
STELIRKVYKEYGDRFAIAGIGGVFTPEQAYAKIRSGSSLVMFISSLMYRGPQQITVLKR
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
GLAQLLRRDGFEHVSDAVGVDVE
HHHHHHHHCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA