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The map label for this gene is trxC [H]

Identifier: 213692933

GI number: 213692933

Start: 2294037

End: 2294408

Strand: Direct

Name: trxC [H]

Synonym: Blon_2077

Alternate gene names: 213692933

Gene position: 2294037-2294408 (Clockwise)

Preceding gene: 213692921

Following gene: 213692934

Centisome position: 80.98

GC content: 60.75

Gene sequence:

>372_bases
ATGGCCACCACCGCCATCACTTCAGCTGAGTTTGAGAAGACCATTACCGACAACGAAATCGTGTTCGTTGACTTCTGGGC
CACTTGGTGCGGTCCGTGCCGAGCATTCGGCCCGATTTTCGAGGCTGCGTCCAACGAGCCGGAGAATGCGAACATCGCTT
TCGTCAAGGTGGACATCGATGCCAATCAGGATCTGGCTCAGGCTGCCGGCATTCAGGCGGTGCCTACGCTGATGATTGCC
AAGCAGGGCGAGGTCATTTTCCAGCAGGCCGGCGCGCTGCAGGCCTCCGATCTGGACGACCTCATCGCCCAGGCCAAGGC
GCTGGATCTGGCCGCCGCCAAAGCGCAGCAGGCAGCGCAGGAGCAGCAGTAA

Upstream 100 bases:

>100_bases
CAATCCATTCAGCTTGGGGCACAAACTTTTGCCGAAATGTTGGGTGGTGCTGGGAAACTGGTATACAGCATCAAGCACTG
TGTTTGAGGAAGGAACTTCA

Downstream 100 bases:

>100_bases
GCCTTATCACGCTGCGGCAGCGGAAGCACGGAAAAAGACCATATATAGCGCTTCCTTGCACTGCTAGCTACTACATATGC
CATCCGTGGCGGGTCGAACA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MATTAITSAEFEKTITDNEIVFVDFWATWCGPCRAFGPIFEAASNEPENANIAFVKVDIDANQDLAQAAGIQAVPTLMIA
KQGEVIFQQAGALQASDLDDLIAQAKALDLAAAKAQQAAQEQQ

Sequences:

>Translated_123_residues
MATTAITSAEFEKTITDNEIVFVDFWATWCGPCRAFGPIFEAASNEPENANIAFVKVDIDANQDLAQAAGIQAVPTLMIA
KQGEVIFQQAGALQASDLDDLIAQAKALDLAAAKAQQAAQEQQ
>Mature_122_residues
ATTAITSAEFEKTITDNEIVFVDFWATWCGPCRAFGPIFEAASNEPENANIAFVKVDIDANQDLAQAAGIQAVPTLMIAK
QGEVIFQQAGALQASDLDDLIAQAKALDLAAAKAQQAAQEQQ

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI50592994, Length=75, Percent_Identity=37.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI148727319, Length=103, Percent_Identity=33.9805825242718, Blast_Score=63, Evalue=5e-11,
Organism=Homo sapiens, GI42516570, Length=103, Percent_Identity=33.9805825242718, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI1788936, Length=99, Percent_Identity=38.3838383838384, Blast_Score=86, Evalue=7e-19,
Organism=Escherichia coli, GI87082331, Length=82, Percent_Identity=37.8048780487805, Blast_Score=71, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=91, Percent_Identity=41.7582417582418, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=32.9545454545455, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=88, Percent_Identity=32.9545454545455, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=79, Percent_Identity=40.5063291139241, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=72, Percent_Identity=40.2777777777778, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=83, Percent_Identity=39.7590361445783, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532254, Length=83, Percent_Identity=39.7590361445783, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=92, Percent_Identity=39.1304347826087, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=93, Percent_Identity=35.4838709677419, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320303, Length=75, Percent_Identity=34.6666666666667, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=33.6842105263158, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=89, Percent_Identity=34.8314606741573, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=36.9047619047619, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=36.9047619047619, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13072; Mature: 12940

Theoretical pI: Translated: 3.77; Mature: 3.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTAITSAEFEKTITDNEIVFVDFWATWCGPCRAFGPIFEAASNEPENANIAFVKVDID
CCCCCCCCHHHHHCCCCCCEEEEEEHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEC
ANQDLAQAAGIQAVPTLMIAKQGEVIFQQAGALQASDLDDLIAQAKALDLAAAKAQQAAQ
CCCCHHHHCCCCHHHHHEEECCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQQ
CCC
>Mature Secondary Structure 
ATTAITSAEFEKTITDNEIVFVDFWATWCGPCRAFGPIFEAASNEPENANIAFVKVDID
CCCCCCCHHHHHCCCCCCEEEEEEHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEC
ANQDLAQAAGIQAVPTLMIAKQGEVIFQQAGALQASDLDDLIAQAKALDLAAAKAQQAAQ
CCCCHHHHCCCCHHHHHEEECCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]