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The map label for this gene is adhB [H]

Identifier: 213692779

GI number: 213692779

Start: 2092797

End: 2093840

Strand: Reverse

Name: adhB [H]

Synonym: Blon_1915

Alternate gene names: 213692779

Gene position: 2093840-2092797 (Counterclockwise)

Preceding gene: 213692783

Following gene: 213692777

Centisome position: 73.92

GC content: 62.36

Gene sequence:

>1044_bases
ATGACCGAAATGATGAAAGCCGCGATTTTCGTGGAGCCTGGCAAGATGGCCGTGGAAGAAGTGCCGAAGGCGACGCGTGA
ACAGGATGATGACATCGTGATCCGCGTGGTGCGCACGTGCGTGTGTGGCTCTGATTTGTGGTTCTTCCGTGGGCTGAGCG
GACAGGCCGCGCACAGCCAGGTGGGTCACGAGTCCATCGGTGTGGTCGAAGAGGTTGGCGCGGCGGTCGAATCCGTTAAG
CCAGGTGATTTCGTGGTCGTGCCATTCCCGTACAGCTGCGGCAAGTGCCCGGTATGCAAGGCCGGCTTCGAATCCGTGTG
CCCGCACGGCGGCTACTTCTCCGCTTGTCAGGCTGAATACCTGCGTGTGCCCGAGGCGGACGGCACCGTGGTCAAGGTGC
CCGGTTCACCGGAAGATTATTCCGATGAGCAGCTCGCATCGCTGCTGACCATTTCCGATGTGATGTCCACCGGTTATCAC
GCGGCGGCTTCTGCCGAGGTCAAGCCCGGTGACACCGCCGTGGTCATGGGCGATGGTGCAGTCGGCCTGTGCGGTGTGAT
TGCCGCTAAGATGCTCGGTGCGAAACGCATCATCGCCATGAGCCGTCACGAGGATCGCGCGGCGCTCGCCCGCGAATTTG
GTGCGACTGATATCGTGCCCGAGCGCGGCCAAGAAGCTATTGACAAGGTGCTAGGAATGACCGGCGGTTACGGTGCCGAC
GCAGTTCTCGAATGCGTGGGCTCCAAGCAGTCCTTCGACACGGCGATTGGCCTGATTCGCCGCGGTGGCGTGATCGGCCG
TGTGGGCCTGCCGCATGACGTGGAGATCAGCGCCGAAGGCACGTTCTACGGCAACATCGGCATCAAGGGCGGCCCGGCCC
CCGTGCGCCACTACGACCTTGACTGCGGACTGCTCGACGCGGTGCTCAAGGGCGAAATCAACCCCGGCCGCGTGTTCACC
GACGAATACGACCTCGACCATATCCAAGACGCCTACGAGGCGATGGACCAGCGCAAGGTCATCAAGGCGCTGATCCGGTT
CTAG

Upstream 100 bases:

>100_bases
GAAGAAAACCGGAACATCATCGAACAGGTGAAGCGCCTGCAAACCGACGTCAAACAATAAACGACAATAGACAGATATTC
CCAACAAAGGAGTGATGGAC

Downstream 100 bases:

>100_bases
GGTTAGGTACGCAGCGAACGGTTCTCACCAAGAACCGTGTGAGCCATTCGCACAAAATCGCACAATCAAACAGGCCGACG
GTGTGATGGGGGGTGTTCCT

Product: Alcohol dehydrogenase GroES domain protein

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTEMMKAAIFVEPGKMAVEEVPKATREQDDDIVIRVVRTCVCGSDLWFFRGLSGQAAHSQVGHESIGVVEEVGAAVESVK
PGDFVVVPFPYSCGKCPVCKAGFESVCPHGGYFSACQAEYLRVPEADGTVVKVPGSPEDYSDEQLASLLTISDVMSTGYH
AAASAEVKPGDTAVVMGDGAVGLCGVIAAKMLGAKRIIAMSRHEDRAALAREFGATDIVPERGQEAIDKVLGMTGGYGAD
AVLECVGSKQSFDTAIGLIRRGGVIGRVGLPHDVEISAEGTFYGNIGIKGGPAPVRHYDLDCGLLDAVLKGEINPGRVFT
DEYDLDHIQDAYEAMDQRKVIKALIRF

Sequences:

>Translated_347_residues
MTEMMKAAIFVEPGKMAVEEVPKATREQDDDIVIRVVRTCVCGSDLWFFRGLSGQAAHSQVGHESIGVVEEVGAAVESVK
PGDFVVVPFPYSCGKCPVCKAGFESVCPHGGYFSACQAEYLRVPEADGTVVKVPGSPEDYSDEQLASLLTISDVMSTGYH
AAASAEVKPGDTAVVMGDGAVGLCGVIAAKMLGAKRIIAMSRHEDRAALAREFGATDIVPERGQEAIDKVLGMTGGYGAD
AVLECVGSKQSFDTAIGLIRRGGVIGRVGLPHDVEISAEGTFYGNIGIKGGPAPVRHYDLDCGLLDAVLKGEINPGRVFT
DEYDLDHIQDAYEAMDQRKVIKALIRF
>Mature_346_residues
TEMMKAAIFVEPGKMAVEEVPKATREQDDDIVIRVVRTCVCGSDLWFFRGLSGQAAHSQVGHESIGVVEEVGAAVESVKP
GDFVVVPFPYSCGKCPVCKAGFESVCPHGGYFSACQAEYLRVPEADGTVVKVPGSPEDYSDEQLASLLTISDVMSTGYHA
AASAEVKPGDTAVVMGDGAVGLCGVIAAKMLGAKRIIAMSRHEDRAALAREFGATDIVPERGQEAIDKVLGMTGGYGADA
VLECVGSKQSFDTAIGLIRRGGVIGRVGLPHDVEISAEGTFYGNIGIKGGPAPVRHYDLDCGLLDAVLKGEINPGRVFTD
EYDLDHIQDAYEAMDQRKVIKALIRF

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=393, Percent_Identity=27.2264631043257, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=28.8409703504043, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565154, Length=391, Percent_Identity=27.8772378516624, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=29.041095890411, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71743840, Length=384, Percent_Identity=25.2604166666667, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073058, Length=384, Percent_Identity=25.2604166666667, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156627571, Length=273, Percent_Identity=26.7399267399267, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=389, Percent_Identity=28.5347043701799, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788073, Length=359, Percent_Identity=28.9693593314763, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=29.6, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=26.969696969697, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788075, Length=346, Percent_Identity=26.0115606936416, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787863, Length=357, Percent_Identity=25.4901960784314, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI226510992, Length=332, Percent_Identity=27.4096385542169, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082125, Length=335, Percent_Identity=26.2686567164179, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081918, Length=235, Percent_Identity=33.6170212765957, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=315, Percent_Identity=24.1269841269841, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=23.546511627907, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=25.9052924791086, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=272, Percent_Identity=24.6323529411765, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=26.2734584450402, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=358, Percent_Identity=25.9776536312849, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=287, Percent_Identity=26.4808362369338, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=293, Percent_Identity=31.740614334471, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=293, Percent_Identity=31.740614334471, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=345, Percent_Identity=26.3768115942029, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=27.3458445040214, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=311, Percent_Identity=27.9742765273312, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=274, Percent_Identity=28.4671532846715, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=282, Percent_Identity=27.6595744680851, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=290, Percent_Identity=26.551724137931, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=26.6846361185984, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17137530, Length=317, Percent_Identity=27.1293375394322, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=322, Percent_Identity=27.0186335403727, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221457811, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550770, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551930, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 36818; Mature: 36687

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMMKAAIFVEPGKMAVEEVPKATREQDDDIVIRVVRTCVCGSDLWFFRGLSGQAAHSQ
CCCHHEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHH
VGHESIGVVEEVGAAVESVKPGDFVVVPFPYSCGKCPVCKAGFESVCPHGGYFSACQAEY
CCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHH
LRVPEADGTVVKVPGSPEDYSDEQLASLLTISDVMSTGYHAAASAEVKPGDTAVVMGDGA
HCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
VGLCGVIAAKMLGAKRIIAMSRHEDRAALAREFGATDIVPERGQEAIDKVLGMTGGYGAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHH
AVLECVGSKQSFDTAIGLIRRGGVIGRVGLPHDVEISAEGTFYGNIGIKGGPAPVRHYDL
HHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCEEEECCCCCCCCCCCEEECC
DCGLLDAVLKGEINPGRVFTDEYDLDHIQDAYEAMDQRKVIKALIRF
CHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEMMKAAIFVEPGKMAVEEVPKATREQDDDIVIRVVRTCVCGSDLWFFRGLSGQAAHSQ
CCHHEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHH
VGHESIGVVEEVGAAVESVKPGDFVVVPFPYSCGKCPVCKAGFESVCPHGGYFSACQAEY
CCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHH
LRVPEADGTVVKVPGSPEDYSDEQLASLLTISDVMSTGYHAAASAEVKPGDTAVVMGDGA
HCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
VGLCGVIAAKMLGAKRIIAMSRHEDRAALAREFGATDIVPERGQEAIDKVLGMTGGYGAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHH
AVLECVGSKQSFDTAIGLIRRGGVIGRVGLPHDVEISAEGTFYGNIGIKGGPAPVRHYDL
HHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEECCEEEECCCCCCCCCCCEEECC
DCGLLDAVLKGEINPGRVFTDEYDLDHIQDAYEAMDQRKVIKALIRF
CHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]