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The map label for this gene is argH [H]

Identifier: 213692740

GI number: 213692740

Start: 2042446

End: 2043918

Strand: Reverse

Name: argH [H]

Synonym: Blon_1874

Alternate gene names: 213692740

Gene position: 2043918-2042446 (Counterclockwise)

Preceding gene: 213692741

Following gene: 213692739

Centisome position: 72.15

GC content: 65.99

Gene sequence:

>1473_bases
ATGACTGAGAACAACGAACATCTGGCCCTGTGGGGTGGTCGCTTTACGTCCGGTCCGTCGCCGGAATTGGCCCGACTGTC
CAAGTCCACGCAGTTCGACTGGCGCTTGGCCGACGACGATATCGCCGGTTCCCGCGCCCACGCCCGTGCTCTCGGCCGTG
CGGGACTTTTGACCGCCGACGAGCTGCAGCGCATGGAGGATGCGCTCGACACGCTCCAGCGTCATGTGGATGACGGCTCC
TTCGCCCCCATCGAAGACGATGAGGACGAGGCCACCGCCCTCGAACGCGGTCTGATTGACATTGCCGGCGACGAACTCGG
CGGCAAACTGCGTGCCGGACGCTCCCGCAACGACCAGATCGCCTGCCTGATTCGTATGTGGCTGCGCCGCCACTCCCGTG
CGATTGCCGGACTCCTGCTTGACCTCGTCAACGCCCTGATCGAGCAGAGCGAAAAGGCCGGCCGCACCGTGATGCCGGGC
CGCACCCACATGCAGCACGCCCAGCCCGTGCTGCTCGCGCACCAGCTCATGGCCCACGCTTGGCCGCTGATCCGCGACGT
GCAGCGACTGATCGACTGGGACAAGCGCATCAACGCCTCCCCGTACGGCTCCGGCGCGCTGGCCGGCAACACGCTCGGCC
TGGACCCGGAGGCCGTGGCGCGTGAGCTCGGCTTCTCCCGCGTGACCGACAACTCCATCGATGGCACCGCCGCACGTGAT
CTCGTCGCCGAATTCGCGTTCGTGGCCGCCATGACCGGCGTGGACATCTCCCGCCTGTCCGAGGAGATCATCATCTGGAA
CACCCAGGAGTTCGCCTTCGTCAAGCTCGACGACGGCTATTCCACCGGCTCCTCCATCATGCCGCAGAAGAAGAACCCGG
ATATCGCCGAGCTCGCCCGCGGCAAGTCCGGCCGACTCATCGGCGATCTGACCGGTCTGCTGTCCACCCTGAAGGGCCTG
CCCACCGCCTACGCTCGCGATCTGCAGGAAGACAAGGAGGCCGTGTTCGACCAGGTCGATACGCTCGAAGTGCTGCTGCC
CGCCTTCACCGGCATGGTCAAGACCATGCACTTCGACGGCGACCGCCTGGAAGAGGAAGCTCCGACCGGCTTCGCGCTGG
CCACCGACATCGCCGAATGGCTCGTCAAGAACGGTGTGCCGTTCCGCCACGCGCACGAGCTCTCTGGTGCCTGCGTCAAG
CTCGCCGAAGGCCGCGGCCAGGAACTGTGGGATCTGACCGACAATGACTTCATCGAGACCTTCGCCGCGTTCCTGCCGGC
CGACAAGGCTCCGGGAGTACGCGAAGTGCTCTCCAGCCACGGTTCGGTCGACTCCCGCAACGGCAAGGGCGGCACCGCTT
ACGGTCGCGTGCGCGAGCAGATCGCCGACGCCAAGGCCGAGGTCGAAGAACTCAAGCTCTTCCCCGCATCCACGTCGGAT
GGCTCCGCCTACAAAGCCCCCGGCACGTTCTAG

Upstream 100 bases:

>100_bases
GTCACACTCCATGTGACAGCCCTCGCCAGCGGGGGCAACTGTATGTTTGAACACATTGCTACGCTTAAACACAGCTATTT
TCACTTTTCAAGGAGCCTTC

Downstream 100 bases:

>100_bases
TCCCAATAGAGCTCCCTCGTCAGAGGGAGCTCTATTTTGCTGTTGTCACTGCAACGGCATACACTGAGAAATCGTAACGA
ACGGGAGCCGTGAGGCTGAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTADELQRMEDALDTLQRHVDDGS
FAPIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQIACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPG
RTHMQHAQPVLLAHQLMAHAWPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARD
LVAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELARGKSGRLIGDLTGLLSTLKGL
PTAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDGDRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVK
LAEGRGQELWDLTDNDFIETFAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSD
GSAYKAPGTF

Sequences:

>Translated_490_residues
MTENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTADELQRMEDALDTLQRHVDDGS
FAPIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQIACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPG
RTHMQHAQPVLLAHQLMAHAWPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARD
LVAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELARGKSGRLIGDLTGLLSTLKGL
PTAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDGDRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVK
LAEGRGQELWDLTDNDFIETFAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSD
GSAYKAPGTF
>Mature_489_residues
TENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTADELQRMEDALDTLQRHVDDGSF
APIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQIACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPGR
THMQHAQPVLLAHQLMAHAWPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARDL
VAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELARGKSGRLIGDLTGLLSTLKGLP
TAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDGDRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVKL
AEGRGQELWDLTDNDFIETFAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSDG
SAYKAPGTF

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=42.6086956521739, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=42.6086956521739, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=40.0437636761488, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=40.2173913043478, Blast_Score=325, Evalue=8e-89,
Organism=Escherichia coli, GI1790398, Length=462, Percent_Identity=42.2077922077922, Blast_Score=328, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=39.6103896103896, Blast_Score=322, Evalue=6e-89,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=41.8141592920354, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=41.8141592920354, Blast_Score=342, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53352; Mature: 53221

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTAD
CCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCHH
ELQRMEDALDTLQRHVDDGSFAPIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHCCCCHHCCCHHCCCCCCCHH
ACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPGRTHMQHAQPVLLAHQLMAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
WPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCCCCCCHHHHH
LVAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELAR
HHHHHHHHHHHHCCCHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHC
GKSGRLIGDLTGLLSTLKGLPTAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDG
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVKLAEGRGQELWDLTDNDFIET
HHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHH
FAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSD
HHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC
GSAYKAPGTF
CCCCCCCCCC
>Mature Secondary Structure 
TENNEHLALWGGRFTSGPSPELARLSKSTQFDWRLADDDIAGSRAHARALGRAGLLTAD
CCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCHH
ELQRMEDALDTLQRHVDDGSFAPIEDDEDEATALERGLIDIAGDELGGKLRAGRSRNDQI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHCCCCHHCCCHHCCCCCCCHH
ACLIRMWLRRHSRAIAGLLLDLVNALIEQSEKAGRTVMPGRTHMQHAQPVLLAHQLMAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
WPLIRDVQRLIDWDKRINASPYGSGALAGNTLGLDPEAVARELGFSRVTDNSIDGTAARD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCCCCCCHHHHH
LVAEFAFVAAMTGVDISRLSEEIIIWNTQEFAFVKLDDGYSTGSSIMPQKKNPDIAELAR
HHHHHHHHHHHHCCCHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHC
GKSGRLIGDLTGLLSTLKGLPTAYARDLQEDKEAVFDQVDTLEVLLPAFTGMVKTMHFDG
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRLEEEAPTGFALATDIAEWLVKNGVPFRHAHELSGACVKLAEGRGQELWDLTDNDFIET
HHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHH
FAAFLPADKAPGVREVLSSHGSVDSRNGKGGTAYGRVREQIADAKAEVEELKLFPASTSD
HHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC
GSAYKAPGTF
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA