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The map label for this gene is uvrA [H]

Identifier: 213692553

GI number: 213692553

Start: 1837604

End: 1839847

Strand: Reverse

Name: uvrA [H]

Synonym: Blon_1685

Alternate gene names: 213692553

Gene position: 1839847-1837604 (Counterclockwise)

Preceding gene: 213692554

Following gene: 213692549

Centisome position: 64.95

GC content: 52.05

Gene sequence:

>2244_bases
ATGGCAGACATTATGGTGCATGGGCTTACCCAGAATAACTTGAAACACGTCACATTCAGAATCCCGAAGGAAAAAATCAC
AGTATTTACCGGGGTGTCCGGGTCCGGGAAATCCAGTATTGTCTTTGACACGATTGCAGCGGAATCCCAGCGGCAGATGA
ACTTAACCTACCCGGCATTTGTGCGGTCCAGGCTTCCCAAATACCCCAGACCGGCAGTGGAGCGCATTGACAATCTGACA
CCGTCCGTTGTGGTGGACCAGTCCTCCTTAGGGGGAAATGCACGCTCCACAGTAGGGACCATCAGCGGACTGTATGCCAG
CCTGCGGCTGTTGTTTTCCAGGATTGGGCAGCCCTTTGTGGGAACTGCGTCTTATTTCTCTTTTAATGACCCCAACGGGA
TGTGCAAGACCTGTTCCGGTCTCGGGAAAGTTACAAAAGTGGATATGGAAGCAGTCCTGGACCGGAATAAATCCTGGAAC
CAGGGCTGTGTGAAGGATTCCCTGTACCGTCCAGGATCCTGGTATTGGAAGCAGTATGCTGAGTCAGGGCTGTTCGACCT
TGATAAACCCATCCGGGATTACACAAAAGAGGAATACAACCTTCTTGTCTATGGTGCCCGTGATGGTAGGGGAGAGCCGG
AGAACCCGAAAGTAACTGGACTGTACCATAAGTATACGAAGGCCCTCTTAAACCGGGATATCAGCAGCAAAAGCAGACAC
ACCAAAGAGAAGTCAAAAAAGCTGATTACGGAAATAGAATGTAGCGACTGTCATGGAAGAAGGCTGAATGAGGCGGCTTT
GAACTGTAGAATAAACGGGTATTCTATTGCAGACATGTGCGAGATGGAGCTGACTCTCCTGCGGGAAGTCCTGACACAGA
TCACGGACCAGACAGTGGGTCTGCTGGTTCATACCATCCTGGAGGGATTGGACCGGATGATCGAGATTGGACTCCCTTAT
CTGCATCTGAACCGGGAAACACCCTCCTTGTCCGGCGGGGAGGCCCAGAGGCTGAAGCTGGTCCGGTATATGGGAAGCAG
CCTGACCGGGATGACCTACATCTTTGACGAACCCAGTGCCGGGATGCATCCACGGGATGTCTACCGTATGAATCATCTTC
TCAAGAAGCTTCGGGATAAAGGAAATACAGTCCTTGTGGTGGAACACGATAAAGACGTAATCTCCATTGCAGACCATGTC
ATTGACGTGGGGCCTGCGGCAGGACAAAACGGCGGTGAAGTCGTGTTTGAGGGAAGCTATCCGGAACTACTTAGGGCAGA
TACCCTGACGGGAAAATCCATGCAAAAGTTGTTCCCCATAAAACATACGCCACGTAAAGCCACGGGCAGCCTGCCGGTAA
GGGATGCCTGCCTTCATAACCTAAAGCATGTGGATGTGGACATCCCTCTGGGAGTCATGACGGTGGTGACTGGTGTGGCT
GGTTCGGGAAAGAGTACCCTCATTTCCCAGGTATTTGCGAGAGCATATGAGAATGAAGTGGTGATGGTGGACCAGGGGCC
GATTACAGCTACCAGCCGCTCTACACCAGCTTCCTACCTGGGCTTCTTTGATGAGATACGAAAACTTCTGGCACGGGAGA
ACAATCAGCCGGAAAGCCTGTTCAGTTTTAATTCCGCCGGAGCCTGCCCAATCTGCGGCGGCAAAGGTGTTCTCGTTACG
GAACTTGCCTTTATGGACCCGATTGTTACAGAATGCGAGGCATGCGGCGGTGTGCGGTATAACAGGGAGGCCCTTGCCTG
TACCTACAAGGGGAGGAATATTGTCCAATTGCTGGGGCTTACCGCTTCCCAGGCACTGGAATTATTTGAGGATACCAGGA
TCAGGAAACGCCTGAGCGTAATGCAGCAGGTGGGATTATCCTATCTGCCGCTGGGGCAGCCCCTTAGCACCCTGTCCGGG
GGAGAGCGGCAGCGGATTAAGCTGGCAAAGAACCTGGGGAAGAGCAGTAGCATCATTGTCATGGATGAGCCGACCACAGG
CCTTCACAGGTCCGATGTAGATAATTTGTTGAATCTGTTTGATGGGATTGTATCCAGCGGAAATACGCTGGTAGTGATTG
AGCATAACCTGGACGTGATGAAGCAGGCGGACTGGATTATTGACATCGGCCCCGATGGAGGGAAGAACGGGGGAGAAGTG
GTATTTACAGGGACACCGGAGGAGATGCTTCAAAATGCAAAGACACTGACAGCGGACTGTCTGCGTGCATCCAGTATTTC
ATAG

Upstream 100 bases:

>100_bases
ATTCTGTACGCAGGTCCCACCGCAGACATCCTTACGGCTCTGATTGCAGCAGGTTTGGTTGGATATGACAGCAGGAAAAA
GAGAAAAGGAGTGTGATCAT

Downstream 100 bases:

>100_bases
GCGAATTCCTGTTCTCCCTGCTCCTGATTAGAAAATTAAGGGTTATAGGCCAAAATGTGTGTCCGGCGCTCGAGTCGTTC
GTCGGTCATCGCGTTGGCCG

Product: ABC transporter

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MADIMVHGLTQNNLKHVTFRIPKEKITVFTGVSGSGKSSIVFDTIAAESQRQMNLTYPAFVRSRLPKYPRPAVERIDNLT
PSVVVDQSSLGGNARSTVGTISGLYASLRLLFSRIGQPFVGTASYFSFNDPNGMCKTCSGLGKVTKVDMEAVLDRNKSWN
QGCVKDSLYRPGSWYWKQYAESGLFDLDKPIRDYTKEEYNLLVYGARDGRGEPENPKVTGLYHKYTKALLNRDISSKSRH
TKEKSKKLITEIECSDCHGRRLNEAALNCRINGYSIADMCEMELTLLREVLTQITDQTVGLLVHTILEGLDRMIEIGLPY
LHLNRETPSLSGGEAQRLKLVRYMGSSLTGMTYIFDEPSAGMHPRDVYRMNHLLKKLRDKGNTVLVVEHDKDVISIADHV
IDVGPAAGQNGGEVVFEGSYPELLRADTLTGKSMQKLFPIKHTPRKATGSLPVRDACLHNLKHVDVDIPLGVMTVVTGVA
GSGKSTLISQVFARAYENEVVMVDQGPITATSRSTPASYLGFFDEIRKLLARENNQPESLFSFNSAGACPICGGKGVLVT
ELAFMDPIVTECEACGGVRYNREALACTYKGRNIVQLLGLTASQALELFEDTRIRKRLSVMQQVGLSYLPLGQPLSTLSG
GERQRIKLAKNLGKSSSIIVMDEPTTGLHRSDVDNLLNLFDGIVSSGNTLVVIEHNLDVMKQADWIIDIGPDGGKNGGEV
VFTGTPEEMLQNAKTLTADCLRASSIS

Sequences:

>Translated_747_residues
MADIMVHGLTQNNLKHVTFRIPKEKITVFTGVSGSGKSSIVFDTIAAESQRQMNLTYPAFVRSRLPKYPRPAVERIDNLT
PSVVVDQSSLGGNARSTVGTISGLYASLRLLFSRIGQPFVGTASYFSFNDPNGMCKTCSGLGKVTKVDMEAVLDRNKSWN
QGCVKDSLYRPGSWYWKQYAESGLFDLDKPIRDYTKEEYNLLVYGARDGRGEPENPKVTGLYHKYTKALLNRDISSKSRH
TKEKSKKLITEIECSDCHGRRLNEAALNCRINGYSIADMCEMELTLLREVLTQITDQTVGLLVHTILEGLDRMIEIGLPY
LHLNRETPSLSGGEAQRLKLVRYMGSSLTGMTYIFDEPSAGMHPRDVYRMNHLLKKLRDKGNTVLVVEHDKDVISIADHV
IDVGPAAGQNGGEVVFEGSYPELLRADTLTGKSMQKLFPIKHTPRKATGSLPVRDACLHNLKHVDVDIPLGVMTVVTGVA
GSGKSTLISQVFARAYENEVVMVDQGPITATSRSTPASYLGFFDEIRKLLARENNQPESLFSFNSAGACPICGGKGVLVT
ELAFMDPIVTECEACGGVRYNREALACTYKGRNIVQLLGLTASQALELFEDTRIRKRLSVMQQVGLSYLPLGQPLSTLSG
GERQRIKLAKNLGKSSSIIVMDEPTTGLHRSDVDNLLNLFDGIVSSGNTLVVIEHNLDVMKQADWIIDIGPDGGKNGGEV
VFTGTPEEMLQNAKTLTADCLRASSIS
>Mature_746_residues
ADIMVHGLTQNNLKHVTFRIPKEKITVFTGVSGSGKSSIVFDTIAAESQRQMNLTYPAFVRSRLPKYPRPAVERIDNLTP
SVVVDQSSLGGNARSTVGTISGLYASLRLLFSRIGQPFVGTASYFSFNDPNGMCKTCSGLGKVTKVDMEAVLDRNKSWNQ
GCVKDSLYRPGSWYWKQYAESGLFDLDKPIRDYTKEEYNLLVYGARDGRGEPENPKVTGLYHKYTKALLNRDISSKSRHT
KEKSKKLITEIECSDCHGRRLNEAALNCRINGYSIADMCEMELTLLREVLTQITDQTVGLLVHTILEGLDRMIEIGLPYL
HLNRETPSLSGGEAQRLKLVRYMGSSLTGMTYIFDEPSAGMHPRDVYRMNHLLKKLRDKGNTVLVVEHDKDVISIADHVI
DVGPAAGQNGGEVVFEGSYPELLRADTLTGKSMQKLFPIKHTPRKATGSLPVRDACLHNLKHVDVDIPLGVMTVVTGVAG
SGKSTLISQVFARAYENEVVMVDQGPITATSRSTPASYLGFFDEIRKLLARENNQPESLFSFNSAGACPICGGKGVLVTE
LAFMDPIVTECEACGGVRYNREALACTYKGRNIVQLLGLTASQALELFEDTRIRKRLSVMQQVGLSYLPLGQPLSTLSGG
ERQRIKLAKNLGKSSSIIVMDEPTTGLHRSDVDNLLNLFDGIVSSGNTLVVIEHNLDVMKQADWIIDIGPDGGKNGGEVV
FTGTPEEMLQNAKTLTADCLRASSIS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=676, Percent_Identity=36.6863905325444, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82072; Mature: 81941

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIMVHGLTQNNLKHVTFRIPKEKITVFTGVSGSGKSSIVFDTIAAESQRQMNLTYPAF
CCCEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEHHCCCCCCCCCCHHHH
VRSRLPKYPRPAVERIDNLTPSVVVDQSSLGGNARSTVGTISGLYASLRLLFSRIGQPFV
HHHHCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GTASYFSFNDPNGMCKTCSGLGKVTKVDMEAVLDRNKSWNQGCVKDSLYRPGSWYWKQYA
CCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHH
ESGLFDLDKPIRDYTKEEYNLLVYGARDGRGEPENPKVTGLYHKYTKALLNRDISSKSRH
HCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHH
TKEKSKKLITEIECSDCHGRRLNEAALNCRINGYSIADMCEMELTLLREVLTQITDQTVG
HHHHHHHHHHEECCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLVHTILEGLDRMIEIGLPYLHLNRETPSLSGGEAQRLKLVRYMGSSLTGMTYIFDEPSA
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
GMHPRDVYRMNHLLKKLRDKGNTVLVVEHDKDVISIADHVIDVGPAAGQNGGEVVFEGSY
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEECCCC
PELLRADTLTGKSMQKLFPIKHTPRKATGSLPVRDACLHNLKHVDVDIPLGVMTVVTGVA
HHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHCCC
GSGKSTLISQVFARAYENEVVMVDQGPITATSRSTPASYLGFFDEIRKLLARENNQPESL
CCCHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
FSFNSAGACPICGGKGVLVTELAFMDPIVTECEACGGVRYNREALACTYKGRNIVQLLGL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCHHHHHC
TASQALELFEDTRIRKRLSVMQQVGLSYLPLGQPLSTLSGGERQRIKLAKNLGKSSSIIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEE
MDEPTTGLHRSDVDNLLNLFDGIVSSGNTLVVIEHNLDVMKQADWIIDIGPDGGKNGGEV
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCEEEEECCCCCCCCCEE
VFTGTPEEMLQNAKTLTADCLRASSIS
EEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADIMVHGLTQNNLKHVTFRIPKEKITVFTGVSGSGKSSIVFDTIAAESQRQMNLTYPAF
CCEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEHHCCCCCCCCCCHHHH
VRSRLPKYPRPAVERIDNLTPSVVVDQSSLGGNARSTVGTISGLYASLRLLFSRIGQPFV
HHHHCCCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GTASYFSFNDPNGMCKTCSGLGKVTKVDMEAVLDRNKSWNQGCVKDSLYRPGSWYWKQYA
CCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHH
ESGLFDLDKPIRDYTKEEYNLLVYGARDGRGEPENPKVTGLYHKYTKALLNRDISSKSRH
HCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHH
TKEKSKKLITEIECSDCHGRRLNEAALNCRINGYSIADMCEMELTLLREVLTQITDQTVG
HHHHHHHHHHEECCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLVHTILEGLDRMIEIGLPYLHLNRETPSLSGGEAQRLKLVRYMGSSLTGMTYIFDEPSA
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
GMHPRDVYRMNHLLKKLRDKGNTVLVVEHDKDVISIADHVIDVGPAAGQNGGEVVFEGSY
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEECCCC
PELLRADTLTGKSMQKLFPIKHTPRKATGSLPVRDACLHNLKHVDVDIPLGVMTVVTGVA
HHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHCCC
GSGKSTLISQVFARAYENEVVMVDQGPITATSRSTPASYLGFFDEIRKLLARENNQPESL
CCCHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
FSFNSAGACPICGGKGVLVTELAFMDPIVTECEACGGVRYNREALACTYKGRNIVQLLGL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCHHHHHC
TASQALELFEDTRIRKRLSVMQQVGLSYLPLGQPLSTLSGGERQRIKLAKNLGKSSSIIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEE
MDEPTTGLHRSDVDNLLNLFDGIVSSGNTLVVIEHNLDVMKQADWIIDIGPDGGKNGGEV
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCEEEEECCCCCCCCCEE
VFTGTPEEMLQNAKTLTADCLRASSIS
EEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]