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The map label for this gene is mepA [H]

Identifier: 213692554

GI number: 213692554

Start: 1839852

End: 1841234

Strand: Reverse

Name: mepA [H]

Synonym: Blon_1686

Alternate gene names: 213692554

Gene position: 1841234-1839852 (Counterclockwise)

Preceding gene: 213692557

Following gene: 213692553

Centisome position: 65.0

GC content: 49.6

Gene sequence:

>1383_bases
ATGGACAAGACTATTAAAACAGTGAGGGGAAACCCTCTTGCAGCCGAACCTCTCGGCAGGCTGCTCATAAAATTTGCAAT
CCCATCTGTCTTATCCATGCTGGTGGATGCACTTTACAACATCGTAGACCAGATATTCATTGGGCGTGGGGTGGGATATC
TTGGCATTGCTGCAACCACGGTTACTTTTCCTTTCGTCACGATTCTTTTATCCATCGCCACCCTGCTGGGGATTGGCGGC
AGTGTCTATACGTCCATGAACTTAGGGGCAGGAAAAGAAGCAGAAGCCGAAAAAACCCTTGGAACGGTATTCACTCTGTC
TGTTGCCATAGGTATTCTGTTCACCGTTATATGCCTTACTTTCCTGAAACCGCTGGCACTAGCTTTTGGGGCTACAAAGG
GGGCGCAGGGCTCACTGTCCTATGTGCTGGATTATGCCCCCATCATTTTACTTGGGGCACCCTTTAGTATGGCAGCTATT
GCCCTGTCCAGTATGGCCAGAGCGTGTGGCAGCCCCATCCTGGCTATGGGATGCTTCCTGGTCGGAGCGGTAATCAACCT
GGTTTTGGATCCAATCTATATATTTGTTTTTAACTGGGGAGTGAAAGGTGCAGCAATCGCTACCGTAACCTCGCAGATCA
TGTCCGCGGTCATACTGTTGGTTTACTTTTTAAAGAAAGGGCATATCCGGCTAAGAAAAAAAAATATCTGCCCTACATTA
CCCATCTGCGGTCAGATATTTGCGTTTGGGCTTCCATCCTGCATGATTCAGGTGGCGGCAGCAATTCTGCAGATTGAACT
GAACAAAGCGGTGGTGAGCTGTGAAATGGCAGGCGTTGGCAGCGAAGCGGCACTTAGCAGTCTTGGGATTGTGCTTCGGA
TCAGTTCTGTAGTGGTTTCTATCTGTGTGGGGATTGCACTTGGGATGCAGCCCATCATCGGATTTAACAAAGGCGCTGGT
TTCGAACACCGGGTCAAAGAAACCTATAAAAAGGCGGTTGGCGCAGCTACGGTGGTTTCTGTGATTGGCTGGCTTATCTG
TGAGTTATTCCCGGCGGAGATTCTGCAGATTTTTGGGATGAATGAGCCAGCATCTATGGCATTTGGTATCAAGTGTATGC
GCATTTTTCCGTCCGGACTGGCGTTTACTGGATTTCAGGTGGTGTCAGCCCAGTATTATCTGGCAGCCGGACAGGCAGTG
AAAGCGATGCTGCTTTCCATCCTCCGGCCACTTCTGCTGATGGTACCGCTCATCCATATTTTCTCGGGTATCTGGGGAAT
GGACGGGATTCTGTACGCAGGTCCCACCGCAGACATCCTTACGGCTCTGATTGCAGCAGGTTTGGTTGGATATGACAGCA
GGAAAAAGAGAAAAGGAGTGTGA

Upstream 100 bases:

>100_bases
GCCTTCGGATGAAAAAACCGCAAAAAGTATCATGAATGATTTGCGCTCCTTTGATACGCTAATCCAGCGTAAATGATGAA
AAACCAAAGGAGAAAAAGAG

Downstream 100 bases:

>100_bases
TCATATGGCAGACATTATGGTGCATGGGCTTACCCAGAATAACTTGAAACACGTCACATTCAGAATCCCGAAGGAAAAAA
TCACAGTATTTACCGGGGTG

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDKTIKTVRGNPLAAEPLGRLLIKFAIPSVLSMLVDALYNIVDQIFIGRGVGYLGIAATTVTFPFVTILLSIATLLGIGG
SVYTSMNLGAGKEAEAEKTLGTVFTLSVAIGILFTVICLTFLKPLALAFGATKGAQGSLSYVLDYAPIILLGAPFSMAAI
ALSSMARACGSPILAMGCFLVGAVINLVLDPIYIFVFNWGVKGAAIATVTSQIMSAVILLVYFLKKGHIRLRKKNICPTL
PICGQIFAFGLPSCMIQVAAAILQIELNKAVVSCEMAGVGSEAALSSLGIVLRISSVVVSICVGIALGMQPIIGFNKGAG
FEHRVKETYKKAVGAATVVSVIGWLICELFPAEILQIFGMNEPASMAFGIKCMRIFPSGLAFTGFQVVSAQYYLAAGQAV
KAMLLSILRPLLLMVPLIHIFSGIWGMDGILYAGPTADILTALIAAGLVGYDSRKKRKGV

Sequences:

>Translated_460_residues
MDKTIKTVRGNPLAAEPLGRLLIKFAIPSVLSMLVDALYNIVDQIFIGRGVGYLGIAATTVTFPFVTILLSIATLLGIGG
SVYTSMNLGAGKEAEAEKTLGTVFTLSVAIGILFTVICLTFLKPLALAFGATKGAQGSLSYVLDYAPIILLGAPFSMAAI
ALSSMARACGSPILAMGCFLVGAVINLVLDPIYIFVFNWGVKGAAIATVTSQIMSAVILLVYFLKKGHIRLRKKNICPTL
PICGQIFAFGLPSCMIQVAAAILQIELNKAVVSCEMAGVGSEAALSSLGIVLRISSVVVSICVGIALGMQPIIGFNKGAG
FEHRVKETYKKAVGAATVVSVIGWLICELFPAEILQIFGMNEPASMAFGIKCMRIFPSGLAFTGFQVVSAQYYLAAGQAV
KAMLLSILRPLLLMVPLIHIFSGIWGMDGILYAGPTADILTALIAAGLVGYDSRKKRKGV
>Mature_460_residues
MDKTIKTVRGNPLAAEPLGRLLIKFAIPSVLSMLVDALYNIVDQIFIGRGVGYLGIAATTVTFPFVTILLSIATLLGIGG
SVYTSMNLGAGKEAEAEKTLGTVFTLSVAIGILFTVICLTFLKPLALAFGATKGAQGSLSYVLDYAPIILLGAPFSMAAI
ALSSMARACGSPILAMGCFLVGAVINLVLDPIYIFVFNWGVKGAAIATVTSQIMSAVILLVYFLKKGHIRLRKKNICPTL
PICGQIFAFGLPSCMIQVAAAILQIELNKAVVSCEMAGVGSEAALSSLGIVLRISSVVVSICVGIALGMQPIIGFNKGAG
FEHRVKETYKKAVGAATVVSVIGWLICELFPAEILQIFGMNEPASMAFGIKCMRIFPSGLAFTGFQVVSAQYYLAAGQAV
KAMLLSILRPLLLMVPLIHIFSGIWGMDGILYAGPTADILTALIAAGLVGYDSRKKRKGV

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48356; Mature: 48356

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure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HHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA