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The map label for this gene is hisG [H]

Identifier: 213692246

GI number: 213692246

Start: 1534654

End: 1535505

Strand: Reverse

Name: hisG [H]

Synonym: Blon_1366

Alternate gene names: 213692246

Gene position: 1535505-1534654 (Counterclockwise)

Preceding gene: 213692247

Following gene: 213692245

Centisome position: 54.21

GC content: 62.56

Gene sequence:

>852_bases
ATGCTGAGAATCGCAGTGCCCAACAAGGGCATGCTATCCGAGCCCGCGTGGAACATGCTGGCCGAGGCCGGCTACCGTCT
GCGCATCAACCCTCGCCAGCTGGTCGTGCAAGATCCCGACAATGGCATCGAGTTGTTCTACCTGCGTCCGCTCGATATCG
CCGTATACGTGGGCCGCGGCGCCATCGACGTCGGCATCACCGGCCAGGATCTACTCAAGAACTCCGGTACCGCCGCGCTC
GAGCACATGCCGCTCGGCTTTGGTGCCTCGACCTTCCGTTTCGCCGCACCGAACGAATCCCCGATCACCACCCTGGAGGA
TGTTCAGGGCAAGCGCGTGGCCACCACATTCGATAAGCTCGTACACGACTATCTGGTCGAGCACGGCATCCAGGCCGAGA
CCATCCATCTGGACGGTGCGGTCGAATCCTCCGTGCAGCTGGGCGTGGCCGACCTCATCGCCGACGTGGTCTCCACCGGT
ACCACCCTGCGCAACGCCGGCCTGCGCGTGTTTGCCGAACCGCTCATGCACTCCGAAGCTTGCCTGATTCGTTCGCCGCG
TCTGAACGAGCAGGACCCACGTCTGGCCGTGCTGACCCGCCGTTTGCAAGGCGTGCTCACTGCGCATCAGTATGTGCTGA
TGGACTATGACATTCCGATCAGCAAGGTCGCCGCCGCCGTGGCCGTGACCCCTGGCTTTGAAAGCCCGACGATCTCCCCG
CTGCACGACAAACAGTGGAACGCCGTGCGAGTCATGGTCCCCAAGGCCAAGGTCAACCAGCTGATGGATGATTTGTACGA
AGTCGGCGCACGCGGCATCATCGTTACCGCTCTGCAAGCCTCCCGCATGTAG

Upstream 100 bases:

>100_bases
CCGAGGAAATGAGCCAGCTGCTCTACCACGTCCAGGTCATGATGATCAAGCACGGCCTGACGCTTGAGGACGTCTACAAG
CACCTGTGAGAGGAACGCAA

Downstream 100 bases:

>100_bases
ACTGTTAGTCGATATGACCAACCAGAAAGTCAACGCCAGATACAGTCCGGAAGCACGTGACATCTATTTCACTGTGCCCA
ATTTGATCAGCGCGCTGCGA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLRIAVPNKGMLSEPAWNMLAEAGYRLRINPRQLVVQDPDNGIELFYLRPLDIAVYVGRGAIDVGITGQDLLKNSGTAAL
EHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKLVHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTG
TTLRNAGLRVFAEPLMHSEACLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISP
LHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM

Sequences:

>Translated_283_residues
MLRIAVPNKGMLSEPAWNMLAEAGYRLRINPRQLVVQDPDNGIELFYLRPLDIAVYVGRGAIDVGITGQDLLKNSGTAAL
EHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKLVHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTG
TTLRNAGLRVFAEPLMHSEACLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISP
LHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM
>Mature_283_residues
MLRIAVPNKGMLSEPAWNMLAEAGYRLRINPRQLVVQDPDNGIELFYLRPLDIAVYVGRGAIDVGITGQDLLKNSGTAAL
EHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKLVHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTG
TTLRNAGLRVFAEPLMHSEACLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISP
LHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=292, Percent_Identity=31.8493150684932, Blast_Score=124, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320896, Length=288, Percent_Identity=30.5555555555556, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 30871; Mature: 30871

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAVPNKGMLSEPAWNMLAEAGYRLRINPRQLVVQDPDNGIELFYLRPLDIAVYVGRG
CEEEECCCCCCCCCHHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEEECEEEEEEECCC
AIDVGITGQDLLKNSGTAALEHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKL
EEEECCCHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHH
VHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTGTTLRNAGLRVFAEPLMHSEA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCC
CLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISP
CEEECCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHEEECCCCCCCCCCC
LHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM
CCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MLRIAVPNKGMLSEPAWNMLAEAGYRLRINPRQLVVQDPDNGIELFYLRPLDIAVYVGRG
CEEEECCCCCCCCCHHHHHHHHCCCEEEECCCEEEEECCCCCEEEEEEECEEEEEEECCC
AIDVGITGQDLLKNSGTAALEHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKL
EEEECCCHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHH
VHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTGTTLRNAGLRVFAEPLMHSEA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCC
CLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISP
CEEECCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHEEECCCCCCCCCCC
LHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM
CCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA