| Definition | Bifidobacterium longum subsp. infantis ATCC 15697, complete genome. |
|---|---|
| Accession | NC_011593 |
| Length | 2,832,748 |
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The map label for this gene is gyrA [H]
Identifier: 213691857
GI number: 213691857
Start: 1146375
End: 1149104
Strand: Reverse
Name: gyrA [H]
Synonym: Blon_0966
Alternate gene names: 213691857
Gene position: 1149104-1146375 (Counterclockwise)
Preceding gene: 213691859
Following gene: 213691856
Centisome position: 40.56
GC content: 63.33
Gene sequence:
>2730_bases ATGGCATCACACCGCAAACCGTCCGCGCAAACCTACGATCCGCGCACGGTCAAGGAGCATATCGTCGAGACGCCGCTGAA CGAGGAGATGAGCAAGTCCTTCCTCGAGTATGCGTATTCGGTGATTTACGCACGCGCACTGCCCGATGCGCGCGATGGCT TGAAGCCGGTGCAGCGCCGCATCGTCTACCAGATGGGCGAGATGAACCTGACTCCCGACCACCCGTATATGAAGTCCGCC CGCGTGGTGGGCGAGGTGATGGGCAAGCTCCACCCGCACGGTGATTCCGCGATCTACGAGGCCATGGTGCGTTTGGCACA GCCGTTCGCGATGCGTCTGCCGCTGGTAGACGGCCACGGCAATTTCGGCTCGCTGGATGACGGCCCCGCGGCCTCCCGTT ACACCGAGGCCAGGCTTGGCCCGGCGGCTCTCGGCATGAACGCGGATATCGATGAGGACACCGTCGACTTCACGCCGAAC TATGACAACAAGCTCAAGGAACCGACCGTGCTGCCGGCCGCCATCCCAAATCTGCTGGTCAACGGCGGCTCGGGCATCGC CGTGGGCATGGCCACGAACCTGGCCACCCACAATCTGGGCGAGGTGGTGAACGCCGCCAAGTTCCTCATGGCGCATTCGG ACGCCACCCTGGAACAACTGATGCGTTACGTGCCCGGCCCCGACTGGCCCACCGGCGGCACGATCATCGGCCGCGACGGC ATCCGTGAGGCCTACGCCACCGGCCGTGGTACGTTCACCACGCGCGCCGCCACGCATATCGAGCATGTCACGGCCCGCAA GCAGGCCATCGTGGTCACCGAGCTGCCGTACATGGTGGGCCCAGAGAAGGTAATCGAACGTATTTCCGACGGTGTGAAGA ACCGCAAGCTGGAGGGGATTTCCGGCGCGTTCGATCTGACCGATCGTCATAACGGCACGCGTATCGTCATCGAAATCAAG ACTGGTTTCGACCCGCATGCGGTTCTGGTGCAGTTGTTCAAGCACACACCGTTGCAAGACAACTTCGCCATGAACAACGT GGCGTTGGTGGAGGGCCGCCCGCACACGATGGGTCTGAAGGAGATGCTTCAGGTGTGGGTGGACCACCGCCGTGTGGTGA TTCGCCGCCGCAGTGAATATCGCAAGAAGAAGGCGCTGGAACGCCTGCACCTGGTCGAGGGCCTGCTGCTGGCCATGCTG GACATCGACGAGGTGATTCAGGTAATCCGCACCTCGGATGATGCGGATGCCGCGAAGAGCCGTTTGATGGTCGTTTTCGA TTTGGACGAGGTCCAGGCTCAGTACATCCTCGACCTGCGTCTGCGCCGACTGACCAAGATGAACCGCATCGAACTTGAGG CCGAACGCGATGACCTGAAGAAGCGCATCGAGGAGCTCACCCGCATTCTGGCCTCCGCCGAAGCGCTCGACCAGGTGGTC ACCGACGAGATGGACGAGGCGGTCGCCAAGTGGGGCTCGCCGCGTCGCACCGTGCTGCTGGACGCCGACCCGGATGGCAC GCTGACGCCGGTCGTGGCGCAGGGCGCCGGGGCTTCGGGTGTGTCCAAGTCCGCACTCGAAGCAGTGAAGGCCGCCACCA CGATTTCCTCCGCCGAAGCCGATGTGGCCGCAGCCGCAGCAGCAGCCAAGAAGACCGGCGAACAGTCCGCGCTGACCGGA GCCTTGAAGATCGAGGACGAGCCGTGCGTGGTGATGATGAGCGCCACCGGTTTGATTGCCCGTACCACGCCAAGCGCGAT GGACGTGTTCAATGCACGGTCCGCATCCGATGAACGTCTGCGAGACGATCAGATCACCACAATCTTCGAGACTTCCACGC GCGCCACGTACGGGCTGGTCACGTCGGCCGGCCGCCTGGTGCTCGCGCATGTGGTTGATTTGCCTGCCTTGCCCGCTGCC GCCACATTGTCGCTGAAGGGCGGAGTTCAGGCCGACGAACTGATCGGCATGACCGAATCCACCGATCCGATTCGCGGTGA GCGTGTGATTACGGCGATTGCCATGGAGCAGCCGACGTCCGGCAAGGCCAGTGCCAAGGATGAGAGCGAGGATGGCGGGG CCGCCGAGGCCAAGCCGTTGCCGTCGCTGGCTATCGGTACCCGTAACGGTGTCATCAAGCGTTGGAATCGTGAGGCACCC ACCACCATGGATTCCTGGCCCGTCATTGATCTGAAAGATGGCGATGAAGTGGTATTCGCCGCCGTGGCCGAGGATGACGA CCGTCTGGTGTTCATCTCCTCCGATTCCTCGCTACTGACCTTTGAGGCGAAGAACGTGCGCCCGCAGGGTCGTACCGCGG GCGGTATGGCCGGCATCAAGCTGGCCGAGGGTGCCCGTGTGGCGGCCTTCAACGTGGTTCCCGCCGGCAAGGTGGCATGG ACCTATGAAGAGGGCGAGAACGGCTTGACTTCCGGATCCGGTGCAGTGGTGCTCACCGTGGCCGGCGATTCCGATGCACT GCCCGGCACCGAAAACGGCGCGGCGAAGGTCACTCCGCTGGAAATGTACCCCACCAAGGGTCGTGCTACCGGCGGCGTGC GTTCCCAGCGCTTCCTCAAGGGCCAGAACACGCTGATTCTTGCCTGGGTGGGCCTCTACCCGTTGCACGCTTCCACATCC GCAGGCTCCCCGGTCGAGCTTCCCAAGCCCGATATGCGCCGAGACGGTTCCGGAGTGGACCTCGCCTCCCCCATCGCCTT CATTGCGTAA
Upstream 100 bases:
>100_bases TTGGCGCATCGAAACCAGCGCACAGTTGTTATCGAGAACCGTTCTCTGCGCACTGTTTCGCGCCCTCCCGCTAATATGGG GGCGTTCGAAAGGGAGTTTC
Downstream 100 bases:
>100_bases CCTCAATTAAGCTCCCTCTGATGGGCCGAGCCGTAAAGCAAACACCCCCAGTGGGGTGTTTGTAGGCGAGGAACGAACGA CAGTGAGCCAAACAATAGAG
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 909; Mature: 908
Protein sequence:
>909_residues MASHRKPSAQTYDPRTVKEHIVETPLNEEMSKSFLEYAYSVIYARALPDARDGLKPVQRRIVYQMGEMNLTPDHPYMKSA RVVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHGNFGSLDDGPAASRYTEARLGPAALGMNADIDEDTVDFTPN YDNKLKEPTVLPAAIPNLLVNGGSGIAVGMATNLATHNLGEVVNAAKFLMAHSDATLEQLMRYVPGPDWPTGGTIIGRDG IREAYATGRGTFTTRAATHIEHVTARKQAIVVTELPYMVGPEKVIERISDGVKNRKLEGISGAFDLTDRHNGTRIVIEIK TGFDPHAVLVQLFKHTPLQDNFAMNNVALVEGRPHTMGLKEMLQVWVDHRRVVIRRRSEYRKKKALERLHLVEGLLLAML DIDEVIQVIRTSDDADAAKSRLMVVFDLDEVQAQYILDLRLRRLTKMNRIELEAERDDLKKRIEELTRILASAEALDQVV TDEMDEAVAKWGSPRRTVLLDADPDGTLTPVVAQGAGASGVSKSALEAVKAATTISSAEADVAAAAAAAKKTGEQSALTG ALKIEDEPCVVMMSATGLIARTTPSAMDVFNARSASDERLRDDQITTIFETSTRATYGLVTSAGRLVLAHVVDLPALPAA ATLSLKGGVQADELIGMTESTDPIRGERVITAIAMEQPTSGKASAKDESEDGGAAEAKPLPSLAIGTRNGVIKRWNREAP TTMDSWPVIDLKDGDEVVFAAVAEDDDRLVFISSDSSLLTFEAKNVRPQGRTAGGMAGIKLAEGARVAAFNVVPAGKVAW TYEEGENGLTSGSGAVVLTVAGDSDALPGTENGAAKVTPLEMYPTKGRATGGVRSQRFLKGQNTLILAWVGLYPLHASTS AGSPVELPKPDMRRDGSGVDLASPIAFIA
Sequences:
>Translated_909_residues MASHRKPSAQTYDPRTVKEHIVETPLNEEMSKSFLEYAYSVIYARALPDARDGLKPVQRRIVYQMGEMNLTPDHPYMKSA RVVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHGNFGSLDDGPAASRYTEARLGPAALGMNADIDEDTVDFTPN YDNKLKEPTVLPAAIPNLLVNGGSGIAVGMATNLATHNLGEVVNAAKFLMAHSDATLEQLMRYVPGPDWPTGGTIIGRDG IREAYATGRGTFTTRAATHIEHVTARKQAIVVTELPYMVGPEKVIERISDGVKNRKLEGISGAFDLTDRHNGTRIVIEIK TGFDPHAVLVQLFKHTPLQDNFAMNNVALVEGRPHTMGLKEMLQVWVDHRRVVIRRRSEYRKKKALERLHLVEGLLLAML DIDEVIQVIRTSDDADAAKSRLMVVFDLDEVQAQYILDLRLRRLTKMNRIELEAERDDLKKRIEELTRILASAEALDQVV TDEMDEAVAKWGSPRRTVLLDADPDGTLTPVVAQGAGASGVSKSALEAVKAATTISSAEADVAAAAAAAKKTGEQSALTG ALKIEDEPCVVMMSATGLIARTTPSAMDVFNARSASDERLRDDQITTIFETSTRATYGLVTSAGRLVLAHVVDLPALPAA ATLSLKGGVQADELIGMTESTDPIRGERVITAIAMEQPTSGKASAKDESEDGGAAEAKPLPSLAIGTRNGVIKRWNREAP TTMDSWPVIDLKDGDEVVFAAVAEDDDRLVFISSDSSLLTFEAKNVRPQGRTAGGMAGIKLAEGARVAAFNVVPAGKVAW TYEEGENGLTSGSGAVVLTVAGDSDALPGTENGAAKVTPLEMYPTKGRATGGVRSQRFLKGQNTLILAWVGLYPLHASTS AGSPVELPKPDMRRDGSGVDLASPIAFIA >Mature_908_residues ASHRKPSAQTYDPRTVKEHIVETPLNEEMSKSFLEYAYSVIYARALPDARDGLKPVQRRIVYQMGEMNLTPDHPYMKSAR VVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHGNFGSLDDGPAASRYTEARLGPAALGMNADIDEDTVDFTPNY DNKLKEPTVLPAAIPNLLVNGGSGIAVGMATNLATHNLGEVVNAAKFLMAHSDATLEQLMRYVPGPDWPTGGTIIGRDGI REAYATGRGTFTTRAATHIEHVTARKQAIVVTELPYMVGPEKVIERISDGVKNRKLEGISGAFDLTDRHNGTRIVIEIKT GFDPHAVLVQLFKHTPLQDNFAMNNVALVEGRPHTMGLKEMLQVWVDHRRVVIRRRSEYRKKKALERLHLVEGLLLAMLD IDEVIQVIRTSDDADAAKSRLMVVFDLDEVQAQYILDLRLRRLTKMNRIELEAERDDLKKRIEELTRILASAEALDQVVT DEMDEAVAKWGSPRRTVLLDADPDGTLTPVVAQGAGASGVSKSALEAVKAATTISSAEADVAAAAAAAKKTGEQSALTGA LKIEDEPCVVMMSATGLIARTTPSAMDVFNARSASDERLRDDQITTIFETSTRATYGLVTSAGRLVLAHVVDLPALPAAA TLSLKGGVQADELIGMTESTDPIRGERVITAIAMEQPTSGKASAKDESEDGGAAEAKPLPSLAIGTRNGVIKRWNREAPT TMDSWPVIDLKDGDEVVFAAVAEDDDRLVFISSDSSLLTFEAKNVRPQGRTAGGMAGIKLAEGARVAAFNVVPAGKVAWT YEEGENGLTSGSGAVVLTVAGDSDALPGTENGAAKVTPLEMYPTKGRATGGVRSQRFLKGQNTLILAWVGLYPLHASTSA GSPVELPKPDMRRDGSGVDLASPIAFIA
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=511, Percent_Identity=24.4618395303327, Blast_Score=78, Evalue=4e-14, Organism=Homo sapiens, GI19913406, Length=173, Percent_Identity=31.2138728323699, Blast_Score=72, Evalue=2e-12, Organism=Escherichia coli, GI1788562, Length=895, Percent_Identity=34.7486033519553, Blast_Score=423, Evalue=1e-119, Organism=Escherichia coli, GI1789396, Length=479, Percent_Identity=43.8413361169102, Blast_Score=377, Evalue=1e-105, Organism=Caenorhabditis elegans, GI212645845, Length=169, Percent_Identity=27.810650887574, Blast_Score=74, Evalue=3e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=240, Percent_Identity=27.9166666666667, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI17136538, Length=290, Percent_Identity=26.551724137931, Blast_Score=70, Evalue=5e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 97778; Mature: 97647
Theoretical pI: Translated: 5.52; Mature: 5.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MASHRKPSAQTYDPRTVKEHIVETPLNEEMSKSFLEYAYSVIYARALPDARDGLKPVQRR CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHH IVYQMGEMNLTPDHPYMKSARVVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHG HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCEEEECCC NFGSLDDGPAASRYTEARLGPAALGMNADIDEDTVDFTPNYDNKLKEPTVLPAAIPNLLV CCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHEE NGGSGIAVGMATNLATHNLGEVVNAAKFLMAHSDATLEQLMRYVPGPDWPTGGTIIGRDG ECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCH IREAYATGRGTFTTRAATHIEHVTARKQAIVVTELPYMVGPEKVIERISDGVKNRKLEGI HHHHHHCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCHHHCCCCCC SGAFDLTDRHNGTRIVIEIKTGFDPHAVLVQLFKHTPLQDNFAMNNVALVEGRPHTMGLK CCEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHH EMLQVWVDHRRVVIRRRSEYRKKKALERLHLVEGLLLAMLDIDEVIQVIRTSDDADAAKS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHC RLMVVFDLDEVQAQYILDLRLRRLTKMNRIELEAERDDLKKRIEELTRILASAEALDQVV CEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH TDEMDEAVAKWGSPRRTVLLDADPDGTLTPVVAQGAGASGVSKSALEAVKAATTISSAEA HHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCHH DVAAAAAAAKKTGEQSALTGALKIEDEPCVVMMSATGLIARTTPSAMDVFNARSASDERL HHHHHHHHHHHCCCHHHEEEEEEECCCCEEEEEECCCEEEECCCHHHHHHHCCCCCHHHH RDDQITTIFETSTRATYGLVTSAGRLVLAHVVDLPALPAAATLSLKGGVQADELIGMTES CCCCEEEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCC TDPIRGERVITAIAMEQPTSGKASAKDESEDGGAAEAKPLPSLAIGTRNGVIKRWNREAP CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCC TTMDSWPVIDLKDGDEVVFAAVAEDDDRLVFISSDSSLLTFEAKNVRPQGRTAGGMAGIK CCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCEE LAEGARVAAFNVVPAGKVAWTYEEGENGLTSGSGAVVLTVAGDSDALPGTENGAAKVTPL ECCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEE EMYPTKGRATGGVRSQRFLKGQNTLILAWVGLYPLHASTSAGSPVELPKPDMRRDGSGVD EECCCCCCCCCCCCHHHHHCCCCEEEEEEECEEEEECCCCCCCCCCCCCCCCCCCCCCCC LASPIAFIA HHCCHHHCC >Mature Secondary Structure ASHRKPSAQTYDPRTVKEHIVETPLNEEMSKSFLEYAYSVIYARALPDARDGLKPVQRR CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHH IVYQMGEMNLTPDHPYMKSARVVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHG HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCEEEECCC NFGSLDDGPAASRYTEARLGPAALGMNADIDEDTVDFTPNYDNKLKEPTVLPAAIPNLLV CCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHEE NGGSGIAVGMATNLATHNLGEVVNAAKFLMAHSDATLEQLMRYVPGPDWPTGGTIIGRDG ECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCCH IREAYATGRGTFTTRAATHIEHVTARKQAIVVTELPYMVGPEKVIERISDGVKNRKLEGI HHHHHHCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCHHHCCCCCC SGAFDLTDRHNGTRIVIEIKTGFDPHAVLVQLFKHTPLQDNFAMNNVALVEGRPHTMGLK CCEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHH EMLQVWVDHRRVVIRRRSEYRKKKALERLHLVEGLLLAMLDIDEVIQVIRTSDDADAAKS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHC RLMVVFDLDEVQAQYILDLRLRRLTKMNRIELEAERDDLKKRIEELTRILASAEALDQVV CEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH TDEMDEAVAKWGSPRRTVLLDADPDGTLTPVVAQGAGASGVSKSALEAVKAATTISSAEA HHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCHH DVAAAAAAAKKTGEQSALTGALKIEDEPCVVMMSATGLIARTTPSAMDVFNARSASDERL HHHHHHHHHHHCCCHHHEEEEEEECCCCEEEEEECCCEEEECCCHHHHHHHCCCCCHHHH RDDQITTIFETSTRATYGLVTSAGRLVLAHVVDLPALPAAATLSLKGGVQADELIGMTES CCCCEEEEEECCCCCEEHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCC TDPIRGERVITAIAMEQPTSGKASAKDESEDGGAAEAKPLPSLAIGTRNGVIKRWNREAP CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCCC TTMDSWPVIDLKDGDEVVFAAVAEDDDRLVFISSDSSLLTFEAKNVRPQGRTAGGMAGIK CCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCEE LAEGARVAAFNVVPAGKVAWTYEEGENGLTSGSGAVVLTVAGDSDALPGTENGAAKVTPL ECCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEE EMYPTKGRATGGVRSQRFLKGQNTLILAWVGLYPLHASTSAGSPVELPKPDMRRDGSGVD EECCCCCCCCCCCCHHHHHCCCCEEEEEEECEEEEECCCCCCCCCCCCCCCCCCCCCCCC LASPIAFIA HHCCHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11466286 [H]