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The map label for this gene is serA [H]

Identifier: 213691739

GI number: 213691739

Start: 995512

End: 996711

Strand: Reverse

Name: serA [H]

Synonym: Blon_0845

Alternate gene names: 213691739

Gene position: 996711-995512 (Counterclockwise)

Preceding gene: 213691740

Following gene: 213691736

Centisome position: 35.19

GC content: 59.33

Gene sequence:

>1200_bases
ATGCCCAAAGCACTGTTATTGGAAAACATTCACCCCGACGCGGCCAAGTCGTTGCGTGACCACGGTTTCGAAGTCGAGAC
CATGAAGGGCGCCTTGAGCGAGGACGAGCTCATCGACGCGCTGGATGGCGTGGACCTGGTGGGCGTGCGGTCCAAGACCA
ACGTCACAGCCCGCGTGCTGGATGCGCGTCCTACGCTCAGCGCCATCGGCTGCTTCTGCATCGGCACCAATCAGGTCGAC
CTGGAGTACGCCGGCAAGCGTGGCATCGCCGTGTTCAACGCTCCCTACTCCAACACCCGTTCCGTGGTGGAATTGGTGAT
TTGCGACATCATCTGCTTGATGCGCCGCATTCCCGCACACACGCATCACATCAAGCATGGCCTGTGGGACAAGTCCGCTT
CCGGCTCGCATGAAGTGCGCGGCAAGACCCTCGGCATCATAGGCTACGGCAACATCGGCTCCCAGCTGTCGGTACTGGCC
GAGGCCCTCGGCATGCGCGTGGTGTTCTACGACATTGAGGAGAAACTGGCACTGGGCAACGCCCACCGTTGCGACACCCT
CAACGAACTGCTGGAGCAGTCCGATGCCGTGACCCTGCACGTGGATGGCCGCAAGTCGAACACCGGCTTCTTCGGCGAAG
ACCAATTCGCCCACATGAAGCAGGACGCGATTTTCATTAACCTTTCGCGCGGTTTCGTCGCCGATCTGGGAGCTCTGAAG
CAGCACCTCGATTCCGGCCATCTGTCTGGCGCGGCGGTCGACGTGTTCCCCGTTGAACCGAAGAAGAGCGGAGATCCGTT
CGAGACCTCACTGGCCAATGAAGACAATATGATTCTGACTCCTCATATTGGCGGCTCCACCTTGGAAGCTCAGGAATCCA
TCGGCCATTTCGTCTCTCAGCGTCTTGAGGATTACTGGTTCAGGGGTTCTACCTCCTTGTCCGTGAACCTACCGCAGATC
AACCTCGGTGAGTGCGAGGGTGTGTGCCGTATCGCCCATCTGCACGACAATCTTCCTGGTGTGCTGGCTCATGTCAATCG
TGTGCTCGGCGAGGAGAACATCAACGTTTCCTTCCAGTCGCTGGCCACCGAAGGCGAACTTGGCTATGTGGTCACCGACG
TGGCTCAGAAGCCCAGCGCCGCCACGCTTGAAGCACTGCGCAGCATCGAGGGCACCATTCGCATGCGTGTCATCAGCTGA

Upstream 100 bases:

>100_bases
GCTTCGGACCTGTACGTGGCAATGACCAGGCCGACCCAGAAACTGGTTATAGTTCGGACAAAAACAGACGAGAAGTCCCT
GAACATCTAAGGTATGAAGC

Downstream 100 bases:

>100_bases
CGCAGCTCATCCTCGATTGATATGAAAGAGACCCGTCGTTGACGGGTCTCTTTCATAAGTGCAGGGCTTCATGATTGGCG
CGCACCATGGTTTGCGAATC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPKALLLENIHPDAAKSLRDHGFEVETMKGALSEDELIDALDGVDLVGVRSKTNVTARVLDARPTLSAIGCFCIGTNQVD
LEYAGKRGIAVFNAPYSNTRSVVELVICDIICLMRRIPAHTHHIKHGLWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLA
EALGMRVVFYDIEEKLALGNAHRCDTLNELLEQSDAVTLHVDGRKSNTGFFGEDQFAHMKQDAIFINLSRGFVADLGALK
QHLDSGHLSGAAVDVFPVEPKKSGDPFETSLANEDNMILTPHIGGSTLEAQESIGHFVSQRLEDYWFRGSTSLSVNLPQI
NLGECEGVCRIAHLHDNLPGVLAHVNRVLGEENINVSFQSLATEGELGYVVTDVAQKPSAATLEALRSIEGTIRMRVIS

Sequences:

>Translated_399_residues
MPKALLLENIHPDAAKSLRDHGFEVETMKGALSEDELIDALDGVDLVGVRSKTNVTARVLDARPTLSAIGCFCIGTNQVD
LEYAGKRGIAVFNAPYSNTRSVVELVICDIICLMRRIPAHTHHIKHGLWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLA
EALGMRVVFYDIEEKLALGNAHRCDTLNELLEQSDAVTLHVDGRKSNTGFFGEDQFAHMKQDAIFINLSRGFVADLGALK
QHLDSGHLSGAAVDVFPVEPKKSGDPFETSLANEDNMILTPHIGGSTLEAQESIGHFVSQRLEDYWFRGSTSLSVNLPQI
NLGECEGVCRIAHLHDNLPGVLAHVNRVLGEENINVSFQSLATEGELGYVVTDVAQKPSAATLEALRSIEGTIRMRVIS
>Mature_398_residues
PKALLLENIHPDAAKSLRDHGFEVETMKGALSEDELIDALDGVDLVGVRSKTNVTARVLDARPTLSAIGCFCIGTNQVDL
EYAGKRGIAVFNAPYSNTRSVVELVICDIICLMRRIPAHTHHIKHGLWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLAE
ALGMRVVFYDIEEKLALGNAHRCDTLNELLEQSDAVTLHVDGRKSNTGFFGEDQFAHMKQDAIFINLSRGFVADLGALKQ
HLDSGHLSGAAVDVFPVEPKKSGDPFETSLANEDNMILTPHIGGSTLEAQESIGHFVSQRLEDYWFRGSTSLSVNLPQIN
LGECEGVCRIAHLHDNLPGVLAHVNRVLGEENINVSFQSLATEGELGYVVTDVAQKPSAATLEALRSIEGTIRMRVIS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=305, Percent_Identity=36.0655737704918, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI145580578, Length=229, Percent_Identity=34.9344978165939, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4557499, Length=229, Percent_Identity=34.9344978165939, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI145580575, Length=229, Percent_Identity=34.9344978165939, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4557497, Length=221, Percent_Identity=34.841628959276, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI61743967, Length=221, Percent_Identity=34.841628959276, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1789279, Length=399, Percent_Identity=48.8721804511278, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=32.6693227091633, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=295, Percent_Identity=26.7796610169492, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=255, Percent_Identity=29.8039215686275, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=32.0261437908497, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=192, Percent_Identity=30.7291666666667, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=409, Percent_Identity=45.2322738386308, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6320925, Length=411, Percent_Identity=45.2554744525547, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=28.3088235294118, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=25.5144032921811, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=189, Percent_Identity=26.984126984127, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=31.023102310231, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646448, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646452, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646450, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574286, Length=277, Percent_Identity=27.7978339350181, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=301, Percent_Identity=26.2458471760797, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=301, Percent_Identity=26.2458471760797, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=301, Percent_Identity=26.2458471760797, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=301, Percent_Identity=26.2458471760797, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574284, Length=301, Percent_Identity=26.2458471760797, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=26.1648745519713, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585516, Length=294, Percent_Identity=23.8095238095238, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43281; Mature: 43149

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKALLLENIHPDAAKSLRDHGFEVETMKGALSEDELIDALDGVDLVGVRSKTNVTARVL
CCCCCEECCCCCHHHHHHHHCCCEEEHHHCCCCHHHHHHHHCCCEEEEECCCCCCEEEEE
DARPTLSAIGCFCIGTNQVDLEYAGKRGIAVFNAPYSNTRSVVELVICDIICLMRRIPAH
ECCCCHHHHEEEEECCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCH
THHIKHGLWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLAEALGMRVVFYDIEEKLALGN
HHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECHHHHHCCC
AHRCDTLNELLEQSDAVTLHVDGRKSNTGFFGEDQFAHMKQDAIFINLSRGFVADLGALK
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHH
QHLDSGHLSGAAVDVFPVEPKKSGDPFETSLANEDNMILTPHIGGSTLEAQESIGHFVSQ
HHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
RLEDYWFRGSTSLSVNLPQINLGECEGVCRIAHLHDNLPGVLAHVNRVLGEENINVSFQS
HHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCEEHHH
LATEGELGYVVTDVAQKPSAATLEALRSIEGTIRMRVIS
HCCCCCCCEEEEHHHCCCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
PKALLLENIHPDAAKSLRDHGFEVETMKGALSEDELIDALDGVDLVGVRSKTNVTARVL
CCCCEECCCCCHHHHHHHHCCCEEEHHHCCCCHHHHHHHHCCCEEEEECCCCCCEEEEE
DARPTLSAIGCFCIGTNQVDLEYAGKRGIAVFNAPYSNTRSVVELVICDIICLMRRIPAH
ECCCCHHHHEEEEECCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCH
THHIKHGLWDKSASGSHEVRGKTLGIIGYGNIGSQLSVLAEALGMRVVFYDIEEKLALGN
HHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECHHHHHCCC
AHRCDTLNELLEQSDAVTLHVDGRKSNTGFFGEDQFAHMKQDAIFINLSRGFVADLGALK
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHH
QHLDSGHLSGAAVDVFPVEPKKSGDPFETSLANEDNMILTPHIGGSTLEAQESIGHFVSQ
HHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
RLEDYWFRGSTSLSVNLPQINLGECEGVCRIAHLHDNLPGVLAHVNRVLGEENINVSFQS
HHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCEEHHH
LATEGELGYVVTDVAQKPSAATLEALRSIEGTIRMRVIS
HCCCCCCCEEEEHHHCCCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]