Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 213691678

GI number: 213691678

Start: 907798

End: 908586

Strand: Direct

Name: uppS [H]

Synonym: Blon_0783

Alternate gene names: 213691678

Gene position: 907798-908586 (Clockwise)

Preceding gene: 213691677

Following gene: 213691687

Centisome position: 32.05

GC content: 60.46

Gene sequence:

>789_bases
ATGGCTTTTGAGAACGTTGATTACACCTCGCTGAACATCCCCGCGGCCCCATTCAGCGACCCCGCCCGTATTCCCGACTT
CCCCAAGAACAAAGTGCCTCGCCATATCGGCGTGATTATGGACGGCAACGGCCGTTGGGCCAAGCAGCGTGGCATGATCC
GCACCAATGGGCATCAGGCCGCCGAACCGGTGGTGTTCGACACGATCGCCGGCGCCATCGAGGCCGGGGTGCGCTATTTG
AGCCTGTATACGTTCTCCACTGAAAACTGGAAGCGTTCGCCCCAGGAAGTGCGCTTCCTCATGGGCTTCTCGCGTGAGAT
TATCCACCGCCGCGTGGAACAGATGGACGAGTGGGGTGTGCGCGTGCGCTGGTCCGGCCGTCGCCCCAAGCTGTGGAAGT
CGGTGATCGACGAGCTTGAGGCCGCCGAGGAGCGTACCAAGAACAACAAGGTCATCGATGTGGTGTTCTGCATCAACTAT
GGTGGCCGTGCTGAAATCGCCGACGCCTGTGCCGCCATCGCTCGCGAAGTGCGTGACGGCAAGATTTCCGGCGACCGTGT
GACCGAGAAGATGATTGCCGACCATCTGTACAATCCGGACATTCCTGATTGCGACTTGGTGATTCGTACTTCCGGCGAAC
AGCGCACCTCCAACTTCCTGCCGTGGGAGGCCGCCTACGCCGAGCTCGACTTCGTGCCCGAACTCTTCCCGGACTGCGGC
CGTGACGTGCTATGGCGCTCCATCGACCATTACATCCACCGCGATCGCCGATTTGGCGGCGTGAAATAA

Upstream 100 bases:

>100_bases
CCGCACCGGTGGAGCGGGTCGTACGGGAGTTGGTTGAAGATTGGGGGGAGTATTACCTTGAACGGCCGATTCGTTCGCTG
CGCTTGATAGATTCGTAGGT

Downstream 100 bases:

>100_bases
AGAACAGTCCGGTGGACTGTTCGTTCACGCCGCCTGGCCGAGGCCGATAGGACATGACCAGGTAATGATGAGTCCGGCGA
AGCCGGTCCTTGATTGCTGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAFENVDYTSLNIPAAPFSDPARIPDFPKNKVPRHIGVIMDGNGRWAKQRGMIRTNGHQAAEPVVFDTIAGAIEAGVRYL
SLYTFSTENWKRSPQEVRFLMGFSREIIHRRVEQMDEWGVRVRWSGRRPKLWKSVIDELEAAEERTKNNKVIDVVFCINY
GGRAEIADACAAIAREVRDGKISGDRVTEKMIADHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCG
RDVLWRSIDHYIHRDRRFGGVK

Sequences:

>Translated_262_residues
MAFENVDYTSLNIPAAPFSDPARIPDFPKNKVPRHIGVIMDGNGRWAKQRGMIRTNGHQAAEPVVFDTIAGAIEAGVRYL
SLYTFSTENWKRSPQEVRFLMGFSREIIHRRVEQMDEWGVRVRWSGRRPKLWKSVIDELEAAEERTKNNKVIDVVFCINY
GGRAEIADACAAIAREVRDGKISGDRVTEKMIADHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCG
RDVLWRSIDHYIHRDRRFGGVK
>Mature_261_residues
AFENVDYTSLNIPAAPFSDPARIPDFPKNKVPRHIGVIMDGNGRWAKQRGMIRTNGHQAAEPVVFDTIAGAIEAGVRYLS
LYTFSTENWKRSPQEVRFLMGFSREIIHRRVEQMDEWGVRVRWSGRRPKLWKSVIDELEAAEERTKNNKVIDVVFCINYG
GRAEIADACAAIAREVRDGKISGDRVTEKMIADHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCGR
DVLWRSIDHYIHRDRRFGGVK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=210, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI45580738, Length=210, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=37.117903930131, Blast_Score=164, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=33.4801762114537, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=37.037037037037, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=31.5789473684211, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30039; Mature: 29908

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFENVDYTSLNIPAAPFSDPARIPDFPKNKVPRHIGVIMDGNGRWAKQRGMIRTNGHQA
CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCEEECCCCC
AEPVVFDTIAGAIEAGVRYLSLYTFSTENWKRSPQEVRFLMGFSREIIHRRVEQMDEWGV
CCCHHHHHHHHHHHHHHHEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
RVRWSGRRPKLWKSVIDELEAAEERTKNNKVIDVVFCINYGGRAEIADACAAIAREVRDG
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
KISGDRVTEKMIADHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCG
CCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
RDVLWRSIDHYIHRDRRFGGVK
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AFENVDYTSLNIPAAPFSDPARIPDFPKNKVPRHIGVIMDGNGRWAKQRGMIRTNGHQA
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCEEECCCCC
AEPVVFDTIAGAIEAGVRYLSLYTFSTENWKRSPQEVRFLMGFSREIIHRRVEQMDEWGV
CCCHHHHHHHHHHHHHHHEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
RVRWSGRRPKLWKSVIDELEAAEERTKNNKVIDVVFCINYGGRAEIADACAAIAREVRDG
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
KISGDRVTEKMIADHLYNPDIPDCDLVIRTSGEQRTSNFLPWEAAYAELDFVPELFPDCG
CCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
RDVLWRSIDHYIHRDRRFGGVK
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]