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The map label for this gene is cytR [H]

Identifier: 213691563

GI number: 213691563

Start: 767313

End: 768326

Strand: Reverse

Name: cytR [H]

Synonym: Blon_0665

Alternate gene names: 213691563

Gene position: 768326-767313 (Counterclockwise)

Preceding gene: 213691564

Following gene: 213691560

Centisome position: 27.12

GC content: 53.25

Gene sequence:

>1014_bases
GTGGATGATAAGTTTCCGGCACATCATCGCGTTAGCCTGAGCGATGTGTCCAAAGCCGCTCGGATATCCGTTGCCACGGT
GTCTCGAGCCTTTTCTCATCCTGAGCGCGTCAACGCCGATACATTGAGGACCATATACCGTGTGGCGGAGGAAATCGGCT
ATGTGCCGCGCAAAGGTTCTGCATACGCGCATGACGAGTCCAGCAAATTGATCGCCGTGGTGATCAACGACGTTGGAAAC
CCGGTATACGCGGAATTCGTGAAGAGCATCCAGCAGCAGTGTCGGAAGTACGGATATTCGATAATGATCATCGACTCGCA
AGAGATGAGCTCGATCGAACGTATTATGTTGGGTCTGATGGAGGCGTACGTTGCCGGCGTCATACTCGTCTCGTCGCGAT
TGTCCGACGCGAATATCAAGAAGATGGCGAAGATAAAATCCTTGGTGCTTATCAACCGGGCGGTACAAGGCATCAAATCG
GTGATTGCGGATACTCGTACGGGTCTGGAACAGGCCGTCCATGAGTTGCGCTCCCTGGGGCATGAGTCCCTAACCTATTT
ATCAGGGCCAACGGATTCATGGCAGAATATGGTCAGGAAGGAGACGCTGGTCAGCATATGCCGACAGAATGATATCGCTT
TGAACTGCATACCATGTTCCGCTCCCACCTACAGCGGAGGATTCGCCTGTCTCCCACAATTCTCGCAACATGCCACATCT
GCGGTGATCGCCTATAACGACATCATGGCCGTCGGCTTCATGGCCGCGCTGGAGGAATACGGAATGGAAGTCCCCGAAAA
GGTGTCTGTTGTGGGAATCGACGACATTCCCATCAGCGGAATCGTCAATCCGACATTGTCGACGATTCATATCGATCGTG
CGACGATAGGGAAAATGGCGGTGGATGAATTGGTCAGTCGACTGCGCGGAGGAAACCTCCATCGATTGCTGAAACCGATT
ATGTTGGACTCTCGTTTCATCGCACGTGGCAGCACCGGACCCCGGCGAGATTGA

Upstream 100 bases:

>100_bases
TGCGGTTTTCTTTTATGGATAAGGGGCTGCGGACGTTTTCTTGGAGATAATCACGCAGCCCCCTACCGAAGTGAAGGGAT
AAATCATCGGAAGGGAAATT

Downstream 100 bases:

>100_bases
AAGCTATGGGCTAACAATCCGCAAGCGGAATGCCGATACTATCCCGTTCTATGAAGCTGGTAGGTATTTCCCAAAGGCCC
TGTTTGCCCGCGTTCGATTG

Product: periplasmic binding protein/LacI transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MDDKFPAHHRVSLSDVSKAARISVATVSRAFSHPERVNADTLRTIYRVAEEIGYVPRKGSAYAHDESSKLIAVVINDVGN
PVYAEFVKSIQQQCRKYGYSIMIIDSQEMSSIERIMLGLMEAYVAGVILVSSRLSDANIKKMAKIKSLVLINRAVQGIKS
VIADTRTGLEQAVHELRSLGHESLTYLSGPTDSWQNMVRKETLVSICRQNDIALNCIPCSAPTYSGGFACLPQFSQHATS
AVIAYNDIMAVGFMAALEEYGMEVPEKVSVVGIDDIPISGIVNPTLSTIHIDRATIGKMAVDELVSRLRGGNLHRLLKPI
MLDSRFIARGSTGPRRD

Sequences:

>Translated_337_residues
MDDKFPAHHRVSLSDVSKAARISVATVSRAFSHPERVNADTLRTIYRVAEEIGYVPRKGSAYAHDESSKLIAVVINDVGN
PVYAEFVKSIQQQCRKYGYSIMIIDSQEMSSIERIMLGLMEAYVAGVILVSSRLSDANIKKMAKIKSLVLINRAVQGIKS
VIADTRTGLEQAVHELRSLGHESLTYLSGPTDSWQNMVRKETLVSICRQNDIALNCIPCSAPTYSGGFACLPQFSQHATS
AVIAYNDIMAVGFMAALEEYGMEVPEKVSVVGIDDIPISGIVNPTLSTIHIDRATIGKMAVDELVSRLRGGNLHRLLKPI
MLDSRFIARGSTGPRRD
>Mature_337_residues
MDDKFPAHHRVSLSDVSKAARISVATVSRAFSHPERVNADTLRTIYRVAEEIGYVPRKGSAYAHDESSKLIAVVINDVGN
PVYAEFVKSIQQQCRKYGYSIMIIDSQEMSSIERIMLGLMEAYVAGVILVSSRLSDANIKKMAKIKSLVLINRAVQGIKS
VIADTRTGLEQAVHELRSLGHESLTYLSGPTDSWQNMVRKETLVSICRQNDIALNCIPCSAPTYSGGFACLPQFSQHATS
AVIAYNDIMAVGFMAALEEYGMEVPEKVSVVGIDDIPISGIVNPTLSTIHIDRATIGKMAVDELVSRLRGGNLHRLLKPI
MLDSRFIARGSTGPRRD

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=27.710843373494, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788474, Length=314, Percent_Identity=30.8917197452229, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1790194, Length=327, Percent_Identity=26.2996941896024, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789202, Length=286, Percent_Identity=25.8741258741259, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789068, Length=331, Percent_Identity=27.7945619335347, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787948, Length=341, Percent_Identity=23.4604105571848, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994940, Length=325, Percent_Identity=22.1538461538462, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786540, Length=314, Percent_Identity=25.4777070063694, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790715, Length=320, Percent_Identity=24.375, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787906, Length=309, Percent_Identity=22.6537216828479, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790689, Length=307, Percent_Identity=20.8469055374593, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789456, Length=345, Percent_Identity=21.7391304347826, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36952; Mature: 36952

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKFPAHHRVSLSDVSKAARISVATVSRAFSHPERVNADTLRTIYRVAEEIGYVPRKGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
AYAHDESSKLIAVVINDVGNPVYAEFVKSIQQQCRKYGYSIMIIDSQEMSSIERIMLGLM
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHH
EAYVAGVILVSSRLSDANIKKMAKIKSLVLINRAVQGIKSVIADTRTGLEQAVHELRSLG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HESLTYLSGPTDSWQNMVRKETLVSICRQNDIALNCIPCSAPTYSGGFACLPQFSQHATS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHH
AVIAYNDIMAVGFMAALEEYGMEVPEKVSVVGIDDIPISGIVNPTLSTIHIDRATIGKMA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHEEEECHHHHHHHH
VDELVSRLRGGNLHRLLKPIMLDSRFIARGSTGPRRD
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCC
>Mature Secondary Structure
MDDKFPAHHRVSLSDVSKAARISVATVSRAFSHPERVNADTLRTIYRVAEEIGYVPRKGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
AYAHDESSKLIAVVINDVGNPVYAEFVKSIQQQCRKYGYSIMIIDSQEMSSIERIMLGLM
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHH
EAYVAGVILVSSRLSDANIKKMAKIKSLVLINRAVQGIKSVIADTRTGLEQAVHELRSLG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HESLTYLSGPTDSWQNMVRKETLVSICRQNDIALNCIPCSAPTYSGGFACLPQFSQHATS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHH
AVIAYNDIMAVGFMAALEEYGMEVPEKVSVVGIDDIPISGIVNPTLSTIHIDRATIGKMA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHEEEECHHHHHHHH
VDELVSRLRGGNLHRLLKPIMLDSRFIARGSTGPRRD
HHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]