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The map label for this gene is sulD [H]

Identifier: 213691457

GI number: 213691457

Start: 623564

End: 624976

Strand: Direct

Name: sulD [H]

Synonym: Blon_0552

Alternate gene names: 213691457

Gene position: 623564-624976 (Clockwise)

Preceding gene: 213691456

Following gene: 213691458

Centisome position: 22.01

GC content: 59.59

Gene sequence:

>1413_bases
ATGGACACCATCACACTTACCGGCGTACATGCCAACGGCACCCACGGTGTGCTCGCCTTCGAACACGAACGGCCACAAAC
CTTCGTCGTGGATGTCACCCTGCACCTTGATCTGGCCGCAGCCGGTCAATCCGACGATCTCAACGACACCATCGATTACG
GCCGTGTGGCCAAGGACATCACGGCTGTCATCGAAGGCCCTCATGTGGACCTGATCGAGCGTCTGGCCCAACGTATCGCG
GACGAGATTCTTGCCGATGCGCCGGCCGTCGCCTCCATCGACGTCACCGTGCACAAGCCTCACGCACCCATCGTCGTGGC
TTTTGCAGATGTATCGGTCTCCATCTCGCGCGTGCGTGCCACCGATAATGGACGTACTGCTGAAGAGCATGCCATCCATA
ACGCGGTGGTGGCCTTGGGCGGCAATGTGGGCGAGGTGGAATCCACCTTGCGAGCCGCCGTTCGGGAGATTGACGCGTTG
CCTGGCACACAGGTGACTGGTATCTCACCGCTTTACCGCACGGCCGCGTGGGGCATGGCCGACGGTACGCCGGATTTCCT
GAACGCCGTGGTGGAGCTTGAAACCACAATGGGCAGCCACGAATTGCTTGCCGCGTTGCAAAACATCGAAGCGAACCATG
GACGAATTCGTGAGAATCATTGGGATTCCAGGCCGTTGGACTTGGACATTATCGACTTTGATGGCATCACCAGCGCGGAT
CCGGATCTGGCATTGCCCCATCCGCGTGCTTGGCAGCGTGCGTTTGTGCTGGCTCCTTGGTTGGCATTGAATCCGAACGC
CAAACTCGCCGGAGCCCATGAGGGGCCTGTAGCCGATTTGCTGGCCACCGCGCCGGACCGTAACGCCGTGCAGCTCGAGA
GCGAAGACTGGATGCTCGGCGGGCATGCAGTCAAGCAAGAATCCGCGTCGGAGTCGGCACCCGTCTCACGCAAGGCGATT
ATTTCGCTGGATTCCACCTCGCAGGATGCCGAACGGCTGTTCCGTGAAACCATCGTTTCCATCGACAGTGTTCCTGGCAA
TCAGGTACAGGGCATTTCGCCGCTCTACCATGTCAGCCATTTCGACGGCCCGGACGCGATGAGCGCGGTCATCCAAATCG
AAACCAAGTTGCCGCCCGCCGACCTGATTGCCGTATTGGGCAGCATCGAAAGCGTTCATGATCTGGCAGTCGACCTTGAC
CTTGTTGACATGGAGGGCGTGACTTCCGACGAGCCCAACTGCAGCATTCCTTGGCCGTCGGCCCGTAACCATGCGTCGGT
ATTGGCACCTTGGCTGGATATGGACCCGAATGCTACTCTGGGCGGCGACCCGGTGGCCTTCCTTTTGGCCATGGCACCGG
ATGCCGGACAGGTCGGATTGCTATCGGACAACTGGATACTGTCGAACAGTTGA

Upstream 100 bases:

>100_bases
GCTCCCTGTTTTGGTTGCTTCTAGGCCTTGGCTCCCCTCGGGCGAGGGGAGCTGGCGCCGAAGGCGACTGAGGGGAGCAT
TTGAGCAGAAAGCCTTACCA

Downstream 100 bases:

>100_bases
ACTGATGGCAGAACCAGTTACGAACGGTAGGCTAGAAACCAGACGGTGACGGACCGGTATCTGACCTCGAACAGCCGGGC
ACGGCAGTGACGAAAACCAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MDTITLTGVHANGTHGVLAFEHERPQTFVVDVTLHLDLAAAGQSDDLNDTIDYGRVAKDITAVIEGPHVDLIERLAQRIA
DEILADAPAVASIDVTVHKPHAPIVVAFADVSVSISRVRATDNGRTAEEHAIHNAVVALGGNVGEVESTLRAAVREIDAL
PGTQVTGISPLYRTAAWGMADGTPDFLNAVVELETTMGSHELLAALQNIEANHGRIRENHWDSRPLDLDIIDFDGITSAD
PDLALPHPRAWQRAFVLAPWLALNPNAKLAGAHEGPVADLLATAPDRNAVQLESEDWMLGGHAVKQESASESAPVSRKAI
ISLDSTSQDAERLFRETIVSIDSVPGNQVQGISPLYHVSHFDGPDAMSAVIQIETKLPPADLIAVLGSIESVHDLAVDLD
LVDMEGVTSDEPNCSIPWPSARNHASVLAPWLDMDPNATLGGDPVAFLLAMAPDAGQVGLLSDNWILSNS

Sequences:

>Translated_470_residues
MDTITLTGVHANGTHGVLAFEHERPQTFVVDVTLHLDLAAAGQSDDLNDTIDYGRVAKDITAVIEGPHVDLIERLAQRIA
DEILADAPAVASIDVTVHKPHAPIVVAFADVSVSISRVRATDNGRTAEEHAIHNAVVALGGNVGEVESTLRAAVREIDAL
PGTQVTGISPLYRTAAWGMADGTPDFLNAVVELETTMGSHELLAALQNIEANHGRIRENHWDSRPLDLDIIDFDGITSAD
PDLALPHPRAWQRAFVLAPWLALNPNAKLAGAHEGPVADLLATAPDRNAVQLESEDWMLGGHAVKQESASESAPVSRKAI
ISLDSTSQDAERLFRETIVSIDSVPGNQVQGISPLYHVSHFDGPDAMSAVIQIETKLPPADLIAVLGSIESVHDLAVDLD
LVDMEGVTSDEPNCSIPWPSARNHASVLAPWLDMDPNATLGGDPVAFLLAMAPDAGQVGLLSDNWILSNS
>Mature_470_residues
MDTITLTGVHANGTHGVLAFEHERPQTFVVDVTLHLDLAAAGQSDDLNDTIDYGRVAKDITAVIEGPHVDLIERLAQRIA
DEILADAPAVASIDVTVHKPHAPIVVAFADVSVSISRVRATDNGRTAEEHAIHNAVVALGGNVGEVESTLRAAVREIDAL
PGTQVTGISPLYRTAAWGMADGTPDFLNAVVELETTMGSHELLAALQNIEANHGRIRENHWDSRPLDLDIIDFDGITSAD
PDLALPHPRAWQRAFVLAPWLALNPNAKLAGAHEGPVADLLATAPDRNAVQLESEDWMLGGHAVKQESASESAPVSRKAI
ISLDSTSQDAERLFRETIVSIDSVPGNQVQGISPLYHVSHFDGPDAMSAVIQIETKLPPADLIAVLGSIESVHDLAVDLD
LVDMEGVTSDEPNCSIPWPSARNHASVLAPWLDMDPNATLGGDPVAFLLAMAPDAGQVGLLSDNWILSNS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=132, Percent_Identity=35.6060606060606, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324073, Length=242, Percent_Identity=26.8595041322314, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 50011; Mature: 50011

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTITLTGVHANGTHGVLAFEHERPQTFVVDVTLHLDLAAAGQSDDLNDTIDYGRVAKDI
CCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
TAVIEGPHVDLIERLAQRIADEILADAPAVASIDVTVHKPHAPIVVAFADVSVSISRVRA
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCEEEEEEEEE
TDNGRTAEEHAIHNAVVALGGNVGEVESTLRAAVREIDALPGTQVTGISPLYRTAAWGMA
CCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC
DGTPDFLNAVVELETTMGSHELLAALQNIEANHGRIRENHWDSRPLDLDIIDFDGITSAD
CCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
PDLALPHPRAWQRAFVLAPWLALNPNAKLAGAHEGPVADLLATAPDRNAVQLESEDWMLG
CCCCCCCCHHHHHHEEEECEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEC
GHAVKQESASESAPVSRKAIISLDSTSQDAERLFRETIVSIDSVPGNQVQGISPLYHVSH
CHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEECC
FDGPDAMSAVIQIETKLPPADLIAVLGSIESVHDLAVDLDLVDMEGVTSDEPNCSIPWPS
CCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCC
ARNHASVLAPWLDMDPNATLGGDPVAFLLAMAPDAGQVGLLSDNWILSNS
CCCCCCEEECCCCCCCCCCCCCCHHEEEEEECCCCCCEEEEECCEEEECC
>Mature Secondary Structure
MDTITLTGVHANGTHGVLAFEHERPQTFVVDVTLHLDLAAAGQSDDLNDTIDYGRVAKDI
CCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHH
TAVIEGPHVDLIERLAQRIADEILADAPAVASIDVTVHKPHAPIVVAFADVSVSISRVRA
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCEEEEEEEEE
TDNGRTAEEHAIHNAVVALGGNVGEVESTLRAAVREIDALPGTQVTGISPLYRTAAWGMA
CCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC
DGTPDFLNAVVELETTMGSHELLAALQNIEANHGRIRENHWDSRPLDLDIIDFDGITSAD
CCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
PDLALPHPRAWQRAFVLAPWLALNPNAKLAGAHEGPVADLLATAPDRNAVQLESEDWMLG
CCCCCCCCHHHHHHEEEECEEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEC
GHAVKQESASESAPVSRKAIISLDSTSQDAERLFRETIVSIDSVPGNQVQGISPLYHVSH
CHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEECC
FDGPDAMSAVIQIETKLPPADLIAVLGSIESVHDLAVDLDLVDMEGVTSDEPNCSIPWPS
CCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCC
ARNHASVLAPWLDMDPNATLGGDPVAFLLAMAPDAGQVGLLSDNWILSNS
CCCCCCEEECCCCCCCCCCCCCCHHEEEEEECCCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]