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The map label for this gene is folP1 [H]

Identifier: 213691456

GI number: 213691456

Start: 622580

End: 623455

Strand: Direct

Name: folP1 [H]

Synonym: Blon_0551

Alternate gene names: 213691456

Gene position: 622580-623455 (Clockwise)

Preceding gene: 213691455

Following gene: 213691457

Centisome position: 21.98

GC content: 66.32

Gene sequence:

>876_bases
ATGACTGATTTGCAGGCGTTGCATGACAGTACGCGCACCATGGTGATGGGCGTGCTCAACATCACCGAGGACTCGTCCTC
GGACGGCGGCCTGTGGCTGGACCCGGCCAAGGCGGCCCAACACGGGCGCGACATGATGGCCGCCGGCGCGGCCATCATCG
ACATCGGCGCCGAATCCACGCGCCCCGGCGCCAAGCGCGTGTCCGAGGCCGACGAACTGGCCCGCATCACCGGTGCCGTC
AAGACATTGATTCCGGCCGGTGCCATACTGTCCATCGACACCACGCGCGCATCCGTGGCCGCCGCTGCGCTGAGCGAGGG
CGCCCAGATCATCAACGACGTCTCCGGTGGCACGCTGGATGCCGAACTGCCGCATGTGGTCGCCGACCACGACTGCCTGT
ACATCGTGCAGCATTGGCGCGGTTGGCTCGCCGGCTCCAAGGGCGCGAACCCCGATCAAGACACCTCCGTCTACGAGCGC
GGTGTATTGACCGACGTACACGACGAACTCATGCGCCAAGTCGACGGTGTGCTGGCCGCCGGCGTAAAGCCTGAGCGCAT
TATCATCGACCCGGGCCTGGGCTTCTCCAAGCCTGGCATCGAGCACAACCTGCCGCTGCTGACCGGACTCGAGTCCTTCC
GCGCCACTGGATATCCGGTGCTGATCGGCCAGTCCCGCAAACGCTTCATCTCGGCGATGCTTACCGAGGCGGGCGCTGCC
GGTGCTGATGGGCCGATCATGTCCCAGCGCGATGACGTGACCGCAGCCTTGTCCGCCCTGTCCGCCGAACATGGCGCATG
GGCCGTGCGCGTACACGACGTGGCCAAAAGCCGCGCCGCCGTCATCGCCGGCAACACCTGGCGCGAATACGCATGA

Upstream 100 bases:

>100_bases
CACCCGAGCCGAAGCCATGAGCTTGATTCTTGACAAGTGACGCAACCTAGGCTCCCCTCTCTGAGGGGAGCGAAGGGAAA
CAACGAAGGGGAAATAACCT

Downstream 100 bases:

>100_bases
TCCCCCTGGCTCCCTGTTTTGGTTGCTTCTAGGCCTTGGCTCCCCTCGGGCGAGGGGAGCTGGCGCCGAAGGCGACTGAG
GGGAGCATTTGAGCAGAAAG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTDLQALHDSTRTMVMGVLNITEDSSSDGGLWLDPAKAAQHGRDMMAAGAAIIDIGAESTRPGAKRVSEADELARITGAV
KTLIPAGAILSIDTTRASVAAAALSEGAQIINDVSGGTLDAELPHVVADHDCLYIVQHWRGWLAGSKGANPDQDTSVYER
GVLTDVHDELMRQVDGVLAAGVKPERIIIDPGLGFSKPGIEHNLPLLTGLESFRATGYPVLIGQSRKRFISAMLTEAGAA
GADGPIMSQRDDVTAALSALSAEHGAWAVRVHDVAKSRAAVIAGNTWREYA

Sequences:

>Translated_291_residues
MTDLQALHDSTRTMVMGVLNITEDSSSDGGLWLDPAKAAQHGRDMMAAGAAIIDIGAESTRPGAKRVSEADELARITGAV
KTLIPAGAILSIDTTRASVAAAALSEGAQIINDVSGGTLDAELPHVVADHDCLYIVQHWRGWLAGSKGANPDQDTSVYER
GVLTDVHDELMRQVDGVLAAGVKPERIIIDPGLGFSKPGIEHNLPLLTGLESFRATGYPVLIGQSRKRFISAMLTEAGAA
GADGPIMSQRDDVTAALSALSAEHGAWAVRVHDVAKSRAAVIAGNTWREYA
>Mature_290_residues
TDLQALHDSTRTMVMGVLNITEDSSSDGGLWLDPAKAAQHGRDMMAAGAAIIDIGAESTRPGAKRVSEADELARITGAVK
TLIPAGAILSIDTTRASVAAAALSEGAQIINDVSGGTLDAELPHVVADHDCLYIVQHWRGWLAGSKGANPDQDTSVYERG
VLTDVHDELMRQVDGVLAAGVKPERIIIDPGLGFSKPGIEHNLPLLTGLESFRATGYPVLIGQSRKRFISAMLTEAGAAG
ADGPIMSQRDDVTAALSALSAEHGAWAVRVHDVAKSRAAVIAGNTWREYA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=280, Percent_Identity=34.2857142857143, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=30.8641975308642, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30533; Mature: 30402

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLQALHDSTRTMVMGVLNITEDSSSDGGLWLDPAKAAQHGRDMMAAGAAIIDIGAEST
CCCHHHHHHHHHHHHHHHEEECCCCCCCCCEEECHHHHHHCCHHHHHCCCEEEEECCCCC
RPGAKRVSEADELARITGAVKTLIPAGAILSIDTTRASVAAAALSEGAQIINDVSGGTLD
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEC
AELPHVVADHDCLYIVQHWRGWLAGSKGANPDQDTSVYERGVLTDVHDELMRQVDGVLAA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHC
GVKPERIIIDPGLGFSKPGIEHNLPLLTGLESFRATGYPVLIGQSRKRFISAMLTEAGAA
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCC
GADGPIMSQRDDVTAALSALSAEHGAWAVRVHDVAKSRAAVIAGNTWREYA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHCCEEEEECCCHHCCC
>Mature Secondary Structure 
TDLQALHDSTRTMVMGVLNITEDSSSDGGLWLDPAKAAQHGRDMMAAGAAIIDIGAEST
CCHHHHHHHHHHHHHHHEEECCCCCCCCCEEECHHHHHHCCHHHHHCCCEEEEECCCCC
RPGAKRVSEADELARITGAVKTLIPAGAILSIDTTRASVAAAALSEGAQIINDVSGGTLD
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEC
AELPHVVADHDCLYIVQHWRGWLAGSKGANPDQDTSVYERGVLTDVHDELMRQVDGVLAA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHC
GVKPERIIIDPGLGFSKPGIEHNLPLLTGLESFRATGYPVLIGQSRKRFISAMLTEAGAA
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCC
GADGPIMSQRDDVTAALSALSAEHGAWAVRVHDVAKSRAAVIAGNTWREYA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHCCEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]