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The map label for this gene is gyrA [H]

Identifier: 213690935

GI number: 213690935

Start: 7643

End: 10294

Strand: Direct

Name: gyrA [H]

Synonym: Blon_0007

Alternate gene names: 213690935

Gene position: 7643-10294 (Clockwise)

Preceding gene: 213690934

Following gene: 213690936

Centisome position: 0.27

GC content: 65.01

Gene sequence:

>2652_bases
GTGGCAGATGAAAACAACACCGGCGACGAGCAGTTCACGCCGGACGGCTCGATGGAGCCGTTGAGCCCGCAGGAGGCGGA
CACCACCGACTACGGCCTGATGGAGAGCGGCGAACGCATCCAGCGCAAGGACCTGCAGCAGGAGATGCGCGAGTCCTACC
TGGCGTATGCCCTCTCCGTGATCGTCGAGCGTGCCCTGCCGGACGTGCGCGACGGCATGAAGCCCGTGCATCGCCGTGTG
ATCTACGCGATGTACGACGGCGGCTACCGCCCCGATCGCGGCTACAACAAGTGCTCCCGCGTGGTCGGCGACGTGATGGG
TAAGTACCACCCGCACGGCGATTCCGCCATCTACGACACCTTGGTGCGTATGGCCCAGTCCTGGTCGATGCGCAACATGC
TCGTCGACGGCCAGGGCAACTTCGGCTCCCCCGGCGATGACCCGGCCGCCGCCATGCGTTACACCGAATGCCGCATGGCC
CCGCTGGCCATGGAAATGGTGCGCGACATCGACAAGGACACCGTCGACTTCGTGCCCAACTACGACGGCAAGACCCAGGA
GCCGACCGTGCTGCCGGCCCGCTTCCCGAACCTGCTCGTCAACGGTTCCGCCGGCATCGCCGTCGGCATGGCCACCAACA
TCCCGCCGCATAACATGCGCGAGGTGGCGGACGGCGTCCACTGGGCGCTCGACCATCCGGACGCCAGCCGCGAGGAACTG
CTGGAAAACCTGATCCGCATCATCAAGGGACCGGACTTCCCCACCGGCGCCACCATCCTCGGCCACAAGGGCATCGAACA
GGCCTACCGCACCGGCCGTGGCCTCATCACCATGCGCGCCGTGGTCAACACCGAGGAGATCAACGGCCGCATGTGCCTGG
TGGTCACCGAACTGCCGTACCAGGTCAATCCGGATCGTCTCGTCGTCTCCATCCGCGAGGCCGTGCGCGACGGCAAGATC
CAGGGCATTGCCGACATGCGCGACGAGACCTCCGGCCGCACCGGCCAGCGCCTCGTGCTGGTCCTGAAGCGCGACGCCGT
GCCGAAGGTGGTGCTGAACAACCTGTACAAGCACTCCCAGCTGCAGCAGACCTTCGGCGCCAACATGCTGGCCTTGGTCG
ACGGCGTGCCGCGCACACTGAGCCTGGACGCCTTCATCCGCCACTGGGTGAACCACCAGCTCGACGTGATCGCCCGCCGC
ACCGCGTACCTGAAGCGCGAGGCCGAGGAGCGCGACCACATCCTGCAGGGGTATCTCAAGGCCCTGGACATGCTGGACGA
GGTCATCGCCCTCATCCGCGCCTCCGAGGACACCGATACCGCCCGTACCGGCCTTATGGAGCTGCTGGACATCGACCAGG
TGCAGGCGGACGCCATCCTGGCCATGCAGCTGCGCACGCTGACCCGCATGAACCGCGACAAGATCGTGGCCGAGCATGAG
GAATTGCAGCGCAGGATCGCCGACTACATCGACATCCTCGCCAAACCGGAACGCCAGCGCAAGATCATCGGCGACGAACT
CGACGAGATCGTGGCCAAGTACGGCGACGAACGCCGCACCCGAATCCTGCCGTTCTCCGGCGAGATGAACGTCGAAGACC
TGATCGCCGAAGAGAACGTGGTGGTCACCGTGACCCACTCCGGTTTCATCAAACGCACCAAGGCCGACGAATACCGCGCC
CAGCACCGCGGCGGCAAGGGCATCAAGGGCACCAAGCTGCGCGAGGACGACGTGGTGGATCACTTCTTCCTGACCTCCAC
GCACAACTGGCTGCTGTTCTTCACCAACAAGGGGCGCGTGTACCGCATCAAAGCCTACGAGCTACCCGAAGGCTCGCGCG
ATTCCAAGGGCCAGCACGTGGCCAACCTGCTGCAGTTCGCGCCCGATGAGACCATCCAGACCGTGCTGTCCATCCCGAAC
TATGAGGTGGCCAGATATCTGGTGCTCGCCACCCGATCCGGCAAGGTCAAGAAGACCCCGCTGGCCGAGTACGATTCCCC
GCGTCAGGGCGGTCTGATCGCCGTGCGACTCATGGCCGACGAGAACGGCGAGAACGCCGACGAGCTCATCGGCGCCGCGT
TGTGCAACGCGCAGGACGACATCATCCTGGTGTCCAGGCTTGGCATGAGTCTCAAGTTCCAGGCCGACGACGAACAGCTG
CGCCCGATGGGCCGTCAGACCGCCGGTGTGCAGGGCATGAAGTTCCGTGCGGACGACAGCCTGCTGGCGATGGATGTGGT
GCCGAGCGACTCCGACAAGGACCTGTTCGTGGTGACCAACGAGGGCTTCGCCAAGCGCACCGCCATCGGCGAGTACCGTC
TGCAGGGGCGCAATGGTCTGGGCGTCAAGGCCGTGCAGCTGGTCGAAGGCCGCGGCGCGCTGGTGGGTGCGCTCGTGGTG
TCCGAAGACGATCAGGTCATGGCCATCATGAAGTCCGGCAAGGTGATCCGCTCCAATGTGGACGAGGTCAAGCGCACCGG
GCGAAACACCCAGGGCGTGACCTTCGCCAAGCCCGACAAGGGCGACATGATCCTCTCCATCGCCCGTAACGAGGAGAAGG
ACGAGCCCGAGGAAGACGGCGGTACGGCAACGAACGGAGCCGGTGAGACCGTGCAATCCGACAAGAATGTGAACAACCCG
GACGAGGCGTGA

Upstream 100 bases:

>100_bases
AACGCCAAGAACGTGCGTTGGATCGATGCGTAACGGAATCCTCCAACCTCCCTCGTCAGAGGGAGGTACACAACGGACTT
AGACAATTAAAGGAACAACA

Downstream 100 bases:

>100_bases
GCAGCGTCCCGAAAAGCTGGTAGCCTCGCATACAACAGAGGCTGCCGTCCAGCCTGGTAAGGAGAAACGATGAGCGAGAA
TCTCGAAGACAACGAGACCC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 883; Mature: 882

Protein sequence:

>883_residues
MADENNTGDEQFTPDGSMEPLSPQEADTTDYGLMESGERIQRKDLQQEMRESYLAYALSVIVERALPDVRDGMKPVHRRV
IYAMYDGGYRPDRGYNKCSRVVGDVMGKYHPHGDSAIYDTLVRMAQSWSMRNMLVDGQGNFGSPGDDPAAAMRYTECRMA
PLAMEMVRDIDKDTVDFVPNYDGKTQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNMREVADGVHWALDHPDASREEL
LENLIRIIKGPDFPTGATILGHKGIEQAYRTGRGLITMRAVVNTEEINGRMCLVVTELPYQVNPDRLVVSIREAVRDGKI
QGIADMRDETSGRTGQRLVLVLKRDAVPKVVLNNLYKHSQLQQTFGANMLALVDGVPRTLSLDAFIRHWVNHQLDVIARR
TAYLKREAEERDHILQGYLKALDMLDEVIALIRASEDTDTARTGLMELLDIDQVQADAILAMQLRTLTRMNRDKIVAEHE
ELQRRIADYIDILAKPERQRKIIGDELDEIVAKYGDERRTRILPFSGEMNVEDLIAEENVVVTVTHSGFIKRTKADEYRA
QHRGGKGIKGTKLREDDVVDHFFLTSTHNWLLFFTNKGRVYRIKAYELPEGSRDSKGQHVANLLQFAPDETIQTVLSIPN
YEVARYLVLATRSGKVKKTPLAEYDSPRQGGLIAVRLMADENGENADELIGAALCNAQDDIILVSRLGMSLKFQADDEQL
RPMGRQTAGVQGMKFRADDSLLAMDVVPSDSDKDLFVVTNEGFAKRTAIGEYRLQGRNGLGVKAVQLVEGRGALVGALVV
SEDDQVMAIMKSGKVIRSNVDEVKRTGRNTQGVTFAKPDKGDMILSIARNEEKDEPEEDGGTATNGAGETVQSDKNVNNP
DEA

Sequences:

>Translated_883_residues
MADENNTGDEQFTPDGSMEPLSPQEADTTDYGLMESGERIQRKDLQQEMRESYLAYALSVIVERALPDVRDGMKPVHRRV
IYAMYDGGYRPDRGYNKCSRVVGDVMGKYHPHGDSAIYDTLVRMAQSWSMRNMLVDGQGNFGSPGDDPAAAMRYTECRMA
PLAMEMVRDIDKDTVDFVPNYDGKTQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNMREVADGVHWALDHPDASREEL
LENLIRIIKGPDFPTGATILGHKGIEQAYRTGRGLITMRAVVNTEEINGRMCLVVTELPYQVNPDRLVVSIREAVRDGKI
QGIADMRDETSGRTGQRLVLVLKRDAVPKVVLNNLYKHSQLQQTFGANMLALVDGVPRTLSLDAFIRHWVNHQLDVIARR
TAYLKREAEERDHILQGYLKALDMLDEVIALIRASEDTDTARTGLMELLDIDQVQADAILAMQLRTLTRMNRDKIVAEHE
ELQRRIADYIDILAKPERQRKIIGDELDEIVAKYGDERRTRILPFSGEMNVEDLIAEENVVVTVTHSGFIKRTKADEYRA
QHRGGKGIKGTKLREDDVVDHFFLTSTHNWLLFFTNKGRVYRIKAYELPEGSRDSKGQHVANLLQFAPDETIQTVLSIPN
YEVARYLVLATRSGKVKKTPLAEYDSPRQGGLIAVRLMADENGENADELIGAALCNAQDDIILVSRLGMSLKFQADDEQL
RPMGRQTAGVQGMKFRADDSLLAMDVVPSDSDKDLFVVTNEGFAKRTAIGEYRLQGRNGLGVKAVQLVEGRGALVGALVV
SEDDQVMAIMKSGKVIRSNVDEVKRTGRNTQGVTFAKPDKGDMILSIARNEEKDEPEEDGGTATNGAGETVQSDKNVNNP
DEA
>Mature_882_residues
ADENNTGDEQFTPDGSMEPLSPQEADTTDYGLMESGERIQRKDLQQEMRESYLAYALSVIVERALPDVRDGMKPVHRRVI
YAMYDGGYRPDRGYNKCSRVVGDVMGKYHPHGDSAIYDTLVRMAQSWSMRNMLVDGQGNFGSPGDDPAAAMRYTECRMAP
LAMEMVRDIDKDTVDFVPNYDGKTQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNMREVADGVHWALDHPDASREELL
ENLIRIIKGPDFPTGATILGHKGIEQAYRTGRGLITMRAVVNTEEINGRMCLVVTELPYQVNPDRLVVSIREAVRDGKIQ
GIADMRDETSGRTGQRLVLVLKRDAVPKVVLNNLYKHSQLQQTFGANMLALVDGVPRTLSLDAFIRHWVNHQLDVIARRT
AYLKREAEERDHILQGYLKALDMLDEVIALIRASEDTDTARTGLMELLDIDQVQADAILAMQLRTLTRMNRDKIVAEHEE
LQRRIADYIDILAKPERQRKIIGDELDEIVAKYGDERRTRILPFSGEMNVEDLIAEENVVVTVTHSGFIKRTKADEYRAQ
HRGGKGIKGTKLREDDVVDHFFLTSTHNWLLFFTNKGRVYRIKAYELPEGSRDSKGQHVANLLQFAPDETIQTVLSIPNY
EVARYLVLATRSGKVKKTPLAEYDSPRQGGLIAVRLMADENGENADELIGAALCNAQDDIILVSRLGMSLKFQADDEQLR
PMGRQTAGVQGMKFRADDSLLAMDVVPSDSDKDLFVVTNEGFAKRTAIGEYRLQGRNGLGVKAVQLVEGRGALVGALVVS
EDDQVMAIMKSGKVIRSNVDEVKRTGRNTQGVTFAKPDKGDMILSIARNEEKDEPEEDGGTATNGAGETVQSDKNVNNPD
EA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=324, Percent_Identity=26.5432098765432, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI19913406, Length=323, Percent_Identity=25.077399380805, Blast_Score=78, Evalue=4e-14,
Organism=Escherichia coli, GI1788562, Length=862, Percent_Identity=43.1554524361949, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=33.2417582417582, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17535065, Length=170, Percent_Identity=30.5882352941176, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=166, Percent_Identity=28.9156626506024, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=192, Percent_Identity=28.6458333333333, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=167, Percent_Identity=29.940119760479, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136538, Length=327, Percent_Identity=26.9113149847095, Blast_Score=83, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98380; Mature: 98249

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADENNTGDEQFTPDGSMEPLSPQEADTTDYGLMESGERIQRKDLQQEMRESYLAYALSV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVERALPDVRDGMKPVHRRVIYAMYDGGYRPDRGYNKCSRVVGDVMGKYHPHGDSAIYDT
HHHHHCCHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LVRMAQSWSMRNMLVDGQGNFGSPGDDPAAAMRYTECRMAPLAMEMVRDIDKDTVDFVPN
HHHHHHCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
YDGKTQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNMREVADGVHWALDHPDASREEL
CCCCCCCCEECCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHCCCEEEECCCCCCHHHH
LENLIRIIKGPDFPTGATILGHKGIEQAYRTGRGLITMRAVVNTEEINGRMCLVVTELPY
HHHHHHHHCCCCCCCCCEECCCHHHHHHHHCCCCEEEEEEEECHHHCCCEEEEEEECCCC
QVNPDRLVVSIREAVRDGKIQGIADMRDETSGRTGQRLVLVLKRDAVPKVVLNNLYKHSQ
EECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LQQTFGANMLALVDGVPRTLSLDAFIRHWVNHQLDVIARRTAYLKREAEERDHILQGYLK
HHHHHCCCEEEECCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDMLDEVIALIRASEDTDTARTGLMELLDIDQVQADAILAMQLRTLTRMNRDKIVAEHE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELQRRIADYIDILAKPERQRKIIGDELDEIVAKYGDERRTRILPFSGEMNVEDLIAEENV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCE
VVTVTHSGFIKRTKADEYRAQHRGGKGIKGTKLREDDVVDHFFLTSTHNWLLFFTNKGRV
EEEEECCCCEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEECCCCEEEEEECCCEE
YRIKAYELPEGSRDSKGQHVANLLQFAPDETIQTVLSIPNYEVARYLVLATRSGKVKKTP
EEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHEEEEEEEECCCCCCCCC
LAEYDSPRQGGLIAVRLMADENGENADELIGAALCNAQDDIILVSRLGMSLKFQADDEQL
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEECCHHHH
RPMGRQTAGVQGMKFRADDSLLAMDVVPSDSDKDLFVVTNEGFAKRTAIGEYRLQGRNGL
HHCCCHHCCCCCEEEECCCCEEEEEECCCCCCCCEEEEECCCCHHHHCCCCEEECCCCCC
GVKAVQLVEGRGALVGALVVSEDDQVMAIMKSGKVIRSNVDEVKRTGRNTQGVTFAKPDK
CCEEEEEECCCCCEEEEEEECCCCCEEEEHHCCCHHHCCHHHHHHCCCCCCCEEEECCCC
GDMILSIARNEEKDEPEEDGGTATNGAGETVQSDKNVNNPDEA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADENNTGDEQFTPDGSMEPLSPQEADTTDYGLMESGERIQRKDLQQEMRESYLAYALSV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IVERALPDVRDGMKPVHRRVIYAMYDGGYRPDRGYNKCSRVVGDVMGKYHPHGDSAIYDT
HHHHHCCHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LVRMAQSWSMRNMLVDGQGNFGSPGDDPAAAMRYTECRMAPLAMEMVRDIDKDTVDFVPN
HHHHHHCCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
YDGKTQEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNMREVADGVHWALDHPDASREEL
CCCCCCCCEECCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHCCCEEEECCCCCCHHHH
LENLIRIIKGPDFPTGATILGHKGIEQAYRTGRGLITMRAVVNTEEINGRMCLVVTELPY
HHHHHHHHCCCCCCCCCEECCCHHHHHHHHCCCCEEEEEEEECHHHCCCEEEEEEECCCC
QVNPDRLVVSIREAVRDGKIQGIADMRDETSGRTGQRLVLVLKRDAVPKVVLNNLYKHSQ
EECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LQQTFGANMLALVDGVPRTLSLDAFIRHWVNHQLDVIARRTAYLKREAEERDHILQGYLK
HHHHHCCCEEEECCCCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDMLDEVIALIRASEDTDTARTGLMELLDIDQVQADAILAMQLRTLTRMNRDKIVAEHE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELQRRIADYIDILAKPERQRKIIGDELDEIVAKYGDERRTRILPFSGEMNVEDLIAEENV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCE
VVTVTHSGFIKRTKADEYRAQHRGGKGIKGTKLREDDVVDHFFLTSTHNWLLFFTNKGRV
EEEEECCCCEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEECCCCEEEEEECCCEE
YRIKAYELPEGSRDSKGQHVANLLQFAPDETIQTVLSIPNYEVARYLVLATRSGKVKKTP
EEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHEEEEEEEECCCCCCCCC
LAEYDSPRQGGLIAVRLMADENGENADELIGAALCNAQDDIILVSRLGMSLKFQADDEQL
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEECCHHHH
RPMGRQTAGVQGMKFRADDSLLAMDVVPSDSDKDLFVVTNEGFAKRTAIGEYRLQGRNGL
HHCCCHHCCCCCEEEECCCCEEEEEECCCCCCCCEEEEECCCCHHHHCCCCEEECCCCCC
GVKAVQLVEGRGALVGALVVSEDDQVMAIMKSGKVIRSNVDEVKRTGRNTQGVTFAKPDK
CCEEEEEECCCCCEEEEEEECCCCCEEEEHHCCCHHHCCHHHHHHCCCCCCCEEEECCCC
GDMILSIARNEEKDEPEEDGGTATNGAGETVQSDKNVNNPDEA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7828880; 12000953 [H]