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The map label for this gene is hppD [H]

Identifier: 213159160

GI number: 213159160

Start: 3996623

End: 3997678

Strand: Reverse

Name: hppD [H]

Synonym: AB57_3871

Alternate gene names: 213159160

Gene position: 3997678-3996623 (Counterclockwise)

Preceding gene: 213158739

Following gene: 213159155

Centisome position: 98.7

GC content: 37.88

Gene sequence:

>1056_bases
ATGGATATTTTAGAGAACCCATTAGAATTATGCGGTTTTGCATTTATTGAGTTTGTTTCAAAAGAAAATGAATTAGATCC
AATTTTTGAAACAATCGGCTTTTCAAAAGTAGCCAAGCATAAATCGAAAAAAGCGTACTTATGGCGTCAAGGAAATATCA
ATATTATCCTGAATTATCAGCCAGAATCTTATGCTTCATTCTTTTTTAATGAGCATGGTCCATCTGCTTGTGCGATGGGA
TTCAAAACTCGTGATGCAGCAAAAGCTTTTAAAAAGGCGGTTGAACTTGGTGCAGAACCAATGTACTCAAAAGTTGGGCC
AATGGAGCTTAACATTCCGGCAATTAAAGGTATTGGTGGCATGCCAATCTTCTTGGTTGACCGCGATATTTATGAAAATG
ACTTTGTTTTCTTTGATGATGCGCAGCGTAACCCTGAAGGTGCGGGCTTAAAAGAAATCGATCACTTAACGCATAACGTC
TACAAAGGACGTATGGAGTATTGGGCAAACTTCTACGAGAAGATTTTTAACTTCCAAGAAATTCGTTATTTCGACATTAA
AGGTGAATATACAGGTTTAACCTCTAAAGCATTAACTGCACCAGATGGCATGATCCGTATTCCTTTAAATGAAGACTCAG
ACAAGGGTAACGGTCAAATTGCAGAATTCTTAGCTGATTTTAATGGCGAAGGTATTCAGCATATCGCGTTTATTTGTGAT
GACTTAATTTCGACTTGGGATAAATTGAAAGGCCTTGGTCTTAAGTTTATGACACCACCGCCAAATACATATTATGAAAT
GCTTGAAGAGCGTTTACCTGAACATGGTGAACCAACTGAAGAGTTAAAACAACGCGGTATTTTATTAGACGGCAGTACTA
AAGATGGCCAGAAGAAGCTTTTATTACAAATCTTCTCTGAAAATATGATTGGGCCAGTCTTCTTCGAATTTATTCAACGT
AAAGATGACGACGGTTTCGGTGAAGGTAACTTCAAGGCATTGTTTGAATCGATTGAACGTGACCAGATTCGTCGTGGTGT
GCTCGAAGCAAAATAA

Upstream 100 bases:

>100_bases
TTCAAACATACTCCCAGCAAATGCGTATTCTATAGAGAAAGGAGCTGACCAGATCAGCATGAGAAGTAAACGGATCAGGT
AATTACCAGAGGGAAACTAG

Downstream 100 bases:

>100_bases
GTTTTGCTTTGTCTCTAATCTAAAAAAACCAAGAGCAATGCTCTTGGTTTTTTTATGCTATTGATTAGCGGCTTTTAATA
TATTGATTAATTGAATTAAT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MDILENPLELCGFAFIEFVSKENELDPIFETIGFSKVAKHKSKKAYLWRQGNINIILNYQPESYASFFFNEHGPSACAMG
FKTRDAAKAFKKAVELGAEPMYSKVGPMELNIPAIKGIGGMPIFLVDRDIYENDFVFFDDAQRNPEGAGLKEIDHLTHNV
YKGRMEYWANFYEKIFNFQEIRYFDIKGEYTGLTSKALTAPDGMIRIPLNEDSDKGNGQIAEFLADFNGEGIQHIAFICD
DLISTWDKLKGLGLKFMTPPPNTYYEMLEERLPEHGEPTEELKQRGILLDGSTKDGQKKLLLQIFSENMIGPVFFEFIQR
KDDDGFGEGNFKALFESIERDQIRRGVLEAK

Sequences:

>Translated_351_residues
MDILENPLELCGFAFIEFVSKENELDPIFETIGFSKVAKHKSKKAYLWRQGNINIILNYQPESYASFFFNEHGPSACAMG
FKTRDAAKAFKKAVELGAEPMYSKVGPMELNIPAIKGIGGMPIFLVDRDIYENDFVFFDDAQRNPEGAGLKEIDHLTHNV
YKGRMEYWANFYEKIFNFQEIRYFDIKGEYTGLTSKALTAPDGMIRIPLNEDSDKGNGQIAEFLADFNGEGIQHIAFICD
DLISTWDKLKGLGLKFMTPPPNTYYEMLEERLPEHGEPTEELKQRGILLDGSTKDGQKKLLLQIFSENMIGPVFFEFIQR
KDDDGFGEGNFKALFESIERDQIRRGVLEAK
>Mature_351_residues
MDILENPLELCGFAFIEFVSKENELDPIFETIGFSKVAKHKSKKAYLWRQGNINIILNYQPESYASFFFNEHGPSACAMG
FKTRDAAKAFKKAVELGAEPMYSKVGPMELNIPAIKGIGGMPIFLVDRDIYENDFVFFDDAQRNPEGAGLKEIDHLTHNV
YKGRMEYWANFYEKIFNFQEIRYFDIKGEYTGLTSKALTAPDGMIRIPLNEDSDKGNGQIAEFLADFNGEGIQHIAFICD
DLISTWDKLKGLGLKFMTPPPNTYYEMLEERLPEHGEPTEELKQRGILLDGSTKDGQKKLLLQIFSENMIGPVFFEFIQR
KDDDGFGEGNFKALFESIERDQIRRGVLEAK

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=302, Percent_Identity=30.1324503311258, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI285002264, Length=302, Percent_Identity=30.1324503311258, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI14249394, Length=297, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=213, Percent_Identity=36.150234741784, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550752, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=33.4448160535117, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24667510, Length=299, Percent_Identity=33.4448160535117, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40050; Mature: 40050

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILENPLELCGFAFIEFVSKENELDPIFETIGFSKVAKHKSKKAYLWRQGNINIILNYQ
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHCCCCEEEEECCCEEEEEEEC
PESYASFFFNEHGPSACAMGFKTRDAAKAFKKAVELGAEPMYSKVGPMELNIPAIKGIGG
CCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCCC
MPIFLVDRDIYENDFVFFDDAQRNPEGAGLKEIDHLTHNVYKGRMEYWANFYEKIFNFQE
CEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IRYFDIKGEYTGLTSKALTAPDGMIRIPLNEDSDKGNGQIAEFLADFNGEGIQHIAFICD
EEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
DLISTWDKLKGLGLKFMTPPPNTYYEMLEERLPEHGEPTEELKQRGILLDGSTKDGQKKL
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHHHH
LLQIFSENMIGPVFFEFIQRKDDDGFGEGNFKALFESIERDQIRRGVLEAK
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDILENPLELCGFAFIEFVSKENELDPIFETIGFSKVAKHKSKKAYLWRQGNINIILNYQ
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHCCCCEEEEECCCEEEEEEEC
PESYASFFFNEHGPSACAMGFKTRDAAKAFKKAVELGAEPMYSKVGPMELNIPAIKGIGG
CCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCCC
MPIFLVDRDIYENDFVFFDDAQRNPEGAGLKEIDHLTHNVYKGRMEYWANFYEKIFNFQE
CEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IRYFDIKGEYTGLTSKALTAPDGMIRIPLNEDSDKGNGQIAEFLADFNGEGIQHIAFICD
EEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
DLISTWDKLKGLGLKFMTPPPNTYYEMLEERLPEHGEPTEELKQRGILLDGSTKDGQKKL
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHHHH
LLQIFSENMIGPVFFEFIQRKDDDGFGEGNFKALFESIERDQIRRGVLEAK
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]