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The map label for this gene is norM [H]

Identifier: 213158739

GI number: 213158739

Start: 3998684

End: 4000027

Strand: Reverse

Name: norM [H]

Synonym: AB57_3873

Alternate gene names: 213158739

Gene position: 4000027-3998684 (Counterclockwise)

Preceding gene: 213158740

Following gene: 213159160

Centisome position: 98.75

GC content: 39.43

Gene sequence:

>1344_bases
ATGAACCAGATTTTTAAATTATTTATTCCCATGCTTTCTAGCAATTTAATTGTAGTTTTAAGTGGATTGATTGATATTGC
TTATGTAGGGCATTTTAGTAATGACCATGTTGCCGCCTTATCGGTGACCTTATCTTTATATACAGTGGTTTATGTCATTG
GAATGGGGATACTGCAAGGTGTGATGCTTAAGCTCTCGGAAGCTTATGGTTGCCATGACATACCACGTATTCGTCAAATT
TTTATTCAAGGCGTTTGGCTGATGTTATGTTCGGCATTGGTGAGTATTGCCTTGCTTTACTTGTTCCGTGATTTACCAAA
ATTATTTGGTGCATCTGAACATGTCGTTTCAACTACTAAAAACTGTATTTGGGCTTTGGTATTTATTTTACCTGCCCATT
TATTGATGCGCTTATTTACAGCTTTGTCTCAGGTCACTGAAAATGCGTATAAGGTTTTATTATCAGATAGTCTTTTCTTC
ATTCTTAAAATTATTTTGTCCTATCTTCTGATTTATGGTGTTGCTTTATTTTCAATTCCGCCACTCGGGGCGATAGGGGC
GTTGTTAGCCACTATCATTGTACGGTGGTTTATGTTGGCCGTTTATTACCTGTTTTTTCTAGAGAAAAGGTACATCTTTA
TTGAACATCCAAAACAGTCAGTTGAAGATAGCCGGCAAAGTCTGTGTATGATTTTAAAAATAGGGATACCTACTGCGATC
ATGGCGTTGATGGACGTTGTTGCATTTTGTTCAGTTGCTATTCTGATTTTGCCTTTTGGGAGTGTGGTGTCTGCAGCCTA
TCAAATTGTCGCGAGCACTGGCGGTTTCATGTTTATTTTTCCTTCATCAATTGCCTCGGCTTATAGCATTTTGGTGTCAA
GAACTATGGGTAGCGGAAACATGAAAGAAGCAGACAAAATTGCCAGACAAAGTATATGGGTCATTATGGCAGTGAGTGGC
AGTTTATCCTTGTGTTTATGGTTGGAGCGGGGCTTAATTGTCACGTTCTATTCAGATGATTTGGCTGTACAGATTTTGGC
TGCATCACTGCTCTTGATTGTCTGCATGTCTCATTTTCTCGATGGCTTAATGACGTTACTAACATCTTTGCTGCGTTGTT
GGGATGTGTCGATTTTACCTATGCTGATTTTTTTAGTCGTGGTGCTATGTTTCGGATTGGGCGGTGGTTGGTGGATGGCT
TATAAAGGGCTGCACTGGGGGAGTCACTCTATATCTGCAATGGGAATTTATGGTTTCTGGAGTATGGCGGCCATAAGCTA
TTTAGTAGCTTGTGTATTGAGTGCCTTCTGTTTTCGTTTTAGAAAGCAATTAAGAGGTTTTTGA

Upstream 100 bases:

>100_bases
GCTGAATTTAAAACTGGTATGTCTTTTGCTTCGAATTGATGCACTAAAAATAACGTGAATATCGACATAAATCGCAAAGA
AAAAAATAAGGCATTTTTTG

Downstream 100 bases:

>100_bases
TTAGGTAGATCAACAAAGAGGATGTGCTGCTAACCATTCTTCAATCTCATTTTCAGAAATCACTTCAAAACCATGGCGCT
GTAACAGTGCCGTGGTAATC

Product: MATE family drug transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MNQIFKLFIPMLSSNLIVVLSGLIDIAYVGHFSNDHVAALSVTLSLYTVVYVIGMGILQGVMLKLSEAYGCHDIPRIRQI
FIQGVWLMLCSALVSIALLYLFRDLPKLFGASEHVVSTTKNCIWALVFILPAHLLMRLFTALSQVTENAYKVLLSDSLFF
ILKIILSYLLIYGVALFSIPPLGAIGALLATIIVRWFMLAVYYLFFLEKRYIFIEHPKQSVEDSRQSLCMILKIGIPTAI
MALMDVVAFCSVAILILPFGSVVSAAYQIVASTGGFMFIFPSSIASAYSILVSRTMGSGNMKEADKIARQSIWVIMAVSG
SLSLCLWLERGLIVTFYSDDLAVQILAASLLLIVCMSHFLDGLMTLLTSLLRCWDVSILPMLIFLVVVLCFGLGGGWWMA
YKGLHWGSHSISAMGIYGFWSMAAISYLVACVLSAFCFRFRKQLRGF

Sequences:

>Translated_447_residues
MNQIFKLFIPMLSSNLIVVLSGLIDIAYVGHFSNDHVAALSVTLSLYTVVYVIGMGILQGVMLKLSEAYGCHDIPRIRQI
FIQGVWLMLCSALVSIALLYLFRDLPKLFGASEHVVSTTKNCIWALVFILPAHLLMRLFTALSQVTENAYKVLLSDSLFF
ILKIILSYLLIYGVALFSIPPLGAIGALLATIIVRWFMLAVYYLFFLEKRYIFIEHPKQSVEDSRQSLCMILKIGIPTAI
MALMDVVAFCSVAILILPFGSVVSAAYQIVASTGGFMFIFPSSIASAYSILVSRTMGSGNMKEADKIARQSIWVIMAVSG
SLSLCLWLERGLIVTFYSDDLAVQILAASLLLIVCMSHFLDGLMTLLTSLLRCWDVSILPMLIFLVVVLCFGLGGGWWMA
YKGLHWGSHSISAMGIYGFWSMAAISYLVACVLSAFCFRFRKQLRGF
>Mature_447_residues
MNQIFKLFIPMLSSNLIVVLSGLIDIAYVGHFSNDHVAALSVTLSLYTVVYVIGMGILQGVMLKLSEAYGCHDIPRIRQI
FIQGVWLMLCSALVSIALLYLFRDLPKLFGASEHVVSTTKNCIWALVFILPAHLLMRLFTALSQVTENAYKVLLSDSLFF
ILKIILSYLLIYGVALFSIPPLGAIGALLATIIVRWFMLAVYYLFFLEKRYIFIEHPKQSVEDSRQSLCMILKIGIPTAI
MALMDVVAFCSVAILILPFGSVVSAAYQIVASTGGFMFIFPSSIASAYSILVSRTMGSGNMKEADKIARQSIWVIMAVSG
SLSLCLWLERGLIVTFYSDDLAVQILAASLLLIVCMSHFLDGLMTLLTSLLRCWDVSILPMLIFLVVVLCFGLGGGWWMA
YKGLHWGSHSISAMGIYGFWSMAAISYLVACVLSAFCFRFRKQLRGF

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=450, Percent_Identity=23.1111111111111, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49555; Mature: 49555

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA