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The map label for this gene is aceE [H]

Identifier: 213159067

GI number: 213159067

Start: 3895121

End: 3897838

Strand: Reverse

Name: aceE [H]

Synonym: AB57_3777

Alternate gene names: 213159067

Gene position: 3897838-3895121 (Counterclockwise)

Preceding gene: 213159068

Following gene: 213159066

Centisome position: 96.23

GC content: 43.16

Gene sequence:

>2718_bases
ATGGCGTTTTACGGTGACTCCGACGCACAAGAAACCCAAGAATGGCAAGATGCATTCGATTCAGTTTTACAACACATGGG
AACTGAGCGAGCGGCATTCTTGTTGGAAAAACTTTACCAACAAGCAATTGCTAAGCATGTTCCAATTCAACGTCTCAATA
CACCTTACTTAAATACAATTTCTGTTGAAGAGCAACCTGCAATGCCAGGCGACCAAGATATGGAACGCCGTATTCGTGCA
TTGATTCGTTGGAATGCCTTAGCAATGGTACTTCGCGCGAATAAAACAGGTGATGATTTAGGTGGTCACTTGGCGAGCTT
CGCATCAAGTGCAACATTATATGACGTAGGTTTTAACCATTTCTTCCGCGCTAACAGTGATAACTTTGGCGGAGATATGA
TTTATTACCAAGGACACTGTGCTCCTGGTATTTATGCACGTTCATTCCTTGAAGGACGTTTAACTGAAGAACAGTTAAGT
AATTTCCGCCGTGAAGTTGGCGGTAACGGTTTACCAAGCTATCCACATCCATATTTAATGCCTGACTATTGGCAATTCCC
AACTGTATCAATGGGTCTTGGTCCAATCATGTCGATTTATCAAGCGCACATTCAAAAATATTTGATGAACCGTGGCTTGA
TCAAAGAAGAAGATCGTAAAGTTTGGGCATATCTCGGCGATGGCGAGATGGATGAGCCAGAAAGCTTAGGCGCGATCTCA
CTAGCTGGTCGTGAGAAGCTTGATAACTTAATTTGGGTAGTTAACTGTAACTTACAGCGTCTAGATGGTCCTGTACGTGG
TAACGGTAAAATTATTCAAGAACTTGAATCAATCTTCCGTGGCGCAGGCTGGCGTGTCATTAAAGTAGTATGGGGTCGTC
ATTGGGATCCATTACTAGCTAAAGACACAAGTGGCGCATTAAAAGCACGTATGGAAGAAGCTGTTGATGGCGACTATCAG
CGCTATCAGGTAAAAGGCGGCGCATATACACGCGAAAAATTCTTTGGTAAGTACCCTGAAGCTGCGGAACTTGTAAAAGA
TTTAAGCGATGAAGATATCGATAATCTTAACCGTGGTGGTCATGACCCTTACAAGGTTTTTGCTGCATATGCAGAAGCGA
TGAAGGCAAAAGGTCAACCAACAGTAATCTTGGCGAAAACCATTAAAGGTTACGGTTTATCTGAAGAAATTGAAGCGGTG
AACAAAACTCACCAAATCAAAAAGATGCAAATTGACTCTTTAAGATATGTACGTGACCGTTTCAATCTTCCATTCACAGA
TGAGCAATTAGAAGAGCTTCCATTCTATCGCCCAAGTGAAAACTCTCCAGAAATGAAATATATGAAAGCGCGTCGTGAAG
CGTTAGGTGGTTACTTACCTGCACGTCGTCGTGAGAGTGAATCTTTAGCGATTCCTGATTTATCTGTATTTGATGCAGTG
TTGAAAGGTTCGGGTGGCAAAGAGCAATCAACCACTATGGTGATGGTTCGTTTAATTGCTGCTTTACTTAAAGAAAAAGC
AATTAAAGACCGCGTAGTGCCAATCGTTCCAGATGAAGCACGTACTTTTGGTTTAGAAGGTATGTTCCGTCAGCTTGGTA
TTTATGCCGCTCATGGTCAAAAATATACACCGGAAGACCAAGAACAGTTAATGCATTACCGTGAAGCAAAAGACGGTCAC
ATGTTACAAGAAGGGATTAACGAAGCAGGTGCGATGAGTGCATGGGCTGCGTTAGCGACAAGTTATTCAACCAATAACTT
GCCAATGATTCCAATGTACATGTACTACTCAATGTTTGGTTTCCAACGTATTGGTGATATTGCATGGGCTGCGGGTGACG
CACAAGCTCAAGGTTTCTTGTTAGGTGCGACTGCGGGCCGTACAACATTGAACGGTGAAGGCTTACAGCACCAAGACGGT
CATTCTCACATCTTGGCGAACACGATTCCAAACTGCGTATCTTATGACCCATGTTTTGGTTATGAGTTGGCTGTCATCGT
GCATGACGGTTTACAACGTATGTATGTGAACCAAGAGCGTGTGTTCTATTACTTAACTGTAATGAATGAAAACTACGAGC
ATCCTGCAATGCCAGAAGGCGTTGAAGAAGGCATTAAACGTGGTATGTATTTATTCGAGAAAGATGAAAAAGCAACTGTT
CAGTTACTTGGTTCAGGTGTAATCCTTCGCGAAGTGATTAAAGCTGCGAAAATCTTACGTGATGAATACCAAATCCATTC
AAACGTTTGGAGTGTAACAAGCTTCAATGAATTGGCACGTGATGGTATGGCATGTGAAGAATACAACCGCCTACACCCAC
TTGCTGAAGAAGTTAAAGAATCTTGGGTATCTAAACAATTACGTGGTACGGAAGGTATCGTAGTTTCTGCTACCGACCAT
ATGCGTGCTTACAGTGAACAAATCCGTGCTTATCTTCCAGATGGTCGCCCATTTGTTGCATTGGGTACAGATGGTTACGG
CCGTTCAGATACACGTGCGAACTTACGTAGTTTCTTTGGTGTTGATGCTGCGCACATCGTTGTTGCTACCTTGAAAAAAT
TAGCTGACGAAGGTGAAGTAGACGCACGTTTAGTGAAAGATGCAATTTCTAACTTTGAGCTAGATACTGACCGTCCGGTT
GCATGGGCGCCGCAAGCACATCCGGAAGTTCAGCCAGTTGCCGAATACAATGAAACGCAAACAGGTGAGGGGAACTAA

Upstream 100 bases:

>100_bases
AATAATAGGCCCCCCCCACATTCACCCGTGGCAATAACTTGAAAGGGGTAAAACGTGGTAAAAATACAAAGTAGATTAGA
GAACAAGGAACAGGTGAATT

Downstream 100 bases:

>100_bases
GCATGCAAATTAAGACCCCTGATATTGGTGTAGATAAAGCAAACGTCGCTGAAATTTTAGTAAAAGTTGGCGACCGTGTT
GAAGTTGACGACAGTATCGT

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 905; Mature: 904

Protein sequence:

>905_residues
MAFYGDSDAQETQEWQDAFDSVLQHMGTERAAFLLEKLYQQAIAKHVPIQRLNTPYLNTISVEEQPAMPGDQDMERRIRA
LIRWNALAMVLRANKTGDDLGGHLASFASSATLYDVGFNHFFRANSDNFGGDMIYYQGHCAPGIYARSFLEGRLTEEQLS
NFRREVGGNGLPSYPHPYLMPDYWQFPTVSMGLGPIMSIYQAHIQKYLMNRGLIKEEDRKVWAYLGDGEMDEPESLGAIS
LAGREKLDNLIWVVNCNLQRLDGPVRGNGKIIQELESIFRGAGWRVIKVVWGRHWDPLLAKDTSGALKARMEEAVDGDYQ
RYQVKGGAYTREKFFGKYPEAAELVKDLSDEDIDNLNRGGHDPYKVFAAYAEAMKAKGQPTVILAKTIKGYGLSEEIEAV
NKTHQIKKMQIDSLRYVRDRFNLPFTDEQLEELPFYRPSENSPEMKYMKARREALGGYLPARRRESESLAIPDLSVFDAV
LKGSGGKEQSTTMVMVRLIAALLKEKAIKDRVVPIVPDEARTFGLEGMFRQLGIYAAHGQKYTPEDQEQLMHYREAKDGH
MLQEGINEAGAMSAWAALATSYSTNNLPMIPMYMYYSMFGFQRIGDIAWAAGDAQAQGFLLGATAGRTTLNGEGLQHQDG
HSHILANTIPNCVSYDPCFGYELAVIVHDGLQRMYVNQERVFYYLTVMNENYEHPAMPEGVEEGIKRGMYLFEKDEKATV
QLLGSGVILREVIKAAKILRDEYQIHSNVWSVTSFNELARDGMACEEYNRLHPLAEEVKESWVSKQLRGTEGIVVSATDH
MRAYSEQIRAYLPDGRPFVALGTDGYGRSDTRANLRSFFGVDAAHIVVATLKKLADEGEVDARLVKDAISNFELDTDRPV
AWAPQAHPEVQPVAEYNETQTGEGN

Sequences:

>Translated_905_residues
MAFYGDSDAQETQEWQDAFDSVLQHMGTERAAFLLEKLYQQAIAKHVPIQRLNTPYLNTISVEEQPAMPGDQDMERRIRA
LIRWNALAMVLRANKTGDDLGGHLASFASSATLYDVGFNHFFRANSDNFGGDMIYYQGHCAPGIYARSFLEGRLTEEQLS
NFRREVGGNGLPSYPHPYLMPDYWQFPTVSMGLGPIMSIYQAHIQKYLMNRGLIKEEDRKVWAYLGDGEMDEPESLGAIS
LAGREKLDNLIWVVNCNLQRLDGPVRGNGKIIQELESIFRGAGWRVIKVVWGRHWDPLLAKDTSGALKARMEEAVDGDYQ
RYQVKGGAYTREKFFGKYPEAAELVKDLSDEDIDNLNRGGHDPYKVFAAYAEAMKAKGQPTVILAKTIKGYGLSEEIEAV
NKTHQIKKMQIDSLRYVRDRFNLPFTDEQLEELPFYRPSENSPEMKYMKARREALGGYLPARRRESESLAIPDLSVFDAV
LKGSGGKEQSTTMVMVRLIAALLKEKAIKDRVVPIVPDEARTFGLEGMFRQLGIYAAHGQKYTPEDQEQLMHYREAKDGH
MLQEGINEAGAMSAWAALATSYSTNNLPMIPMYMYYSMFGFQRIGDIAWAAGDAQAQGFLLGATAGRTTLNGEGLQHQDG
HSHILANTIPNCVSYDPCFGYELAVIVHDGLQRMYVNQERVFYYLTVMNENYEHPAMPEGVEEGIKRGMYLFEKDEKATV
QLLGSGVILREVIKAAKILRDEYQIHSNVWSVTSFNELARDGMACEEYNRLHPLAEEVKESWVSKQLRGTEGIVVSATDH
MRAYSEQIRAYLPDGRPFVALGTDGYGRSDTRANLRSFFGVDAAHIVVATLKKLADEGEVDARLVKDAISNFELDTDRPV
AWAPQAHPEVQPVAEYNETQTGEGN
>Mature_904_residues
AFYGDSDAQETQEWQDAFDSVLQHMGTERAAFLLEKLYQQAIAKHVPIQRLNTPYLNTISVEEQPAMPGDQDMERRIRAL
IRWNALAMVLRANKTGDDLGGHLASFASSATLYDVGFNHFFRANSDNFGGDMIYYQGHCAPGIYARSFLEGRLTEEQLSN
FRREVGGNGLPSYPHPYLMPDYWQFPTVSMGLGPIMSIYQAHIQKYLMNRGLIKEEDRKVWAYLGDGEMDEPESLGAISL
AGREKLDNLIWVVNCNLQRLDGPVRGNGKIIQELESIFRGAGWRVIKVVWGRHWDPLLAKDTSGALKARMEEAVDGDYQR
YQVKGGAYTREKFFGKYPEAAELVKDLSDEDIDNLNRGGHDPYKVFAAYAEAMKAKGQPTVILAKTIKGYGLSEEIEAVN
KTHQIKKMQIDSLRYVRDRFNLPFTDEQLEELPFYRPSENSPEMKYMKARREALGGYLPARRRESESLAIPDLSVFDAVL
KGSGGKEQSTTMVMVRLIAALLKEKAIKDRVVPIVPDEARTFGLEGMFRQLGIYAAHGQKYTPEDQEQLMHYREAKDGHM
LQEGINEAGAMSAWAALATSYSTNNLPMIPMYMYYSMFGFQRIGDIAWAAGDAQAQGFLLGATAGRTTLNGEGLQHQDGH
SHILANTIPNCVSYDPCFGYELAVIVHDGLQRMYVNQERVFYYLTVMNENYEHPAMPEGVEEGIKRGMYLFEKDEKATVQ
LLGSGVILREVIKAAKILRDEYQIHSNVWSVTSFNELARDGMACEEYNRLHPLAEEVKESWVSKQLRGTEGIVVSATDHM
RAYSEQIRAYLPDGRPFVALGTDGYGRSDTRANLRSFFGVDAAHIVVATLKKLADEGEVDARLVKDAISNFELDTDRPVA
WAPQAHPEVQPVAEYNETQTGEGN

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=58.843537414966, Blast_Score=1072, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 101863; Mature: 101732

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50003 PH_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYGDSDAQETQEWQDAFDSVLQHMGTERAAFLLEKLYQQAIAKHVPIQRLNTPYLNTI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEE
SVEEQPAMPGDQDMERRIRALIRWNALAMVLRANKTGDDLGGHLASFASSATLYDVGFNH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCHH
FFRANSDNFGGDMIYYQGHCAPGIYARSFLEGRLTEEQLSNFRREVGGNGLPSYPHPYLM
HEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PDYWQFPTVSMGLGPIMSIYQAHIQKYLMNRGLIKEEDRKVWAYLGDGEMDEPESLGAIS
CCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCEEE
LAGREKLDNLIWVVNCNLQRLDGPVRGNGKIIQELESIFRGAGWRVIKVVWGRHWDPLLA
ECCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
KDTSGALKARMEEAVDGDYQRYQVKGGAYTREKFFGKYPEAAELVKDLSDEDIDNLNRGG
CCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCCHHHHCCCC
HDPYKVFAAYAEAMKAKGQPTVILAKTIKGYGLSEEIEAVNKTHQIKKMQIDSLRYVRDR
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNLPFTDEQLEELPFYRPSENSPEMKYMKARREALGGYLPARRRESESLAIPDLSVFDAV
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
LKGSGGKEQSTTMVMVRLIAALLKEKAIKDRVVPIVPDEARTFGLEGMFRQLGIYAAHGQ
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEECCC
KYTPEDQEQLMHYREAKDGHMLQEGINEAGAMSAWAALATSYSTNNLPMIPMYMYYSMFG
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
FQRIGDIAWAAGDAQAQGFLLGATAGRTTLNGEGLQHQDGHSHILANTIPNCVSYDPCFG
HHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCC
YELAVIVHDGLQRMYVNQERVFYYLTVMNENYEHPAMPEGVEEGIKRGMYLFEKDEKATV
CEEEEEEHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCCHHHH
QLLGSGVILREVIKAAKILRDEYQIHSNVWSVTSFNELARDGMACEEYNRLHPLAEEVKE
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHCHHHHHHHH
SWVSKQLRGTEGIVVSATDHMRAYSEQIRAYLPDGRPFVALGTDGYGRSDTRANLRSFFG
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHC
VDAAHIVVATLKKLADEGEVDARLVKDAISNFELDTDRPVAWAPQAHPEVQPVAEYNETQ
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHCCCCC
TGEGN
CCCCC
>Mature Secondary Structure 
AFYGDSDAQETQEWQDAFDSVLQHMGTERAAFLLEKLYQQAIAKHVPIQRLNTPYLNTI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEE
SVEEQPAMPGDQDMERRIRALIRWNALAMVLRANKTGDDLGGHLASFASSATLYDVGFNH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCHH
FFRANSDNFGGDMIYYQGHCAPGIYARSFLEGRLTEEQLSNFRREVGGNGLPSYPHPYLM
HEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PDYWQFPTVSMGLGPIMSIYQAHIQKYLMNRGLIKEEDRKVWAYLGDGEMDEPESLGAIS
CCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCEEE
LAGREKLDNLIWVVNCNLQRLDGPVRGNGKIIQELESIFRGAGWRVIKVVWGRHWDPLLA
ECCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
KDTSGALKARMEEAVDGDYQRYQVKGGAYTREKFFGKYPEAAELVKDLSDEDIDNLNRGG
CCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHHCCCCCHHHHCCCC
HDPYKVFAAYAEAMKAKGQPTVILAKTIKGYGLSEEIEAVNKTHQIKKMQIDSLRYVRDR
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNLPFTDEQLEELPFYRPSENSPEMKYMKARREALGGYLPARRRESESLAIPDLSVFDAV
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
LKGSGGKEQSTTMVMVRLIAALLKEKAIKDRVVPIVPDEARTFGLEGMFRQLGIYAAHGQ
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEECCC
KYTPEDQEQLMHYREAKDGHMLQEGINEAGAMSAWAALATSYSTNNLPMIPMYMYYSMFG
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
FQRIGDIAWAAGDAQAQGFLLGATAGRTTLNGEGLQHQDGHSHILANTIPNCVSYDPCFG
HHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCC
YELAVIVHDGLQRMYVNQERVFYYLTVMNENYEHPAMPEGVEEGIKRGMYLFEKDEKATV
CEEEEEEHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCCHHHH
QLLGSGVILREVIKAAKILRDEYQIHSNVWSVTSFNELARDGMACEEYNRLHPLAEEVKE
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHCHHHHHHHH
SWVSKQLRGTEGIVVSATDHMRAYSEQIRAYLPDGRPFVALGTDGYGRSDTRANLRSFFG
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHC
VDAAHIVVATLKKLADEGEVDARLVKDAISNFELDTDRPVAWAPQAHPEVQPVAEYNETQ
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHCCCCC
TGEGN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]