Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 213159022

GI number: 213159022

Start: 3841907

End: 3843349

Strand: Reverse

Name: gabP [H]

Synonym: AB57_3730

Alternate gene names: 213159022

Gene position: 3843349-3841907 (Counterclockwise)

Preceding gene: 213159023

Following gene: 213159020

Centisome position: 94.89

GC content: 42.27

Gene sequence:

>1443_bases
ATGGCAACTCATCAAAATGGTTCTGAAGCCAATCACTCCCAAAGTTTAAAACATGGACTTAAATCACGCCACTTAACCAT
GATCTCGATTGCAGGGGTTATTGGTGGCTCTCTCTTTGTTGGCTCAGGCAGTATTATCTACAACACCGGCCCTGTAGTTT
TTCTAACTTATGCTTTAGGTGGTCTACTCGTTTGGTTCATCATGCGTATGTTAGGCGAGATGGCCGTTTTAAATCCTGAC
AGTGGCTCTTTTTCAACTTATGCGGACCGTGCGATTGGCCGTTGGGCAGGGTTTTCAATTGGTTGGTTGTACTGGTGTAC
GCTGGCGATGCTCATGGGCTGGGAAGCTTATGTAGCAGGAAAAATTTTAAATAACTGGTTCCCGTTTATACCGATCTGGG
TTTATATGACCGTTGTCATTGTCGCACTGGTTGTTGTCAATTTACAAAACGTCAAGAACTATGGTGAATTCGAGTTCTGG
TTTGCGCTCATCAAAGTTATCGCGATTGTTGTTTTCCTTGTGATTGGTAGTTTAGCCATCATGCATTTGTGGCCTTGGGG
CAATCCGGCTGCATCTGGTATAAGTAACTTAACCTCTCAAGGCTTTATGCCAAATGGCGGTTCATCAGTGATTACAGCCT
TGCTTGGGGTGATGTTCGCCTATATTGGCGCTGAAATTGTTACCGTAGCAGCAGCAGAGTCTGCAAATCCATCTAAAGAA
ATTCGTAAGGCATCGAACTCGGTAGTTTGGCGTATTATTTTATTCTACGTTGGTTCAATGTTCGTTGCGGTATGTTTGAT
TCCTCACAACAATGAACTTTTGAAAGATTCAACTTGGGGAACCTATAGCGTGACTTTGTCTGCACTTGGTATTCCGGGCG
CGCGCCATATCGTAAACTTCGTGGTTCTAACATCGGTATGTAGTTGCTTTAACTCAGCGCTTTACACGTGTTCACGGATG
CTATTCTCGTTGTCTAAACGTGGTGATGCACCAAAAAGTTTTGGTTCTGTAAACAGTAAAAGCAGTCCTTGGGTGGGTGT
GATTGTGTCATGCTTCTTCTCTGTAATTGCGGTAATTTTAACTGCAACAGAGAGTATGAATGTTTATGACTTCTTCATGC
TAACAACAGGTGCAGCAACACTATATGTGTACCTGACCATTGCTTATTCTCAGCTTCGTATGCGTAAAAAATTAGAAGCT
GAAGGCGTGAAGATTGACTTTAAAATGTGGATGTTCCCTTACCTAACCTATGTGGTGATCTTTGCAATTATTGGTGCAAT
TCTTACCATGTTGATTGAAGGTACTTATTTTAAAGAAGTGATTTACACCACAGCATTGTTCGGCATTATTGTGTTCTTCG
GGTTATTGTCTGAAAAGCTAGGTTGGGGTAAAGACCGTCGTGCAACCCATTTAACTCATAGCCATGAAGAAAAGTTAGTT
TAA

Upstream 100 bases:

>100_bases
TTAGGAATTGGGCAGAACGGCTAAATTTTTAGGGGATATTTTTTGGCTTCGGAGGATTTCCGAGACTAGCCGATATCCTC
CATATATTAAGGAAAATGAT

Downstream 100 bases:

>100_bases
ATTTTTAAATCAAAAGAGCCTCACAGTGAGGCTCTTTTTTATTTTGCTCAGATAAAAAGATCAATTCAGTGTGGGTACAC
CTGCTTCACGTAAGCACTGG

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MATHQNGSEANHSQSLKHGLKSRHLTMISIAGVIGGSLFVGSGSIIYNTGPVVFLTYALGGLLVWFIMRMLGEMAVLNPD
SGSFSTYADRAIGRWAGFSIGWLYWCTLAMLMGWEAYVAGKILNNWFPFIPIWVYMTVVIVALVVVNLQNVKNYGEFEFW
FALIKVIAIVVFLVIGSLAIMHLWPWGNPAASGISNLTSQGFMPNGGSSVITALLGVMFAYIGAEIVTVAAAESANPSKE
IRKASNSVVWRIILFYVGSMFVAVCLIPHNNELLKDSTWGTYSVTLSALGIPGARHIVNFVVLTSVCSCFNSALYTCSRM
LFSLSKRGDAPKSFGSVNSKSSPWVGVIVSCFFSVIAVILTATESMNVYDFFMLTTGAATLYVYLTIAYSQLRMRKKLEA
EGVKIDFKMWMFPYLTYVVIFAIIGAILTMLIEGTYFKEVIYTTALFGIIVFFGLLSEKLGWGKDRRATHLTHSHEEKLV

Sequences:

>Translated_480_residues
MATHQNGSEANHSQSLKHGLKSRHLTMISIAGVIGGSLFVGSGSIIYNTGPVVFLTYALGGLLVWFIMRMLGEMAVLNPD
SGSFSTYADRAIGRWAGFSIGWLYWCTLAMLMGWEAYVAGKILNNWFPFIPIWVYMTVVIVALVVVNLQNVKNYGEFEFW
FALIKVIAIVVFLVIGSLAIMHLWPWGNPAASGISNLTSQGFMPNGGSSVITALLGVMFAYIGAEIVTVAAAESANPSKE
IRKASNSVVWRIILFYVGSMFVAVCLIPHNNELLKDSTWGTYSVTLSALGIPGARHIVNFVVLTSVCSCFNSALYTCSRM
LFSLSKRGDAPKSFGSVNSKSSPWVGVIVSCFFSVIAVILTATESMNVYDFFMLTTGAATLYVYLTIAYSQLRMRKKLEA
EGVKIDFKMWMFPYLTYVVIFAIIGAILTMLIEGTYFKEVIYTTALFGIIVFFGLLSEKLGWGKDRRATHLTHSHEEKLV
>Mature_479_residues
ATHQNGSEANHSQSLKHGLKSRHLTMISIAGVIGGSLFVGSGSIIYNTGPVVFLTYALGGLLVWFIMRMLGEMAVLNPDS
GSFSTYADRAIGRWAGFSIGWLYWCTLAMLMGWEAYVAGKILNNWFPFIPIWVYMTVVIVALVVVNLQNVKNYGEFEFWF
ALIKVIAIVVFLVIGSLAIMHLWPWGNPAASGISNLTSQGFMPNGGSSVITALLGVMFAYIGAEIVTVAAAESANPSKEI
RKASNSVVWRIILFYVGSMFVAVCLIPHNNELLKDSTWGTYSVTLSALGIPGARHIVNFVVLTSVCSCFNSALYTCSRML
FSLSKRGDAPKSFGSVNSKSSPWVGVIVSCFFSVIAVILTATESMNVYDFFMLTTGAATLYVYLTIAYSQLRMRKKLEAE
GVKIDFKMWMFPYLTYVVIFAIIGAILTMLIEGTYFKEVIYTTALFGIIVFFGLLSEKLGWGKDRRATHLTHSHEEKLV

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=444, Percent_Identity=52.027027027027, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1786302, Length=423, Percent_Identity=35.2245862884161, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI87081708, Length=417, Percent_Identity=34.052757793765, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1786789, Length=435, Percent_Identity=35.1724137931034, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI48994972, Length=472, Percent_Identity=34.3220338983051, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1790653, Length=472, Percent_Identity=32.8389830508475, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788480, Length=416, Percent_Identity=32.6923076923077, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786602, Length=399, Percent_Identity=36.5914786967419, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87081915, Length=475, Percent_Identity=31.1578947368421, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081869, Length=324, Percent_Identity=24.3827160493827, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=384, Percent_Identity=24.21875, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=438, Percent_Identity=32.4200913242009, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320772, Length=433, Percent_Identity=32.7944572748268, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=409, Percent_Identity=32.2738386308068, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=489, Percent_Identity=29.2433537832311, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=445, Percent_Identity=29.2134831460674, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=445, Percent_Identity=27.6404494382022, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=476, Percent_Identity=28.3613445378151, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=27.1186440677966, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=435, Percent_Identity=26.6666666666667, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=419, Percent_Identity=28.6396181384248, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=29.6758104738155, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=423, Percent_Identity=23.8770685579196, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=26.1083743842365, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=25.41567695962, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=438, Percent_Identity=25.5707762557078, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=453, Percent_Identity=26.9315673289183, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=498, Percent_Identity=25.1004016064257, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=513, Percent_Identity=24.7563352826511, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24668806, Length=421, Percent_Identity=22.0902612826603, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356285, Length=421, Percent_Identity=22.0902612826603, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668802, Length=421, Percent_Identity=22.0902612826603, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=20.7142857142857, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=20.7142857142857, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52837; Mature: 52706

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHQNGSEANHSQSLKHGLKSRHLTMISIAGVIGGSLFVGSGSIIYNTGPVVFLTYALG
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHH
GLLVWFIMRMLGEMAVLNPDSGSFSTYADRAIGRWAGFSIGWLYWCTLAMLMGWEAYVAG
HHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KILNNWFPFIPIWVYMTVVIVALVVVNLQNVKNYGEFEFWFALIKVIAIVVFLVIGSLAI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MHLWPWGNPAASGISNLTSQGFMPNGGSSVITALLGVMFAYIGAEIVTVAAAESANPSKE
HHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IRKASNSVVWRIILFYVGSMFVAVCLIPHNNELLKDSTWGTYSVTLSALGIPGARHIVNF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHH
VVLTSVCSCFNSALYTCSRMLFSLSKRGDAPKSFGSVNSKSSPWVGVIVSCFFSVIAVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TATESMNVYDFFMLTTGAATLYVYLTIAYSQLRMRKKLEAEGVKIDFKMWMFPYLTYVVI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
FAIIGAILTMLIEGTYFKEVIYTTALFGIIVFFGLLSEKLGWGKDRRATHLTHSHEEKLV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHCCCC
>Mature Secondary Structure 
ATHQNGSEANHSQSLKHGLKSRHLTMISIAGVIGGSLFVGSGSIIYNTGPVVFLTYALG
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHH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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]