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The map label for this gene is envZ [H]

Identifier: 213158976

GI number: 213158976

Start: 3797422

End: 3798879

Strand: Direct

Name: envZ [H]

Synonym: AB57_3678

Alternate gene names: 213158976

Gene position: 3797422-3798879 (Clockwise)

Preceding gene: 213158975

Following gene: 213158977

Centisome position: 93.75

GC content: 41.29

Gene sequence:

>1458_bases
GTGAGTTTAGAGCCAATACCACCGCAAACCTTTACCGACTACGTTGCGTACTCAGAGCGTAAACGGACCCGATGGGAACG
TTTTCTCGATAAGATTAAGCCACGTTCTGCGGCCATGCGTACCACAATTTTGGTACTGCTGGTGGTACTCTTTAGCTTAT
TTATGTCATTGTGGTTTTTTTGGCGAACCCTCTATTTACCTGAAATTCAGCAACATGCACGCTATCTAGCAGTTGAACTA
GAACTGGTAAATAACCCTAATATTCGTATTTTTCATCGCGATAGCGAAGTTGACGTCGACACATGGTTACGCAATCGGGT
TGGCATTGAATATGTCACGAACCCCAAAGAATATCCAAGTGTACGCGATAAAATTATTGCCGAGTTTTTTACCAACCAAG
TTGAGCAAAAACTGGCAAATGAAATTGGCGCAAAAGACGTTACTGTCTATTTCCAATTTAAACCTAGCCCACGTATCTGG
ATTCAAACGCCAGAAATGCATGGTAACTGGGTTCGTGAGCCTTTAAAAACCTATGCCAACTATAGCCCCGAGCTACTGGT
AGGCTGGGTTGTGGGTGTCCCATTAGTTTCGGCCATCATTATTTTAATTTTGGTTCGACAAATGAACCGACCATTACGTC
GTTTGCAAAATGCTGCCAACGAATACAGTAAGTCTGGAACTGCACCTTATTTAGATACCAACCATGGCCCTTTAGAAATT
CGCCAAGTAAACCAAGCATTTAACCGTATGGTATATACGCTTGAACAAACTGAGCGTGAAAGACGAATCATGCTAGCGGG
AATTTCACATGATTTAAGGACTCCCCTCACACGTATTCGTTTAACTGCAGAGATGCTACCTGATGAGTTTCTACGTGAAG
GTCTGGTTTATGACGTAGATGATATGGATGCGATTCTAAATCAATTCATCTCATATATGCGCGATGGTTCAGATGAGGAA
TTAAAAGACACCAATATCAATATTCTTTTGCAAGAATTGGTGGTTCAGTTTAAACCCCTTGATATTCGCTTTAACATGCA
GGATGTTCCCATTATTCCTGCACGCAGCCTCTCTTTAAAACGACTTATTGCCAACCTCATTAATAACGCAAAGCGTTATG
GTGCTGAACCAATCGAACTCAGTGCAAAGGTTGAAAATGAACATATTTTAATTACGGTTGCTGACCATGGTGAAGGCATT
CCTGAAGATCAAATAGAAGAATTAATGCAGCCTTTTGTAAGAGGCAACTCGGCTAGAACGATTCAGGGAAGCGGTTTGGG
TCTTGCCATTGTTAAACGTATTGTCGATATTCACCAAGGTGAAATCCAGATTCACAATCGTGAACAAGGCGGTTTAGAGG
TAATTATTTCTTTACCAATTCCAAAACCCGCCCCTGAAGAAAATACAACGCACAATCCTTTAGAAAAAATCAAACAAACT
TTAAGTGAGCGCTTTTAA

Upstream 100 bases:

>100_bases
TTGAAGATAACCCGGCACGTGCACGTTACATTCAAACTGTATGGGGCGTAGGCTATGTGTTTGTTCCGGATGGTGCTGAA
TAAGCTTGAGATAAAATAGA

Downstream 100 bases:

>100_bases
TTTGAGCAATTGAATATTTAAAGCGCTTATTTTAAACCTCAAAAAAGACAATAATAATCAATATATTAAAAATCATAAAA
ATAAGTTATACCCGCATTTA

Product: two-component system sensory histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSLEPIPPQTFTDYVAYSERKRTRWERFLDKIKPRSAAMRTTILVLLVVLFSLFMSLWFFWRTLYLPEIQQHARYLAVEL
ELVNNPNIRIFHRDSEVDVDTWLRNRVGIEYVTNPKEYPSVRDKIIAEFFTNQVEQKLANEIGAKDVTVYFQFKPSPRIW
IQTPEMHGNWVREPLKTYANYSPELLVGWVVGVPLVSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEI
RQVNQAFNRMVYTLEQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEE
LKDTNINILLQELVVQFKPLDIRFNMQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVENEHILITVADHGEGI
PEDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGEIQIHNREQGGLEVIISLPIPKPAPEENTTHNPLEKIKQT
LSERF

Sequences:

>Translated_485_residues
MSLEPIPPQTFTDYVAYSERKRTRWERFLDKIKPRSAAMRTTILVLLVVLFSLFMSLWFFWRTLYLPEIQQHARYLAVEL
ELVNNPNIRIFHRDSEVDVDTWLRNRVGIEYVTNPKEYPSVRDKIIAEFFTNQVEQKLANEIGAKDVTVYFQFKPSPRIW
IQTPEMHGNWVREPLKTYANYSPELLVGWVVGVPLVSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEI
RQVNQAFNRMVYTLEQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEE
LKDTNINILLQELVVQFKPLDIRFNMQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVENEHILITVADHGEGI
PEDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGEIQIHNREQGGLEVIISLPIPKPAPEENTTHNPLEKIKQT
LSERF
>Mature_484_residues
SLEPIPPQTFTDYVAYSERKRTRWERFLDKIKPRSAAMRTTILVLLVVLFSLFMSLWFFWRTLYLPEIQQHARYLAVELE
LVNNPNIRIFHRDSEVDVDTWLRNRVGIEYVTNPKEYPSVRDKIIAEFFTNQVEQKLANEIGAKDVTVYFQFKPSPRIWI
QTPEMHGNWVREPLKTYANYSPELLVGWVVGVPLVSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEIR
QVNQAFNRMVYTLEQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEEL
KDTNINILLQELVVQFKPLDIRFNMQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVENEHILITVADHGEGIP
EDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGEIQIHNREQGGLEVIISLPIPKPAPEENTTHNPLEKIKQTL
SERF

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=443, Percent_Identity=34.0857787810384, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=30.4832713754647, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=29.3478260869565, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786912, Length=259, Percent_Identity=31.2741312741313, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=26.643598615917, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=26.978417266187, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=24.5033112582781, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=26.25, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=26.3345195729537, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=27.6450511945392, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=310, Percent_Identity=24.8387096774194, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=26.7241379310345, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=254, Percent_Identity=27.1653543307087, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=284, Percent_Identity=24.2957746478873, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=24.8908296943231, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=278, Percent_Identity=24.4604316546763, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56169; Mature: 56037

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEPIPPQTFTDYVAYSERKRTRWERFLDKIKPRSAAMRTTILVLLVVLFSLFMSLWFF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WRTLYLPEIQQHARYLAVELELVNNPNIRIFHRDSEVDVDTWLRNRVGIEYVTNPKEYPS
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEEECCCCCCHHHHHHHCCCCEEECCCCCCHH
VRDKIIAEFFTNQVEQKLANEIGAKDVTVYFQFKPSPRIWIQTPEMHGNWVREPLKTYAN
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHC
YSPELLVGWVVGVPLVSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RQVNQAFNRMVYTLEQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVD
HHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHCHHHHHHHHHHHCCHHHHHCCCEECCH
DMDAILNQFISYMRDGSDEELKDTNINILLQELVVQFKPLDIRFNMQDVPIIPARSLSLK
HHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHH
RLIANLINNAKRYGAEPIELSAKVENEHILITVADHGEGIPEDQIEELMQPFVRGNSART
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCE
IQGSGLGLAIVKRIVDIHQGEIQIHNREQGGLEVIISLPIPKPAPEENTTHNPLEKIKQT
EECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHH
LSERF
HHHCC
>Mature Secondary Structure 
SLEPIPPQTFTDYVAYSERKRTRWERFLDKIKPRSAAMRTTILVLLVVLFSLFMSLWFF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WRTLYLPEIQQHARYLAVELELVNNPNIRIFHRDSEVDVDTWLRNRVGIEYVTNPKEYPS
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEEECCCCCCHHHHHHHCCCCEEECCCCCCHH
VRDKIIAEFFTNQVEQKLANEIGAKDVTVYFQFKPSPRIWIQTPEMHGNWVREPLKTYAN
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHC
YSPELLVGWVVGVPLVSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
RQVNQAFNRMVYTLEQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVD
HHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHCHHHHHHHHHHHCCHHHHHCCCEECCH
DMDAILNQFISYMRDGSDEELKDTNINILLQELVVQFKPLDIRFNMQDVPIIPARSLSLK
HHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHH
RLIANLINNAKRYGAEPIELSAKVENEHILITVADHGEGIPEDQIEELMQPFVRGNSART
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCE
IQGSGLGLAIVKRIVDIHQGEIQIHNREQGGLEVIISLPIPKPAPEENTTHNPLEKIKQT
EECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHH
LSERF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]