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The map label for this gene is gltP [H]

Identifier: 213158844

GI number: 213158844

Start: 3643265

End: 3644584

Strand: Reverse

Name: gltP [H]

Synonym: AB57_3539

Alternate gene names: 213158844

Gene position: 3644584-3643265 (Counterclockwise)

Preceding gene: 213158845

Following gene: 213158837

Centisome position: 89.98

GC content: 39.77

Gene sequence:

>1320_bases
GTGACAAAAAATTGCTCGAATGAAAAGCAAGCTCATGTCATATTTACAAAAGGATTGCCTACTGAAAAAAATAATGTTGA
TATGAACTTAAATACACAAATTCTGATTGCTGCCATTTTAGGTTTAGCCTTTGGCTTCCTACTTACCATGTATCCGGACA
CTGCTTTTGTAAAGCACAGTTTATATGGATTAGGCATATTAAGTAGTGTTTTTATTGGGCTACTTAAAATGTTGTTGGTG
CCATTAATTTTTAGCTCCATTGTGGTTGGAGTTTCAAATTTGCAGGCAGGTGGACAATTAGGCCCAGTTTGGAAAATCAC
ATTCTTGTGTTGTATCACCACCACCACCTTGGCCTTAATTTTAGGTATTAGCTGTGCTCATTTGTTTGAGGTCGGGCGAG
GTGTAGATATTTCAATTTTTCAGGCATCTATGCAAAGCTATCAAACACCAGATAGTTTAAACCCGGCAACTTTCTTCACT
AATTTTATTCAAAATACTTTAATTAACCCATTTAAAGCTTTTAGTGACGGGAATGTTTTAGCTGTCGTCGTGTTTGCTCT
ATTTGTGGGTGTTGCTTTAGTTCATGGTGGCGAACGTTTTAAAAGTATTCGGGTATTGAGTCATCAGTTTTTTGAAATGA
TGATGATGTTAGTAGGTTGGGTAATGAAATTGGCGCCGTTAGGTATTTTTGCCTTACTCGCTAAATTAATGGCTACCGAA
GACATTTCAGTATTAAGCCGATTGGCGGAGTTTGCTGCTGTGGTAACAGGTACTACTATTTTTCATGGCGCTGTTGTTTT
ACCGCTACTGCTTTGGATTTTTGGTCGTATGAGCCCTTGGACTTTCTTCAAAGGCACACGTACAGCTTTAATTACCGCAT
TTGCAACGAGCTCTAGCTCTGCCACTATGCCGCTAAGTATGAAATGCGCACAGGAAAAATTAGGTGTTCGTCCTCAAACT
GCAGGTTTTGTGATTCCATTGGGTACACAGCTCAACATGGATGGTACAGCTTTATATGAAGCTGCTGCCGCGCTCTTTGT
GGCAAATCTAGTTGGACTAGACTTAAACCTGACACAACAAATTGTAGTGTGCCTAACCGCAATGATCGCATCACTTGGAG
CACCAGGAATTCCAAGTGCGGGTATGGTTACCATGATTATGGTATTACAGTCTGTGGGTTTACCTGCCGAAGCAATTGCG
ATTTTACTTCCAATCGATCGTTTACTCGATACGGTAAGAACGGTTGTAAATGTGCAGGGAGATATGATGATTAGTGTGGT
AGTAGATCGATATACCAAAGATAAAGATATCAGTATCTAA

Upstream 100 bases:

>100_bases
ACGGTGCAAGAGGGTTTGATGCGTTTACGGGAAATTGAAACTCAATAAATAACGATGAGCCATCTGAAAAGATGGCTTTT
TTATTTTTAATTGAAACGAT

Downstream 100 bases:

>100_bases
TCTCTAAATAAAAAAGCAGGATTTATATCCTGCTTTTTTATTTTAAGCTGCTTGTAATTCAGCTCTTTTGGCTGCTGGCG
ACTGCGATAAATAACTTACC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTKNCSNEKQAHVIFTKGLPTEKNNVDMNLNTQILIAAILGLAFGFLLTMYPDTAFVKHSLYGLGILSSVFIGLLKMLLV
PLIFSSIVVGVSNLQAGGQLGPVWKITFLCCITTTTLALILGISCAHLFEVGRGVDISIFQASMQSYQTPDSLNPATFFT
NFIQNTLINPFKAFSDGNVLAVVVFALFVGVALVHGGERFKSIRVLSHQFFEMMMMLVGWVMKLAPLGIFALLAKLMATE
DISVLSRLAEFAAVVTGTTIFHGAVVLPLLLWIFGRMSPWTFFKGTRTALITAFATSSSSATMPLSMKCAQEKLGVRPQT
AGFVIPLGTQLNMDGTALYEAAAALFVANLVGLDLNLTQQIVVCLTAMIASLGAPGIPSAGMVTMIMVLQSVGLPAEAIA
ILLPIDRLLDTVRTVVNVQGDMMISVVVDRYTKDKDISI

Sequences:

>Translated_439_residues
MTKNCSNEKQAHVIFTKGLPTEKNNVDMNLNTQILIAAILGLAFGFLLTMYPDTAFVKHSLYGLGILSSVFIGLLKMLLV
PLIFSSIVVGVSNLQAGGQLGPVWKITFLCCITTTTLALILGISCAHLFEVGRGVDISIFQASMQSYQTPDSLNPATFFT
NFIQNTLINPFKAFSDGNVLAVVVFALFVGVALVHGGERFKSIRVLSHQFFEMMMMLVGWVMKLAPLGIFALLAKLMATE
DISVLSRLAEFAAVVTGTTIFHGAVVLPLLLWIFGRMSPWTFFKGTRTALITAFATSSSSATMPLSMKCAQEKLGVRPQT
AGFVIPLGTQLNMDGTALYEAAAALFVANLVGLDLNLTQQIVVCLTAMIASLGAPGIPSAGMVTMIMVLQSVGLPAEAIA
ILLPIDRLLDTVRTVVNVQGDMMISVVVDRYTKDKDISI
>Mature_438_residues
TKNCSNEKQAHVIFTKGLPTEKNNVDMNLNTQILIAAILGLAFGFLLTMYPDTAFVKHSLYGLGILSSVFIGLLKMLLVP
LIFSSIVVGVSNLQAGGQLGPVWKITFLCCITTTTLALILGISCAHLFEVGRGVDISIFQASMQSYQTPDSLNPATFFTN
FIQNTLINPFKAFSDGNVLAVVVFALFVGVALVHGGERFKSIRVLSHQFFEMMMMLVGWVMKLAPLGIFALLAKLMATED
ISVLSRLAEFAAVVTGTTIFHGAVVLPLLLWIFGRMSPWTFFKGTRTALITAFATSSSSATMPLSMKCAQEKLGVRPQTA
GFVIPLGTQLNMDGTALYEAAAALFVANLVGLDLNLTQQIVVCLTAMIASLGAPGIPSAGMVTMIMVLQSVGLPAEAIAI
LLPIDRLLDTVRTVVNVQGDMMISVVVDRYTKDKDISI

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=456, Percent_Identity=32.2368421052632, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI66773030, Length=401, Percent_Identity=34.6633416458853, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4827012, Length=472, Percent_Identity=32.8389830508475, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI40254478, Length=455, Percent_Identity=33.1868131868132, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI223468564, Length=261, Percent_Identity=39.463601532567, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223468566, Length=261, Percent_Identity=39.463601532567, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI5032093, Length=303, Percent_Identity=36.963696369637, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI21314632, Length=248, Percent_Identity=37.9032258064516, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194239697, Length=475, Percent_Identity=29.2631578947368, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI262359914, Length=376, Percent_Identity=30.0531914893617, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI301601644, Length=142, Percent_Identity=36.6197183098592, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1790514, Length=426, Percent_Identity=31.4553990610329, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1789947, Length=420, Percent_Identity=28.0952380952381, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788024, Length=419, Percent_Identity=30.0715990453461, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789473, Length=387, Percent_Identity=25.3229974160207, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=448, Percent_Identity=35.4910714285714, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=35.8851674641148, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71983106, Length=407, Percent_Identity=34.8894348894349, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71983099, Length=412, Percent_Identity=34.4660194174757, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI193206505, Length=440, Percent_Identity=32.7272727272727, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193206654, Length=440, Percent_Identity=30, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17541374, Length=412, Percent_Identity=30.5825242718447, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583025, Length=417, Percent_Identity=32.6139088729017, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17137668, Length=417, Percent_Identity=32.6139088729017, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24583023, Length=417, Percent_Identity=32.6139088729017, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI281360481, Length=418, Percent_Identity=28.2296650717703, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360483, Length=418, Percent_Identity=28.2296650717703, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17137666, Length=418, Percent_Identity=28.2296650717703, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47186; Mature: 47055

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TKNCSNEKQAHVIFTKGLPTEKNNVDMNLNTQILIAAILGLAFGFLLTMYPDTAFVKHS
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LYGLGILSSVFIGLLKMLLVPLIFSSIVVGVSNLQAGGQLGPVWKITFLCCITTTTLALI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LGISCAHLFEVGRGVDISIFQASMQSYQTPDSLNPATFFTNFIQNTLINPFKAFSDGNVL
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCHH
AVVVFALFVGVALVHGGERFKSIRVLSHQFFEMMMMLVGWVMKLAPLGIFALLAKLMATE
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DISVLSRLAEFAAVVTGTTIFHGAVVLPLLLWIFGRMSPWTFFKGTRTALITAFATSSSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHEEEEEECCCCC
ATMPLSMKCAQEKLGVRPQTAGFVIPLGTQLNMDGTALYEAAAALFVANLVGLDLNLTQQ
CCCCHHHHHHHHHHCCCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHH
IVVCLTAMIASLGAPGIPSAGMVTMIMVLQSVGLPAEAIAILLPIDRLLDTVRTVVNVQG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DMMISVVVDRYTKDKDISI
CEEHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]