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The map label for this gene is tesB [H]

Identifier: 213158845

GI number: 213158845

Start: 3644637

End: 3645509

Strand: Reverse

Name: tesB [H]

Synonym: AB57_3540

Alternate gene names: 213158845

Gene position: 3645509-3644637 (Counterclockwise)

Preceding gene: 213158847

Following gene: 213158844

Centisome position: 90.0

GC content: 43.64

Gene sequence:

>873_bases
ATGAATGCGTTAACCCAAGAACTGGTTGAGCTGCTCACTTTAGAAAAGCTTGAAGAAAATATTTACCGTGGAATCAGCCG
TAATTTGGTCGGTAAACGTGTTTTTGGAGGTCAGGTTCTTGGTCAAGCATTACGTGCTGCTTCTTACACAACTGATCGTC
CGGCGCATTCTCTGCATGCCTACTTTTTATATGGTGGTGATATTAATGCTCCAATCATCTATGAAGTAGACCGTTTGCGT
GATGGCAAAAGCTTTGTCAGCCGTCAAGTTCGGGCAATTCAGCATGGACGAGTTATTTTCTCGGCAATGGTGTCTTTTGC
TAACCCTGAAGAAGGCTTGAACTATCAGCATCCAGAACCAGATTACCCAGCTCCTGAAGCGCTAAAATCGGAAAGTGAGC
TGAAAGAAGGTATCCTGAATTTTGTACCGGAAAATGTTCGTGCAAGTTTTATGCGTGAGCGTCATGTTGAAATCCGTCCG
ATTGATCCAGTCAATCCGTTTCAACCACAACCGGAAGCGCCTTTCAATGCGCACTATATCCGTACCCATGACCGTATTCC
AAAACAGCTAGATGACATTTCATTGCATCAAGCAATTGTAGCGTTTTACTCAGACTTTACTTTGATGACAACAGCTTTAA
GACCACATGGCTTAAGTTATATTTCTCCGAGTTTGCAATGTGCCAGTATTGATCATGCGATTTATTTCCATCGCCCACTT
CGTGCTGATGAATGGATGCTCTATGACATGGAAGCTACAGTTAGTGCGGCTTCTCGCGGTTTAAACTTTGGCCGTATGTG
GCAAAATGGCCAACTCGTATGTAGTACGGTGCAAGAGGGTTTGATGCGTTTACGGGAAATTGAAACTCAATAA

Upstream 100 bases:

>100_bases
TGACTGATTGTTCCATGTACAAATAGTTTTTTATGGCACAATAGATTCTACACATCTGTCCTTTAATACCAATTTTGCCT
GCAATATGAAGGTATCTCTC

Downstream 100 bases:

>100_bases
ATAACGATGAGCCATCTGAAAAGATGGCTTTTTTATTTTTAATTGAAACGATGTGACAAAAAATTGCTCGAATGAAAAGC
AAGCTCATGTCATATTTACA

Product: acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDINAPIIYEVDRLR
DGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEPDYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRP
IDPVNPFQPQPEAPFNAHYIRTHDRIPKQLDDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPL
RADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ

Sequences:

>Translated_290_residues
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDINAPIIYEVDRLR
DGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEPDYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRP
IDPVNPFQPQPEAPFNAHYIRTHDRIPKQLDDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPL
RADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ
>Mature_290_residues
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDINAPIIYEVDRLR
DGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEPDYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRP
IDPVNPFQPQPEAPFNAHYIRTHDRIPKQLDDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPL
RADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=36.1111111111111, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=42.6470588235294, Blast_Score=238, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71988741, Length=296, Percent_Identity=34.4594594594595, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17558508, Length=308, Percent_Identity=35.3896103896104, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI115532456, Length=279, Percent_Identity=30.8243727598566, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531889, Length=279, Percent_Identity=31.5412186379928, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531885, Length=279, Percent_Identity=31.5412186379928, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI212645202, Length=290, Percent_Identity=32.4137931034483, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71982224, Length=307, Percent_Identity=29.9674267100977, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322480, Length=310, Percent_Identity=26.1290322580645, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33040; Mature: 33040

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YFLYGGDINAPIIYEVDRLRDGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEP
EEEECCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRPIDPVNPFQPQPEAPFNAHYI
CCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEE
RTHDRIPKQLDDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPL
ECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCEEEECCCC
RADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ
CCCCEEEEEHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YFLYGGDINAPIIYEVDRLRDGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEP
EEEECCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRPIDPVNPFQPQPEAPFNAHYI
CCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEE
RTHDRIPKQLDDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPL
ECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEEECCCCEEEECCCC
RADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ
CCCCEEEEEHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]