| Definition | Acinetobacter baumannii AB0057, complete genome. |
|---|---|
| Accession | NC_011586 |
| Length | 4,050,513 |
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The map label for this gene is dkgB [H]
Identifier: 213158762
GI number: 213158762
Start: 4017464
End: 4018267
Strand: Direct
Name: dkgB [H]
Synonym: AB57_3896
Alternate gene names: 213158762
Gene position: 4017464-4018267 (Clockwise)
Preceding gene: 213158761
Following gene: 213158763
Centisome position: 99.18
GC content: 40.42
Gene sequence:
>804_bases ATGAATATCCCACGTTTTGGTCTAGGAACTTTCCGCCTTAAAGAACAAGCTGTGATTGAATCTGTTAAAAATGCGCTAGA TGTCGGTTATCGTGCAATTGATACTGCTCAAATTTATGAAAATGAAGCGGCAATTGGACAAGCGATTGCTGAAAGTGGTG TATCACGTCAGGACTTATTTTTAACTACAAAAATTTGGGTAGATAACTTTGCTCAAGAGAAGTTTATTCCAAGCTTAAAA GAGAGCTTACAAAAGCTTCGTACTGACCATGTCGATTTAACTTTGATTCACTGGCCAGCACCGGATTTAGGCGTTTCAAT TCCTGAAATCATGCAGCTTTTACTTGAAGCAAAACAACAAGGCTTAACCAAACAAATTGGTATTTCAAACTTCAATATTG CACTTACCCAACAAGCAATTGACACAATTGGTGTAGAGCATATTGCAACGAACCAGATTGAGCTGAGTCCTTATCTTCAA AACCATAAACTTGTGAATTTCTTACAAGAGAAGAATATTGATGTCACTTCATACATGACGCTTGCATACGGCAAAGTGCT TCAAGATCCTGTTTTAGCGGAGATTGCAGCAGCCCATAAAGCAACGACAGCGCAAATTGCATTGGCATGGGCATTGCAGC GTGGTTTTGCAGTCATTCCATCTTCGACTAAACGTGAAAACCTGATTAGCAATTTAAAAGCACAGGATATCGAGTTAACT GCGGCTGAAATGCAAATGATTGCCGAACTCGACCGTAACAGTCGTGAAGTTAGCCCAGAGCCATGGGCACCAGTTTGGGA CTAA
Upstream 100 bases:
>100_bases AAACATCAAAGATATTTTGCTTATTCATCTATTTTTTCGCAACAATAAAAAAAGCAAAATGCACCTCAAGTTAAACAATT ATTTAATTTCAGGTGAATAC
Downstream 100 bases:
>100_bases ACTCATGAACACTCAATCAAATACGGCGTTCTCGTTATTGGCATTGGCAATAGGTGCCTTTGCCATTGGCACCACGGAAT TTTCTCCAATGGGGTTACTT
Product: 2,5-diketo-D-gluconate reductase B
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 267; Mature: 267
Protein sequence:
>267_residues MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT AAEMQMIAELDRNSREVSPEPWAPVWD
Sequences:
>Translated_267_residues MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT AAEMQMIAELDRNSREVSPEPWAPVWD >Mature_267_residues MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT AAEMQMIAELDRNSREVSPEPWAPVWD
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=34.5454545454545, Blast_Score=167, Evalue=9e-42, Organism=Homo sapiens, GI310109920, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI45446745, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI4503285, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI5453543, Length=293, Percent_Identity=33.4470989761092, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=32.3024054982818, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=33.5640138408304, Blast_Score=157, Evalue=7e-39, Organism=Homo sapiens, GI24497583, Length=287, Percent_Identity=33.7979094076655, Blast_Score=154, Evalue=1e-37, Organism=Homo sapiens, GI93277124, Length=299, Percent_Identity=31.438127090301, Blast_Score=152, Evalue=4e-37, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=34.1296928327645, Blast_Score=149, Evalue=2e-36, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=33.6996336996337, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI4502049, Length=285, Percent_Identity=35.4385964912281, Blast_Score=147, Evalue=7e-36, Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=31.6151202749141, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=31.6151202749141, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI300116273, Length=269, Percent_Identity=32.3420074349442, Blast_Score=135, Evalue=5e-32, Organism=Homo sapiens, GI300116271, Length=275, Percent_Identity=31.6363636363636, Blast_Score=124, Evalue=9e-29, Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=34.1935483870968, Blast_Score=98, Evalue=8e-21, Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=37.1681415929204, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=37.1681415929204, Blast_Score=82, Evalue=4e-16, Organism=Escherichia coli, GI1786400, Length=267, Percent_Identity=66.2921348314607, Blast_Score=366, Evalue=1e-102, Organism=Escherichia coli, GI87082198, Length=261, Percent_Identity=36.7816091954023, Blast_Score=173, Evalue=1e-44, Organism=Escherichia coli, GI1788081, Length=263, Percent_Identity=28.1368821292776, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI48994888, Length=272, Percent_Identity=27.2058823529412, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI1787674, Length=285, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=31.8840579710145, Blast_Score=155, Evalue=2e-38, Organism=Caenorhabditis elegans, GI17550248, Length=285, Percent_Identity=33.6842105263158, Blast_Score=148, Evalue=3e-36, Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=34.2465753424658, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI71998625, Length=266, Percent_Identity=32.7067669172932, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17552492, Length=266, Percent_Identity=30.8270676691729, Blast_Score=135, Evalue=3e-32, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=34.0277777777778, Blast_Score=135, Evalue=3e-32, Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=31.25, Blast_Score=123, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17564128, Length=290, Percent_Identity=28.2758620689655, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17562292, Length=269, Percent_Identity=31.5985130111524, Blast_Score=118, Evalue=4e-27, Organism=Caenorhabditis elegans, GI17561300, Length=275, Percent_Identity=28.7272727272727, Blast_Score=117, Evalue=5e-27, Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=28.2608695652174, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=27.2108843537415, Blast_Score=114, Evalue=4e-26, Organism=Saccharomyces cerevisiae, GI6324694, Length=294, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=7e-39, Organism=Saccharomyces cerevisiae, GI6320576, Length=262, Percent_Identity=35.1145038167939, Blast_Score=147, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6321896, Length=310, Percent_Identity=30.6451612903226, Blast_Score=137, Evalue=2e-33, Organism=Saccharomyces cerevisiae, GI6322556, Length=259, Percent_Identity=26.6409266409266, Blast_Score=121, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6319625, Length=287, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=1e-21, Organism=Saccharomyces cerevisiae, GI6320079, Length=248, Percent_Identity=30.241935483871, Blast_Score=91, Evalue=2e-19, Organism=Drosophila melanogaster, GI24662789, Length=288, Percent_Identity=31.5972222222222, Blast_Score=148, Evalue=4e-36, Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=32.8813559322034, Blast_Score=143, Evalue=1e-34, Organism=Drosophila melanogaster, GI221378297, Length=312, Percent_Identity=31.7307692307692, Blast_Score=134, Evalue=5e-32, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=31.9298245614035, Blast_Score=132, Evalue=2e-31, Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=35.7388316151203, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI24662781, Length=291, Percent_Identity=35.0515463917526, Blast_Score=127, Evalue=9e-30, Organism=Drosophila melanogaster, GI20129731, Length=280, Percent_Identity=30, Blast_Score=122, Evalue=3e-28, Organism=Drosophila melanogaster, GI24657054, Length=287, Percent_Identity=29.616724738676, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI21356425, Length=283, Percent_Identity=28.2685512367491, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI45553081, Length=283, Percent_Identity=29.6819787985866, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=28.6821705426357, Blast_Score=94, Evalue=7e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 29742; Mature: 29742
Theoretical pI: Translated: 4.86; Mature: 4.86
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLF CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE LTTKIWVDNFAQEKFIPSLKESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQ EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC GLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQNHKLVNFLQEKNIDVTSYMT CCHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHH LAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCHHHH AAEMQMIAELDRNSREVSPEPWAPVWD HHHHHHHHHHHCCCCCCCCCCCCCCCC >Mature Secondary Structure MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLF CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE LTTKIWVDNFAQEKFIPSLKESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQ EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC GLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQNHKLVNFLQEKNIDVTSYMT CCHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHH LAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCHHHH AAEMQMIAELDRNSREVSPEPWAPVWD HHHHHHHHHHHCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796; 11108008 [H]