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The map label for this gene is mutY [H]

Identifier: 213158753

GI number: 213158753

Start: 4011034

End: 4012068

Strand: Direct

Name: mutY [H]

Synonym: AB57_3887

Alternate gene names: 213158753

Gene position: 4011034-4012068 (Clockwise)

Preceding gene: 213158752

Following gene: 213158754

Centisome position: 99.03

GC content: 42.61

Gene sequence:

>1035_bases
ATGCCTGAATTTTCTTTTTCTGATGCCCTCTTAAACTGGTTCGATCAACATGGTCGACATGATTTGCCTTGGCAAGTCGC
AGATGATCCATATAAAGTCTGGGTTTCTGAAATTATGTTACAGCAAACTCAGGTAAAAACAGTTCTGCAATATTTTGACC
GCTTTATGGAGCGCTTCCCAACAGTAGAAGCTTTAGGCCATGCAACTTGGGATGAAGTAGCTCCTTATTGGGCAGGTCTT
GGCTATTACGCTCGTGCCCGCAATTTGCATAAAGCTGCCAGCCTTGTAGCACAACAAGGCAAATTTCCTGAAACCCTAGA
AGAATGGATTGCACTACCCGGCATTGGTCGCTCGACCGCAGGTGCACTCATGTCTTTGGGTTTACGTCAGTATGGCGTGA
TTATGGATGGCAACGTGAAACGTGTCTTAGCCCGTTTCTTTGCTATTGAAGATGACTTAAGCAAGCCACAACACGAACGT
GAAATGTGGAAACTAGCTGAAGAACTTTGCCCTACTCATCGTAATCATGACTACACTCAAGCGATTATGGACTTGGGTGC
AACCATCTGTACGCCTAAAAAGCCTCTTTGTTTATATTGTCCAATGCAAGCTCACTGTCAGGCTTATCAGCAAGGTTTAG
AACAAGAATTACCTTTTAAAAAACCGAAAAAAACACCACCTGTTAAAACGGCAGATGTTCTTATTATTCAGTGCGAAGAT
GAATGGTTCTGGCAGCAACGCCAAGCTCATGGTCTATGGGGCGGTTTATTTTGTTTACCTATTTTAGAAAATGAACATGA
ACGCTTGAAATTAAGTCAGCAATTTAAGCTACAACCTCGACCACAAACTTTTCAGATCAGTCATAGCTTTACTCACTTCA
CATGGTTACTTAATGCTCATGTGTTCCACGTGGAACCTGATCAAAAAGAACATCTGGCGATTGAACTTGAAGGCCAATGG
TTAAGCCCAGAACAAGCTATTGCTAAAGGTGTCCCAACTGCTATGAAAAAATTGATCTCGACAAGCCGTTCATGA

Upstream 100 bases:

>100_bases
GGCCCTGTTTTCATATGTCCATTTTCTTCGTTTGCTTTAAACAAAATTTCACCTAAATTTCAGCTATAATTTAGCCCTTA
CTTTTCTTCTATAGCTGTTC

Downstream 100 bases:

>100_bases
CATAGTGAGCAAAATAATTTTGATATGGCTGTGACAGGGAGTATTTTGTGCGACGTTTTGTTTCCCATCTCTCACTTGGT
TTTCTCATTATTCTATTGGC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFPTVEALGHATWDEVAPYWAGL
GYYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTAGALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHER
EMWKLAEELCPTHRNHDYTQAIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCED
EWFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAHVFHVEPDQKEHLAIELEGQW
LSPEQAIAKGVPTAMKKLISTSRS

Sequences:

>Translated_344_residues
MPEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFPTVEALGHATWDEVAPYWAGL
GYYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTAGALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHER
EMWKLAEELCPTHRNHDYTQAIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCED
EWFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAHVFHVEPDQKEHLAIELEGQW
LSPEQAIAKGVPTAMKKLISTSRS
>Mature_343_residues
PEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFPTVEALGHATWDEVAPYWAGLG
YYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTAGALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHERE
MWKLAEELCPTHRNHDYTQAIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCEDE
WFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAHVFHVEPDQKEHLAIELEGQWL
SPEQAIAKGVPTAMKKLISTSRS

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=402, Percent_Identity=33.3333333333333, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI6912520, Length=402, Percent_Identity=33.3333333333333, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298650, Length=402, Percent_Identity=33.3333333333333, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298648, Length=402, Percent_Identity=33.3333333333333, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298654, Length=402, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI115298652, Length=402, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1789331, Length=292, Percent_Identity=51.7123287671233, Blast_Score=286, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39765; Mature: 39634

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFP
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEALGHATWDEVAPYWAGLGYYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTA
CHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHH
GALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHEREMWKLAEELCPTHRNHDYTQ
HHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHH
AIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCED
HHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
EWFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAH
HHHHHHHHHCCCHHHHHEEHHHCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEECCE
VFHVEPDQKEHLAIELEGQWLSPEQAIAKGVPTAMKKLISTSRS
EEEECCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
PEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFP
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEALGHATWDEVAPYWAGLGYYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTA
CHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHH
GALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHEREMWKLAEELCPTHRNHDYTQ
HHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHH
AIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCED
HHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
EWFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAH
HHHHHHHHHCCCHHHHHEEHHHCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEECCE
VFHVEPDQKEHLAIELEGQWLSPEQAIAKGVPTAMKKLISTSRS
EEEECCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]